| ___ Falls, Nile dam site in Uganda | 34 |
| ___ Faire (re-enactors' event, informally) | 46 |
| ___ fainéant (do-nothing king) | 33 |
| ___ Fail, Ireland's coronation stone | 40 |
| ___ Fail (Irish coronation stone) | 33 |
| ___ Eye, former name of St. Paul, Minn. | 39 |
| ___ Express (Northeast corridor travel option) | 46 |
| ___ example (acted as a role model) | 35 |
| ___ exam (test given twice a year) | 34 |
| ___ ex machina (dramatic device) | 32 |
| ___ Everett Koop (former surgeon general) | 41 |
| ___ et ubique (here and everywhere) | 35 |
| ___ et rege (from God and the king) | 35 |
| ___ et quarante (Monte Carlo game) | 34 |
| ___ et labor (pray and work: Lat.) | 34 |
| ___ Esurance (cartoon spy in TV ads) | 36 |
| ___ escolar (school age, in Sonora) | 35 |
| ___ es Salaam (Tanzania's largest city) | 43 |
| ___ equivalent (measure of explosive strength) | 46 |
| ___ equivalent (measure of explosive energy) | 44 |
| ___ Eq (math major's class, for short) | 42 |
| ___ Epstein, Red Sox G.M. starting in 2002 | 42 |
| ___ English 800 (Miller malt liquor) | 36 |
| ___ English "800" (malt liquor brand) | 47 |
| ___ Engineer (M.I.T. online reference service) | 46 |
| ___ Energy (big natural gas utility) | 36 |
| ___ enemy (one who may blow up bridges) | 39 |
| ___ End (westernmost point of England) | 38 |
| ___ en place (putting in place: Fr.) | 36 |
| ___ en place (professional kitchen setup) | 41 |
| ___ en pis (from bad to worse): Fr. | 35 |
| ___ Empire, conquered by Cortés | 34 |
| ___ emma (before noon, to British signalmen) | 44 |
| ___ emma (before noon in England) | 33 |
| ___ Emblem (2002 Kentucky Derby winner) | 39 |
| ___ embarrassment (be mortified) | 32 |
| ___ Elvsted (“Hedda Gabler” character) | 46 |
| ___ Eloquent (J. Q. Adams sobriquet) | 36 |
| ___ elephant (part of a tot's lesson) | 41 |
| ___ elephant (alphabet book page) | 33 |
| ___ element (doing what you enjoy) | 34 |
| ___ eleison ("Lord, have mercy") | 42 |
| ___ el Beida (Casablanca, to its natives) | 41 |
| ___ el Amarna, Egyptian excavation site | 39 |
| ___ Eisley (cantina site on Tatooine) | 37 |
| ___ Eightball (Emily Flake comic) | 33 |
| ___ eggs (jewelry made for the Romanovs) | 40 |
| ___ Egg, "Gatsby" locale | 34 |
| ___ effort (award for trying hard) | 34 |
| ___ effect (atmospheric heating phenomenon) | 43 |
| ___ effect (1883 physics discovery) | 35 |
| ___ education (college and beyond) | 34 |
| ___ ecclesiasticae (church matters) | 35 |
| ___ ease (relieve one's mind) | 33 |
| ___ E. Tee (1992 Kentucky Derby winner) | 39 |
| ___ e sempre (now and always): It. | 34 |
| ___ Duke, a.k.a. Hunter S. Thompson | 35 |
| ___ duck (losing politician serving out a term) | 47 |
| ___ du Nord, busy depot in Paris | 32 |
| ___ du jour (restaurant's daily dish) | 41 |
| ___ du jour (restaurant special) | 32 |
| ___ du jour (French restaurant feature) | 39 |
| ___ du Diable (French penal colony) | 35 |
| ___ du Diable (former penal colony) | 35 |
| ___ Drusilla (mother of Tiberius) | 33 |
| ___ drive (engine in "Star Wars") | 43 |
| ___ Drink (Pepsi's original name) | 37 |
| ___ dragon (world's largest lizard) | 39 |
| ___ dragon (largest living lizard) | 34 |
| ___ Drago, "Rocky IV" villain | 39 |
| ___ Dove (the constellation Columba) | 36 |
| ___ Dove (constellation near Canis Major) | 41 |
| ___ Dotzauer, German skiing star | 32 |
| ___ Dorney, locale of 2012 Olympic rowing | 41 |
| ___ Doria, ship that sunk in 1956 | 33 |
| ___ Dome, old home of the Indianapolis Colts | 44 |
| ___ Dome (Orix Buffaloes' home field) | 41 |
| ___ Dome (former home of the Indianapolis Colts) | 48 |
| ___ Dome (Colts' longtime home) | 35 |
| ___ Domani Fashion Foundation Award | 35 |
| ___ Dolorosa (Christ's path to the cross) | 45 |
| ___ Doggie (Doggie Daddy's cartoon kid) | 43 |
| ___ dog (backwoods hunting pooch) | 33 |
| ___ doble (fast-paced ballroom dance) | 37 |
| ___ doble (ballroom dancing step) | 33 |
| ___ dixit (assertion without proof) | 35 |
| ___ Diurna (daily Roman notices) | 32 |
| ___ dish (bacteriologistÂ’s need) | 36 |
| ___ disco (European dance music) | 32 |
| ___ directed (medication warning) | 33 |
| ___ dire (jury selection process) | 33 |
| ___ Dinh Diem (first president of South Vietnam) | 48 |
| ___ Dingbats (pictographic computer font) | 41 |
| ___ Diner ("Alice" locale) | 36 |
| ___ dimittis (permission to leave) | 34 |
| ___ Dimittis (Christian canticle) | 33 |
| ___ Dimas, California (Bill and Ted's city) | 47 |
| ___ Digital Shorts (late-night comic bits) | 42 |
| ___ Diggory, rival of Harry Potter | 34 |
| ___ Digga (MC with "Dirty Harriet") | 45 |