| First-class flight amenity | 26 |
| First-century Roman leader | 26 |
| First-century Roman emperor | 27 |
| First-century Roman despot | 26 |
| First-century coup victim | 25 |
| First-born of siblings | 22 |
| First-anniversary gift | 22 |
| First-aid paraphernalia | 23 |
| First-aid kits of a sort | 24 |
| First-aid experts, briefly | 26 |
| First-aid expert, briefly | 25 |
| First-aid course: Abbr. | 23 |
| First-aid contrivances | 22 |
| First-aid bracer in SE Asia? | 28 |
| First-aid applications | 22 |
| First, third, or reverse | 24 |
| First, second, third, or home | 29 |
| First, second, third or home | 28 |
| First, second, third and home | 29 |
| First, second, reverse, etc. | 28 |
| First, second, or third, e.g. | 29 |
| First, second, or third | 23 |
| First, Second or Third: Abbr. | 29 |
| First, second or third, e.g. | 28 |
| First, second or third | 22 |
| First, second or reverse | 24 |
| First, second and third | 23 |
| First, second and reverse | 25 |
| FIRST ___: 264-41 B.C. | 22 |
| First ___ (ship officer) | 24 |
| First ___ (prison newcomers) | 28 |
| First ___ (all in all) | 22 |
| First ___ (above all else) | 26 |
| First year med. school class | 28 |
| First wrong guess in hangman | 28 |
| First words on many a stone | 27 |
| First words of the poem | 23 |
| First words of a reprimand | 26 |
| First words in Genesis | 22 |
| First words from a dictator? | 28 |
| First words for Hamlet | 22 |
| First word on many spines | 25 |
| First word on a sash, often | 27 |
| First word of Xmas poem | 23 |
| First word of two MLB teams | 27 |
| First word of the Mass. motto | 29 |
| First word of the Aeneid | 24 |
| First word of some sequels | 26 |
| First word of N. C. motto | 25 |
| First word of motto of N.H. | 27 |
| First word of Moore poem | 24 |
| First word of MGM's motto | 29 |
| First word of Mass. motto | 25 |
| First word of many titles | 25 |
| First word of many epitaphs | 27 |
| First word of many a title | 26 |
| First word of many a script | 27 |
| First word of many a letter | 27 |
| First word of fairy tale | 24 |
| First word of Declaration | 25 |
| First word of an Austen title | 29 |
| First word of a seasonal poem | 29 |
| First word of a quotation | 25 |
| First word of a popular hymn | 28 |
| First word of a Pacino film | 27 |
| First word of a Mozart title | 28 |
| First word of a limerick | 24 |
| First word of a letter | 22 |
| First word of a Latin epic | 26 |
| First word of a French motto | 28 |
| First word of a fairy tale | 26 |
| First word of a celebration | 27 |
| First word of a Carroll work | 28 |
| First word of The Raven | 26 |
| First word in Vergil work | 25 |
| First word in Mass. motto | 25 |
| First word in many signs | 24 |
| First word in many recipes | 26 |
| First word in many letters | 26 |
| First word in many addresses | 28 |
| First word in crosswords? | 25 |
| First word in an Austen title | 29 |
| First word in a Mozart title | 28 |
| First word in a Hugo title | 26 |
| First word in a fairy tale | 26 |
| First word in a Dickens title | 29 |
| First word for a baby, maybe | 28 |
| First women's champ: 1946 | 29 |
| First woman, in Greek myth | 26 |
| First woman to govern a state | 29 |
| First woman M.P. of England | 27 |
| First woman in Parliament | 25 |
| First woman elected governor | 28 |
| First woman attorney general | 28 |
| First Wives Club star | 24 |
| First with headlight wipers | 27 |
| First wireless telegrapher | 26 |
| First wife of Woodrow Wilson | 28 |
| First wife of Julius Caesar | 27 |
| First White House occupant | 26 |