| Subject of fission | 18 |
| Subject of Filippino Lippi's "Allegory of Music" | 62 |
| Subject of famous dissertation | 30 |
| Subject of Falco's biggest hit | 34 |
| Subject of Exodus 20:10 | 23 |
| Subject of evolutionary study | 29 |
| Subject of escape literature | 28 |
| Subject of equitation | 21 |
| Subject of environmentalist study | 33 |
| Subject of Emir Khalifa bin Hamad | 33 |
| Subject of Elizabeth, briefly | 29 |
| Subject of Elizabeth | 20 |
| Subject of Edward Hopper's "Nighthawks" | 53 |
| Subject of Edmond Rostand's play "L'Aiglon" | 61 |
| Subject of E.P.A. monitoring | 28 |
| Subject of Drumnadrochit village observation | 44 |
| Subject of dozens of Degas paintings | 36 |
| Subject of discussion | 21 |
| Subject of discourse | 20 |
| Subject of diabolism | 20 |
| Subject of debate | 17 |
| Subject of Dante's "Inferno" | 42 |
| Subject of Cyrus the Great | 26 |
| Subject of current thinking? | 28 |
| Subject of corroboration | 24 |
| Subject of Copland's "Portrait" | 45 |
| Subject of conversation | 23 |
| Subject of contemplation? | 25 |
| Subject of conspiracy rumors for nearly 50 years | 48 |
| Subject of confession | 21 |
| Subject of comparison for a teenager's bedroom | 50 |
| Subject of Colonial American ire | 32 |
| Subject of Coleridge Rime | 25 |
| Subject of close-up photos since 1965 | 37 |
| Subject of certain count down | 29 |
| Subject of Caesar's writing | 31 |
| Subject of Caesar | 17 |
| Subject of Broadway's "Jersey Boys" | 49 |
| Subject of Boyle's law | 26 |
| Subject of Bohr's theory | 28 |
| Subject of Bohr's research | 30 |
| Subject of Blake poem | 21 |
| Subject of biotech study | 24 |
| Subject of bioinformatics | 25 |
| Subject of big 1970s headlines | 30 |
| Subject of bargaining | 21 |
| Subject of B.F.'s kite experiment | 37 |
| Subject of “The Motorcycle Diaries” | 43 |
| Subject of Avogadro's law | 29 |
| Subject of Attila | 17 |
| Subject of Atahualpa | 20 |
| Subject of assessment | 21 |
| Subject of Asimov's three laws | 34 |
| Subject of Article III, Section 3 of the Constitution | 53 |
| Subject of Article III Section 3 of the Constitution | 52 |
| Subject of Article I, Section 8 of the Constitution | 51 |
| Subject of Article I, Section 3, of the Constitution | 52 |
| Subject of anxiety? | 19 |
| Subject of an urban legend about tantric sex | 44 |
| Subject of an S.E.C. inquiry | 28 |
| Subject of an Ogden Nash ode | 28 |
| Subject of an ode | 17 |
| Subject of an insurance investigation | 37 |
| Subject of an insurance appraisal | 33 |
| Subject of an H.G. Wells novel | 30 |
| Subject of an FDR sound bite | 28 |
| Subject of an FDA dietary-supplement ban | 40 |
| Subject of an FAA investigation | 31 |
| Subject of an exhaustive E.P.A. study? | 38 |
| Subject of an essay | 19 |
| Subject of an encoded message, maybe | 36 |
| Subject of an Emil Ludwig biography | 35 |
| Subject of an Elton John song | 29 |
| Subject of an Easter song | 25 |
| Subject of an E.E. Cummings "portrait" | 48 |
| Subject of an awkward meeting, perhaps | 38 |
| Subject of an assay test | 24 |
| Subject of an art museum in The Hague | 37 |
| Subject of an art museum in St. Petersburg, Florida | 51 |
| Subject of an antique auto owner's quest | 44 |
| Subject of an Anouilh play | 26 |
| Subject of an anonymous call, maybe | 35 |
| Subject of an annual presidential speech | 40 |
| Subject of an annual Ottawa festival | 36 |
| Subject of an annual March 14 celebration and of this puzzle, celebrated in both a literal and a numerical way in the first square of the starred answers, reading left to right | 177 |
| Subject of an annual festival in Holland, Mich. | 47 |
| Subject of an annual contest held in Brooklyn | 45 |
| Subject of an annual Colorado brewing festival | 46 |
| Subject of an Andrew Wyeth portrait series | 42 |
| Subject of an alert | 19 |
| Subject of an Alanis Morissette tune | 36 |
| Subject of an air traveler's complaint | 42 |
| Subject of an adoptee's quest, maybe | 40 |
| Subject of an 1898 slogan | 25 |
| Subject of an 1867 sale | 23 |
| Subject of an 1866 Manet painting | 33 |
| Subject of an 1857 Supreme Court decision | 41 |
| Subject of an 11/26/22 discovery | 32 |
| Subject of Amendment XVII | 25 |
| Subject of adoration | 20 |