| Four times a day, in an Rx | 26 |
| Four time AL batting champ | 26 |
| Four thirds, for example | 24 |
| Four song releases, typically | 29 |
| Four Seasons number, e.g. | 25 |
| Four seasons in Sonora | 22 |
| Four seasons in Seville | 23 |
| Four seasons in Madrid | 22 |
| Four Seasons Hotel architect | 28 |
| Four scoreless quarters | 23 |
| Four rows at the Palace | 23 |
| Four quarters, to a Jet | 23 |
| Four quarters, in Quito | 23 |
| Four quarters, in France | 24 |
| Four quarters' equivalent | 29 |
| Four on the ground, maybe | 25 |
| Four on some old faces | 22 |
| Four of ___ (high poker hand) | 29 |
| Four o'clock, to some | 25 |
| Four o'clock swizzler | 25 |
| Four o'clock serving | 24 |
| Four o'clock services | 25 |
| Four o'clock service? | 25 |
| Four o'clock drink | 22 |
| Four o'clock dainty | 23 |
| Four o'clock china | 22 |
| Four o'clock (abbr.) | 24 |
| Four Noble Truths formulator | 28 |
| Four New Testament books | 24 |
| Four Monopoly properties | 24 |
| Four Monopoly assets: Abbr. | 27 |
| Four laps on a track, e.g. | 26 |
| Four is superior to it | 22 |
| Four inches, to an equestrian | 29 |
| Four inches, to a horseman | 26 |
| Four in a Motown group | 22 |
| Four hours before noon | 22 |
| Four Holy Roman emperors | 24 |
| Four H.R.E. sovereigns | 22 |
| Four Corners-area tribe | 23 |
| Four Corners-area Indians | 25 |
| Four Corners-area Indian | 24 |
| Four commands to a dog | 22 |
| Four bells, aboard ship | 23 |
| Four beats in 4/4 time | 22 |
| Four balls to a Torontonian | 27 |
| Four and a score or more | 24 |
| Four "water" enders | 29 |
| Four ''fish'' | 29 |
| Fountains, in heraldry | 22 |
| Fountain treats for bigwigs? | 28 |
| Fountain treat, for short | 25 |
| Fountain setting, perhaps | 25 |
| Fountain pen, to François | 28 |
| Fountain pen's tip | 22 |
| Fountain offering, perhaps | 26 |
| Fountain of Youth slogan? | 25 |
| Fountain of Trevi coin | 22 |
| Fountain of New Orleans | 23 |
| Fountain locale, often | 22 |
| Fountain in New Orleans | 23 |
| Fountain contents, often | 24 |
| Fountain basin feature | 22 |
| Founding New Yorker editor | 26 |
| Founding member of the Byrds | 28 |
| Founding member of OPEC | 23 |
| Founding member of NATO | 23 |
| Founding Fathers, e.g. | 22 |
| Founding Father, familiarly | 27 |
| Founding father Franklin | 24 |
| Founding editor of the O.E.D. | 29 |
| Founder of U. of Virginia | 25 |
| Founder of Time and Life | 24 |
| Founder of Thebes, in myth | 26 |
| Founder of the Tudor dynasty | 28 |
| Founder of the Soviet Union | 27 |
| Founder of the Shakers | 22 |
| Founder of the Russian empire | 29 |
| Founder of the Persian Empire | 29 |
| Founder of the Ottoman Empire | 29 |
| Founder of the Oratory | 22 |
| Founder of the Motown label | 27 |
| Founder of the Mongol dynasty | 29 |
| Founder of the Jesuits | 22 |
| Founder of The Factory | 22 |
| Founder of the Dutch Republic | 29 |
| Founder of the Chicago Bears | 28 |
| Founder of the Bolsheviks | 25 |
| Founder of Sunnybank Kennels | 28 |
| Founder of sumptuous hotels | 27 |
| Founder of Scholasticism | 24 |
| Founder of Reprise Records | 26 |
| Founder of psychoanalysis | 25 |
| Founder of Philadelphia | 23 |
| Founder of Persian Empire | 25 |
| Founder of Ottoman dynasty | 26 |
| Founder of Motown Records | 25 |
| Founder of modern Turkey | 24 |
| Founder of modern China | 23 |
| Founder of modern chemistry | 27 |