| Operation-launching times | 25 |
| Operational headquarters | 24 |
| Operative's employer | 24 |
| Operator of a metal plant | 25 |
| Operator of MouthHealthy.org | 28 |
| Operator's accessory | 24 |
| Operator's concern: Abbr. | 29 |
| Operator's number? | 22 |
| Operator's post, once | 25 |
| Operator's request | 22 |
| Operator's request? | 23 |
| Operators standing by? | 22 |
| Operetta composer Franz | 23 |
| Operetta princess and others | 28 |
| Operetta set in Titipu | 22 |
| Ophelia and Hamlet, e.g. | 24 |
| Ophelia or Claudius, e.g. | 25 |
| Ophelia or Laertes, e.g. | 24 |
| Ophelia's thought flower | 28 |
| Ophiologist's study | 23 |
| Ophthalmic concern (Var.) | 25 |
| Ophthalmic development | 22 |
| Ophthalmologic concern | 22 |
| Ophthalmologic problem | 22 |
| Ophthalmological concern | 24 |
| Ophthalmological study | 22 |
| Ophthalmologist's case | 26 |
| Ophthalmologist's cases | 27 |
| Ophthalmologist's concern | 29 |
| Ophthalmologist's office? | 29 |
| Ophthalmologist's order | 27 |
| Ophthalmologist's study | 27 |
| Ophthalmologist's supply | 28 |
| Ophthalmologist's tool | 26 |
| Opie Taylor's caretaker | 27 |
| Opie's answer to Aunt Bee | 29 |
| Opie, at the lake, sometimes | 28 |
| Opine, with "in" | 26 |
| Opinion column, briefly | 23 |
| Opinion of Keats poetry? | 24 |
| Opinion page perspective | 24 |
| Opinion piece by a sot? | 23 |
| Opinion piece, for short | 24 |
| Opinion piece, in Nice | 22 |
| Opinion sharer's remark | 27 |
| Opinion, after deflation? | 25 |
| Opinion, forward or backward | 28 |
| Opinions from a coward? | 23 |
| Opium poppies have them | 23 |
| Opium-derived analgesic | 23 |
| Opossum's branch grabber | 28 |
| Opp. of "take out" | 28 |
| Opp. of legato, in music | 24 |
| Oppenheimer development | 23 |
| Oppenheimer opposed it | 22 |
| Oppenheimer's agcy. | 23 |
| Oppenheimer's alma mater | 28 |
| Opponent for Bjorn or Vitas | 27 |
| Opponent for Juan Belmonte | 26 |
| Opponent for Minnesota Fats | 27 |
| Opponent in an argument | 23 |
| Opponent of George and Bill | 27 |
| Opponent of government | 22 |
| Opponent of Jimmy and Arthur | 28 |
| Opponent of Muhammad: 1978 | 26 |
| Opponent of the CAN-SPAM act | 28 |
| Opponent of U. S. Grant | 23 |
| Opponent's utterance | 24 |
| Opponents of 'us' | 25 |
| Opponents of "us" | 27 |
| Opportunist with tickets | 24 |
| Opportunities at home? | 22 |
| Opportunities at karaoke? | 25 |
| Opportunities for discussion | 28 |
| Opportunities for repentance | 28 |
| Opportunities to shine | 22 |
| Opportunities to speak so | 25 |
| Opportunities to swing | 22 |
| Opportunities, in metaphor | 26 |
| Opportunities, metaphorically | 29 |
| Opportunities, so to speak | 26 |
| Opportunity for privacy | 23 |
| Opportunity for trade? | 22 |
| Opportunity to learn to speak | 29 |
| Opportunity visited it | 22 |
| Opportunity's first step? | 29 |
| Opportunity's frequency | 27 |
| Opportunity, metaphorically | 27 |
| Opportunity, so to speak | 24 |
| Oppose, while tippling? | 23 |
| Opposed to to Pappy Yokum | 26 |
| OPPOSED TO A BANNER SHARE | 25 |
| Opposed to a cap on wages? | 26 |
| Opposed to armed conflict | 25 |
| Opposed to organized labor | 26 |
| Opposed to the Constitution | 27 |
| Opposed to the union, say | 25 |
| Opposed to, hillbilly-style | 27 |
| Opposed to, in Appalachia | 25 |
| Opposed to, in dialect | 22 |