| Seattle area code, archaically represented | 42 |
| Seattle sidewalk stuff, in mid-1980 | 35 |
| Seattle Slew, vis-Ã -vis Swale | 32 |
| Seattle Storm head coach Donovan | 32 |
| Seattle ___ (1977 Horse of the Year) | 36 |
| Seattle ___ (legendary racehorse) | 33 |
| Seattle ___ (legendary thoroughbred) | 36 |
| Seattle ___ (Triple Crown winner) | 33 |
| Seattle ___ (Triple Crown winner, 1977) | 39 |
| Seattle ___, the Triple Crown winner | 36 |
| Seattle ___, Triple Crown winner | 32 |
| Seattle's Best product, slangily | 36 |
| Seattle's summer setting (abbr.) | 36 |
| Seattle's third-largest company | 35 |
| Seaver's can reach 95 m.p.h. | 32 |
| Seaver's first baseball home | 32 |
| Seawater component, to a chemist | 32 |
| Seawater discolored by dinoflagellates | 38 |
| Seaweed extract used in fertilizers | 35 |
| Señor from Peru's capital | 32 |
| Señor Manolete's challenge | 33 |
| Señor ___ ("Casablanca" role) | 42 |
| Señor's "Absolutely!" | 38 |
| Señor's "Certainly!" | 37 |
| Señor's "Positively!" | 38 |
| Señor's "See ya!" | 34 |
| Señor's "Sure thing!" | 38 |
| Señor's blanketlike shawl | 32 |
| Señor's iterated approval | 32 |
| Señor's word when departing | 34 |
| Señora's "other" | 33 |
| Señora's "some" | 32 |
| Señora's "this" | 32 |
| Señorita's "Stop!" | 35 |
| Sebastian of "Family Affair" | 38 |
| Sebastian ___, record-breaking miler | 36 |
| SEC investigation target of 2005 | 32 |
| Sec. addition to a signed letter | 32 |
| Sec. of Agriculture: 1971–76 | 35 |
| Sec. of Commerce: 1969–72 | 32 |
| Sec. of the Interior: 1961–69 | 36 |
| Sec. of the Navy: 1939–40 | 32 |
| Secede from the Union, for example | 34 |
| Secessionist Governor Rick Perry, for one | 41 |
| Second "Star Trek" movie, informally | 46 |
| Second addendum to a letter, briefly | 36 |
| Second addendum to a letter: Abbr. | 34 |
| Second afterthought in a letter: Abbr. | 38 |
| Second Amendment advocate (abbr.) | 33 |
| Second Amendment advocates (abbr.) | 34 |
| Second Amendment defender: Abbr. | 32 |
| Second Amendment lobby, for short | 33 |
| Second Amendment promoter: Abbr. | 32 |
| Second Amendment supporter (Abbr.) | 34 |
| Second Amendment supporter: Abbr. | 33 |
| Second Amendment supporters: Abbr. | 34 |
| Second appearance on a soundtrack | 33 |
| Second avenue on a Monopoly board | 33 |
| Second baseman called "The Crab" | 42 |
| Second baseman for the Big Red Machine | 38 |
| Second careers for thoroughbreds | 32 |
| Second chance for couch potatoes | 32 |
| Second City transportation agcy. | 32 |
| Second Council of Constantinople year | 37 |
| Second dinner course at the prison? | 35 |
| Second division of an Italian sonnet | 36 |
| Second dog to play Eddie on "Frasier" | 47 |
| Second effort success, in basketball | 36 |
| Second film in a 2000s horror franchise | 39 |
| Second generation Japanese-American | 35 |
| Second half of a mountaineer's trip | 39 |
| Second half of a rhyming Beatles title | 38 |
| Second half of things we all memorized | 38 |
| Second highest in a family of instruments | 41 |
| Second highest, in a family of instruments | 42 |
| Second in a series of sharp turns | 33 |
| Second in a series of Web postings | 34 |
| Second in command in the state: Abbr. | 37 |
| Second Israeli ambassador to the U.S. | 37 |
| Second Israeli ambassador to U.S. | 33 |
| Second Jimi Hendrix Experience album | 36 |
| Second largest "Great Lake" | 37 |
| Second largest city in Nicaragua | 32 |
| Second largest city in the Czech Republic | 41 |
| Second largest Islam denomination | 33 |
| Second largest island in the world | 34 |
| Second largest of the Great Lakes | 34 |
| Second largest of the Great Lakes | 33 |
| Second largest retailer in the U.S. | 35 |
| Second largest theater chain in the U.S. | 40 |
| Second letter of the Greek alphabet | 35 |
| Second look, on "Monday Night Football" | 49 |
| Second Lt.'s Navy equivalent | 32 |
| Second miss in a hangman game, often | 36 |
| Second most common Korean surname | 33 |
| Second most populous Central American city | 42 |
| Second most populous city in Michigan | 37 |
| Second most populous city in Yemen | 34 |
| Second most populous continent: Abbr. | 37 |
| Second most populous Oklahoma city | 34 |