| The first one ruled 1547-84 | 27 |
| The first one pointed to? | 25 |
| The first one opened on Majorca in 1950 | 39 |
| The first one opened in Detroit in 1962 | 39 |
| The first one gets you going | 28 |
| The first one appeared on this date in 1913 | 43 |
| The first official one was November 11, 1919 | 44 |
| The first of Weird Al's 2014 parodies | 41 |
| The first of two | 16 |
| The first of several? | 21 |
| The first of September? | 23 |
| The first of many steps | 23 |
| The first of Judy's two daughters | 37 |
| The first of Judy's daughters | 33 |
| The first of Henry VIII's two Annes | 39 |
| The first of 13: Abbr. | 22 |
| The first odd prime number | 26 |
| The first O of O-O-O | 20 |
| The first Norwegian band with a number 1 song in the US | 55 |
| The first non-British to receive Britain's Dickin Medal for Gallantry was a _____ | 85 |
| The first natural number | 24 |
| The first N in CNN | 18 |
| The first multimillionaire | 26 |
| The first Mrs. Woodrow Wilson | 29 |
| The first Mrs. Trump | 20 |
| The first Mrs. Soames Forsyte | 29 |
| The first Mrs. Richard Wagner | 29 |
| The first Mrs. Donald Trump | 27 |
| The first Mrs. Copperfield | 26 |
| The first Mrs. Arrowsmith | 25 |
| The first Mr. Shirley Temple | 28 |
| The first mes | 13 |
| The first martyr, in Islam | 26 |
| The first manned Apollo mission | 31 |
| The first man, in Maori myth | 28 |
| The first man to fly in space twice | 35 |
| The first man in space | 22 |
| The first lover | 15 |
| The first letter of "tsar," in Cyrillic | 49 |
| The first letter of "circle" (but not the fourth) | 59 |
| The first letter of "cent," e.g. | 42 |
| The First Lady of Song, to fans | 31 |
| The first James Bond movie | 26 |
| The first James Bond film | 25 |
| The first installment | 21 |
| The first indication that I had one too many last night? | 56 |
| The first H in HRH, perhaps | 27 |
| The first glossy fabric? | 24 |
| The first four-minute mile, e.g.? | 33 |
| The first film it aired was "Gone with the Wind" | 58 |
| The first electric one was used in Paris in the 1870s | 53 |
| The first Cosby show | 20 |
| The first complete navigation of the Amazon was in search of this | 65 |
| The first chip, usually | 23 |
| The first century started when it ended | 39 |
| The first cardinal? | 19 |
| The first cardinal | 18 |
| The first canonical hour | 24 |
| The first C of CDC: abbr. | 25 |
| The first Bond girl | 19 |
| The first blank in the seafood restaurant sign "___ ___ season" | 73 |
| The first big brother | 21 |
| The first bad brother | 21 |
| The first B of B&B | 22 |
| The first Apple with an Intel chip | 34 |
| The first and last European colony in China | 43 |
| The first American woman in space | 33 |
| The first American to orbit the Earth | 37 |
| The first American in space | 27 |
| The first African-American woman in space | 41 |
| The first a in aka | 18 |
| The first "T" of TNT | 30 |
| The first "S" in S.S.R.: Abbr. | 40 |
| The first "S" in S.A.S.E. | 35 |
| The first "N" of CNN | 30 |
| The first "Mr. Shirley Temple" | 40 |
| The first "M" in MGM | 30 |
| The first "M" in M-G-M | 32 |
| The first "L" of L. L. Bean | 37 |
| The first "H" of H.H.S. | 33 |
| The first "H" in Hanukkah | 35 |
| The first "A" of A.A. Milne | 37 |
| The first "A" of A. A. Milne | 38 |
| The first "A" in N.A.A.C.P.: Abbr. | 44 |
| The first "a" in a k a | 32 |
| The first 'M' of MGM | 28 |
| The firmament | 13 |
| The Firm rapper | 15 |
| The fire station burned down, e.g. | 34 |
| The Finnish language | 20 |
| The Finn man | 12 |
| The finishing touch | 19 |
| The finish for Captain Nemo? | 28 |
| The finest | 10 |
| The finding of a Virgin Mary-shaped gummy candy, e.g. | 53 |
| The financial analyst brought ... | 33 |
| The final word, to theologists | 30 |
| The final word in storybooks | 28 |
| The final word | 14 |
| The final Mrs. Chaplin | 22 |