| Spielberg's young treasure hunters | 38 |
| Spike Lee's "Malcolm X," e.g. | 43 |
| Spike Lee's "She's ___ Have It" | 49 |
| Spike Lee's "Summer of ___" | 41 |
| Spike Lee's "___ Gotta Have It" | 45 |
| Spike Lee's "___ Man" | 35 |
| Spike sued to prevent its name change | 37 |
| Spike that tried to sue Spike TV | 32 |
| Spike who directed "Crooklyn" | 39 |
| Spike's victim, in "Nancy" comics | 47 |
| Spikes used by mountain climbers | 32 |
| Spiky device thrown in the road to puncture tires | 49 |
| Spill Canvas "Himerus and ___" | 40 |
| Spill coffee on a computer, maybe | 33 |
| Spill the info (with ''up'') | 44 |
| Spill the info (with "up") | 36 |
| Spillane classic that introduced Mike Hammer | 44 |
| Spillane's ''___ Jury'' | 43 |
| Spillane's "--- Jury" | 35 |
| Spillane's "__ Jury" | 34 |
| Spillane's "___ Jury" | 35 |
| Spillane's "_____ Jury" | 37 |
| Spilling one's drink at a shindig, for one | 46 |
| Spilling salt and breaking a mirror, say | 40 |
| Spillover space, or a wedding sub? | 34 |
| Spin a different Arab leader around? | 36 |
| Spin Doctors "Cleopatra's ___" | 44 |
| Spin Doctors "What Time ___?" | 39 |
| Spin Doctors "___ Full of Kryptonite" | 47 |
| Spin imparted to a billiard ball | 32 |
| Spin of the dial or roll of the dice | 36 |
| Spin-o-___ (360-degree hockey maneuver) | 39 |
| Spin-off featuring Tom Selleck's mini-me? | 45 |
| Spin-off of "Hercules" | 32 |
| Spin-off of CBS's "JAG" | 37 |
| Spin-off starring Valerie Harper | 32 |
| Spinal segment that may become slipped | 38 |
| Spiner of "Star Trek: T.N.G." | 39 |
| Spiner of "Star Trek: TNG" | 36 |
| Spingarn of the N.A.A.C.P.'s Spingarn Medal | 47 |
| Spinks's opponent in two title fights | 41 |
| Spinks's way to lose weight? | 32 |
| Spinner seen in an online video? | 32 |
| Spinning device giving the illusion of motion | 45 |
| Spinning plates on a stick, e.g. | 32 |
| Spinning thing on a tricked-out car | 35 |
| Spinning toy manipulated with sticks | 36 |
| Spinoff of "Beavis and Butt-Head" | 43 |
| Spinoff of "The Dukes of Hazzard" | 43 |
| Spinoff of "The Mary Tyler Moore Show" | 48 |
| Spinoff of CBS's "JAG" | 36 |
| Spinoff of TV's "Hercules" | 40 |
| Spiny shrub common on links courses | 35 |
| Spiny, yellow-green, tart-tasting fruits | 40 |
| Spiny-rayed fishes popular in aquariums | 39 |
| Spiral shells often used as horns | 33 |
| Spiral-shaped particle accelerators | 35 |
| Spiraled-horned African antelope | 32 |
| Spirit from Mars is still going? | 32 |
| Spirit in ''The Tempest'' | 41 |
| Spirit in "The Tempest" | 33 |
| Spirit in which something may be spoken | 39 |
| Spirit of "The Tempest" | 33 |
| Spirited mount [SEE NOTE WINDOW] | 32 |
| Spirited steps around a sombrero | 32 |
| Spirits brand with a Peppar variety | 35 |
| Spirits from a Massachusetts university? | 40 |
| Spirits that victimize the sleeping | 35 |
| Spiritual adviser's entrée? | 34 |
| Spiritual board marketed by Parker Brothers | 43 |
| Spiritual interpretation of Scripture | 37 |
| Spiritual leader of Firenze: 1494 | 33 |
| Spiritual leader of the Isma'ili Muslims | 44 |
| Spiritual music LP goes awry (6) | 32 |
| Spiritual order with a Quanzhen School | 38 |
| Spiritual World of Warcraft class | 33 |
| Spiro Agnew's plea, for short | 33 |
| Spit-influenced "Always" band? | 40 |
| Spitzer who succeeded Pataki as New York governor | 49 |
| Spitzer's replacement as Attorney General | 45 |
| Splasher of those seated in the first seven rows | 48 |
| Splashing source on the Colorado | 32 |
| Splashy 1963 film title role, for short | 39 |
| Split a bill evenly with someone | 32 |
| Split for the sole purpose of uniting? | 38 |
| Split with one's girlfriend, perhaps? | 41 |
| Split ___ (1970s-80s New Zealand band) | 38 |
| Splitting ___ (prehistoric tool) | 32 |
| Splitting, in 1920s slang, to ancient Romans | 44 |
| Spock's father in "Star Trek" | 43 |
| Spock's mother in "Star Trek" | 43 |
| Spoil (with ''on'') | 35 |
| Spoiled a good walk, per Mark Twain | 35 |
| Spoiled, with ''on'' | 36 |
| Spoiler of a parade for Ahmadinejad? | 36 |
| Spoiler of a princess's sleep | 33 |
| Spoilers of Mrs. Murphy's chowder | 37 |
| Spoke like an uninspired lecturer | 33 |
| Spoke lyrics to audience before playing | 39 |
| Spoke so as to put people to sleep | 34 |