| Southern campus on the Mississippi R. | 37 |
| Southern campus where Shaq played basketball | 44 |
| Southern capital with a French name | 35 |
| Southern Caribbean island known for scuba diving | 48 |
| Southern city nickname, with "the" | 44 |
| Southern college nickname: ___ Miss | 35 |
| Southern constellation near Telescopium | 39 |
| Southern cousin of bouillabaisse | 32 |
| Southern crop, from an economic standpoint | 42 |
| Southern Florida coastal resort city | 36 |
| Southern gospel group the ___ Family | 36 |
| Southern Hemisphere constellation | 33 |
| Southern Hemisphere imaginary line | 34 |
| Southern historical novelist Price | 34 |
| Southern lady's salutation, stereotypically | 47 |
| Southern Methodist team, with "the" | 45 |
| Southern Mexico tourist destination | 35 |
| Southern neighbor of British Columbia | 37 |
| Southern nickname, after "the" | 40 |
| Southern Pacific and others: Abbr. | 34 |
| Southern sch. whose colors are purple and gold | 46 |
| Southern school Martin Ritt attended | 36 |
| Southern university founded in 1848 | 35 |
| Southern vegetable that's often deep-fried | 46 |
| Southern writer William Gilmore ___ | 35 |
| Southern, French and Cockney, for three | 39 |
| Southernmost Arabian peninsular country | 39 |
| Southernmost capital on the Arabian Peninsula | 45 |
| Southernmost city of ancient Palestine | 38 |
| Southernmost city of the Lower 48 | 33 |
| Southernmost coast-to-coast rte. | 32 |
| Southernmost country in Central America | 39 |
| Southernmost cross-country U.S. highway | 39 |
| Southernmost tip of South America | 33 |
| Southey's "The Curse of Kehama" | 45 |
| Southey's "___ of Kehama" | 39 |
| Southpaw pitcher Jim who won 16 Gold Gloves | 43 |
| Southpaw's haymakers, probably | 34 |
| Southwark, Vauxhall and Waterloo | 32 |
| Southwest Africa's ___ Desert | 33 |
| Southwest alternative, for short | 32 |
| Southwest Arizona's ___ Desert | 34 |
| Southwest chips-and-chili snacks | 32 |
| Southwest city founded by Mormon pioneers | 41 |
| Southwest desert that includes Death Valley | 43 |
| Southwest sch. whose mascot is King Triton | 42 |
| Southwestern city founded by Mormons | 36 |
| Southwestern gathering for folk dances | 38 |
| Southwestern geographical features | 34 |
| Southwestern livestock threatener | 33 |
| Southwestern shrubs yielding a cosmetic oil | 43 |
| Southwestern site of gypsum dunes | 33 |
| Souvenir at the NFL's big event? | 36 |
| Souvenir for the farmer's wife? | 35 |
| Souvenir from a tropical vacation? | 34 |
| Souvenir from the Petrified Forest? | 35 |
| Souvenir hunter who frequents smoky bars? | 41 |
| Souvenirs from the Worldwide Texas Tour? | 40 |
| Sovereign of the Mongol empire in India | 39 |
| Sovereign territory, synecdochically | 36 |
| Sovereign's 'I,' often | 34 |
| Soviet agency created from Rosta | 32 |
| Soviet anti-spy group in some James Bond novels | 47 |
| Soviet dissident-author Sharansky | 33 |
| Soviet economic program begun in '88 | 40 |
| Soviet leader who signed SALT I and II | 38 |
| Soviet Literature Nobelist Bunin | 32 |
| Soviet nuclear physicist Kurchatov | 34 |
| Soviet org. in James Bond stories | 33 |
| Soviet Physics Nobelist ___ Tamm | 32 |
| Soviet president: 1923–46 | 32 |
| Soviet spy Rudolf and actor Walter | 34 |
| Soviet spymaster in a John le Carré trilogy | 46 |
| Soviet W.W. II foreign affairs commissar | 40 |
| Soy, north of the Mexican border | 32 |
| Soybean appetizer served at sushi bars | 38 |
| Soyer's "Girl in a White ___" | 43 |
| Sp-[gasp]-speaks like th-[sniffle]-this | 39 |
| Sp. currency replaced by the euro | 33 |
| Spa employee, generally speaking | 32 |
| Spa in France's Haute-Savoie department | 43 |
| Spa offering that's not quite godlike? | 42 |
| Spa visitor who doesn't pay the bill? | 41 |
| Space bar neighbor, on some keyboards | 37 |
| Space between a bird's eye and bill | 39 |
| Space between a leaf and its supporting stem | 44 |
| Space between a leaf's veins | 32 |
| Space between dotted lines, maybe | 33 |
| Space between the eye and the bill | 34 |
| Space between the eye and the bill of a bird | 44 |
| Space cartoon set in the year 3000 | 34 |
| Space film (with "The") | 33 |
| Space flight's starting point | 33 |
| Space found in Who-Turned-Out-the-Lights-opoly? | 47 |
| Space laser program of the '80s | 35 |
| Space Mountain and Splash Mountain | 34 |
| Space needed to store a character of text | 41 |
| Space object with an event horizon | 34 |
| Space station assignment, for short | 35 |
| Space station for about 15 years | 32 |