| South America's largest country | 35 |
| South America's RÃo de la __ | 35 |
| South America's smallest country | 36 |
| South America's third-largest nation | 40 |
| South American animal with a snout | 34 |
| South American bird named for a Greek Titan | 43 |
| South American capital at 12,000 feet | 37 |
| South American capital located in a desert | 42 |
| South American carrier founded in 1927 | 38 |
| South American city of 2 million | 32 |
| South American country at 0 degrees lat. | 40 |
| South American country with a red-and-white flag | 48 |
| South American cruise stop, for short | 37 |
| South American freshwater shockers | 34 |
| South American grilled meat dish | 32 |
| South American monkey with a long tail | 38 |
| South American opening trendy lunch dish (5) | 44 |
| South American river in an Enya song title | 42 |
| South American shrubs with potent leaves | 40 |
| South American singer/French writer | 35 |
| South American state capital city | 33 |
| South American's ear of corn | 32 |
| South Australia's state gemstone | 36 |
| South by Southwest Festival Texas city | 38 |
| South Carolina band's compass point | 39 |
| South Carolina city or university | 33 |
| South Carolina county or its seat | 33 |
| South Carolina river to the Atlantic | 36 |
| South Carolina women's school | 33 |
| South Carolina's chief river | 32 |
| South Carolina's ___ Dee River | 34 |
| South Dakota and Pennsylvania cities merge? | 43 |
| South Dakota geographical feature | 33 |
| South Dakota's ___ National Park | 36 |
| South Dakota/Nevada/ Virginia tri-city area? | 44 |
| South Florida vacation destination | 34 |
| South Georgia's Prince ___ Harbor | 37 |
| South Korea's first president | 33 |
| South Korea's first president Syngman ___ | 45 |
| South Korea's fourth-largest company | 40 |
| South Korea's largest port, formerly | 40 |
| South Korea's national sport | 32 |
| South Korea's second largest city | 37 |
| South Korea's second-largest city | 37 |
| South Korean president, 1948-1960 | 33 |
| South Korean president: 1948–60 | 38 |
| South Pacific archipelago and nation | 36 |
| South Pacific country whose capital is Apia | 43 |
| South Pacific island where Gauguin lived | 40 |
| South Pacific islands, collectively | 35 |
| South Pacific nation with about 100,000 people | 46 |
| South Pacific site of large stone statues | 41 |
| South Pole continent, with "the" | 42 |
| South Seas entrepreneur going over his holdings? | 48 |
| South Side squad, briefly, with "the" | 47 |
| South Vietnam president, 1967-75 | 32 |
| South Vietnam's first president ___ Dinh Diem | 49 |
| South Vietnam's last president | 34 |
| South Vietnam's Ngo Dinh ___ | 32 |
| South Vietnam's ___ Dinh Diem | 33 |
| South Vietnamese president until 1975 | 37 |
| South __, MA (Mount Holyoke locale) | 35 |
| South ___ (country surrounding Lesotho) | 39 |
| South ___ (Kiribati's capital) | 34 |
| South's declaration, perhaps | 32 |
| South-central border town portmanteau | 37 |
| South-of-the-border border town portmanteau | 43 |
| South-of-the-border cheer starter | 33 |
| South-of-the-border dance musicians | 35 |
| South-of-the-border encouragement | 33 |
| South-of-the-border order, perhaps | 34 |
| South-of-the-border political assent? | 37 |
| South-of-the-border spouses, briefly | 36 |
| South-of-the-border spouses: Abbr. | 34 |
| South-of-the-border title: Abbr. | 32 |
| South: asks that the bid be recorded | 36 |
| Southampton Graduate Campus sch. | 32 |
| Southeast Asia's only landlocked nation | 43 |
| Southeast Asia's __ Peninsula | 33 |
| Southeast Asian country where you can spend kips | 48 |
| Southeast Asian country, familiarly | 35 |
| Southeast Asian fruits with large, thick spines | 47 |
| Southeast Asian island metropolis | 33 |
| Southeast-most county of Ireland, or its seat | 45 |
| Southeastern Conference collegian | 33 |
| Southeastern Conference powerhouse | 34 |
| Southeastern Conference team, for short | 39 |
| Southeastern Conference team, informally | 40 |
| Southern accent giveaway, perhaps | 33 |
| Southern African mammal that stands sentry | 42 |
| Southern Arabian Peninsula country | 34 |
| Southern Australia's _____ Bay | 34 |
| Southern belle's cry of surprise | 36 |
| Southern border of the Northwest Territory | 42 |
| Southern British Columbia community | 35 |
| Southern California basket maker | 32 |
| Southern California festival town | 33 |
| Southern California's Santa __ Mountains | 44 |
| Southern California's Santa ___ winds | 41 |
| Southern California's __ Sea | 32 |