| Sobriquet for Charles V, with "the" | 45 |
| Sobriquet for singer John Phillips | 34 |
| Sobriquet for the 2007 MLB home run leader | 42 |
| Sobriquet for Wayne, Jon, or Kim | 32 |
| Sobriquet for William Henry Harrison | 36 |
| Soccer feature in Buddhist lands? | 33 |
| Soccer mom's "nothing" | 36 |
| Soccer mom's wheels, stereotypically | 40 |
| Soccer player Suárez known to bite opponents | 47 |
| Soccer player who does the least running | 40 |
| Soccer player who scored his first goal at age 14 | 49 |
| Soccer player's jersey, for short | 37 |
| Soccer players who can use their hands | 38 |
| Soccer rarity, it sometimes seems | 33 |
| Soccer star David committed a hand ball? | 40 |
| Soccer star who wrote "Go for the Goal" | 49 |
| Soccer star with his name on a video game title | 47 |
| Soccer star's broadcast medium? | 35 |
| Soccer star's favorite type of shoe? | 40 |
| Soccer team nicknamed the Black-and-Red | 39 |
| Soccer team on which phenom Freddy Adu plays | 44 |
| Soccer's Edson Arantes do Nascimento | 40 |
| Soccer-playing wife of baseball player Nomar | 44 |
| Social activity on a military base? | 35 |
| Social butterfly's flower pot? | 34 |
| Social crème de la crème | 38 |
| Social D "___ Between Heaven and Hell" | 48 |
| Social D "___ of My Life" | 35 |
| Social Distortion "___ Be Me" | 39 |
| Social Distortion singer/guitarist Mike | 39 |
| Social division of Hindu society | 32 |
| Social events at which dominoes are worn | 40 |
| Social gathering for auction participants? | 42 |
| Social gathering with the Rockettes? | 36 |
| Social instability due to a breakdown in values | 47 |
| Social media site that launched in 2003 | 39 |
| Social network for short messages | 33 |
| Social networking site for Jamaican sailors? | 44 |
| Social networking site for pig farmers? | 39 |
| Social one's ''gift'' | 41 |
| Social one's "gift" | 33 |
| Social organization for a browbeater? | 37 |
| Social planning site with a pre-Facebook heyday | 47 |
| Social psychology pioneer Solomon | 33 |
| Social reformer Wells and others | 32 |
| Social reformer: 1849–1914 | 33 |
| Social Security's parent program | 36 |
| Socialist Bolivian president Morales | 36 |
| Socialist Debs's middle name | 32 |
| Socialist Eugene who ran for President five times | 49 |
| Socialist labor leader: 1855–1926 | 40 |
| Socialist politico Eugene V. ___ | 32 |
| Socialite who inspired "Call Me Madam" | 48 |
| Socialite with a self-named perfume | 35 |
| Socialite's ''bye'' | 39 |
| Socialite's clothing initials | 33 |
| Socialites' five-time candidate? | 36 |
| Socialites' sources of income | 33 |
| Socializer's "gift" | 33 |
| Socializes for business purposes | 32 |
| Socially inept person, in British slang | 39 |
| Socials with cucumber sandwiches | 32 |
| Society for Psychical Research subj. | 36 |
| Society of Individual Psychology founder | 40 |
| Society of Jesus founder ___ López de Loyola | 47 |
| Society people like me have no shot of joining | 46 |
| Society's collective attitude | 33 |
| Society's newcomers, for short | 34 |
| Socioeconomic information disparity | 35 |
| Sociologist Durkheim and author Zola | 36 |
| Sock puppeteer Lewis and actress Belafonte | 42 |
| Sock-in-the-gut responses, in comics | 36 |
| Socks with diamond-shaped patterns | 34 |
| Socrates, in "Willard" | 32 |
| Socratic ___ (feigned ignorance in a discussion) | 48 |
| Socratic ___ (pretended ignorance) | 34 |
| Soda born at the base of a California mountain | 46 |
| Soda brand "reintroduced" in July 1985 | 48 |
| Soda brand seen on "MASH" reruns | 42 |
| Soda jerk's dress-up attire? | 32 |
| Soda originally named Brad's Drink | 38 |
| Soda reportedly named for a bottle size | 39 |
| Soda that sounds like a stocking | 32 |
| Sodas chugged on "MASH" | 33 |
| Sodium chloride in our home chemistry set | 41 |
| Sodium hydroxide in our home chemistry set | 42 |
| Sodium hydroxide, in chem. class | 32 |
| Sodium hydroxide, in lab shorthand | 34 |
| Sodium hydroxide, on a chem test | 32 |
| Sodium hydroxide, to a chem major | 33 |
| Sodium __: salt used in airbag systems | 38 |
| Sodium ___ (potato chip flavoring) | 34 |
| Soekarno-Hatta International Airport city | 41 |
| Soekarno–Hatta International Airport city | 45 |
| Sofa part with an island within? | 32 |
| Sofa where the sausages get stuffed? | 36 |
| Sofer of "Blind Justice" | 34 |
| Sofer of "General Hospital" | 37 |
| Sofia Coppola's aunt ___ Shire | 34 |
| Sofia in "The Color Purple" | 37 |