| Sienkiewicz's "Quo ___?" | 38 |
| Sierra Club's first president | 33 |
| Sierra follower, in the NATO alphabet | 37 |
| Sierra Nevada peak, with "El" | 39 |
| Sierra __: Freetown's country | 33 |
| Sierra ___ (Freetown's country) | 35 |
| Siesta taken by this puzzle's longest answers | 49 |
| Sieved food to a certain consistency | 36 |
| Sigfried's performing partner | 33 |
| Sighed line from one just sidelined | 35 |
| Sight a sightseer sees in Sicily | 32 |
| Sight at a backstabbing family reunion? | 39 |
| Sight at a fraternity party, perhaps | 36 |
| Sight at a shirts vs. skins game | 32 |
| Sight at a supermarket or golf course | 37 |
| Sight between Tucson and Phoenix | 32 |
| Sight caused by atmospheric dust | 32 |
| Sight for a sailor's sore eyes | 34 |
| Sight from N.C.'s Outer Banks | 33 |
| Sight from New York's Grand Central Parkway | 47 |
| Sight from St. Peter's Square | 33 |
| Sight from the cuckoo's nest? | 33 |
| Sight from the Golden Gate Bridge | 33 |
| Sight from the Indian Ocean, perhaps | 36 |
| Sight from the Rock and Roll Hall of Fame | 41 |
| Sight from the Sicilian village of Taormina | 43 |
| Sight in ''The X Files'' | 40 |
| Sight in a botanist's horror movie? | 39 |
| Sight in a Stockholm parking lot | 32 |
| Sight in Canyonlands National Park | 34 |
| Sight in St. Peter's Basilica | 33 |
| Sight on a "Hee Haw" set | 34 |
| Sight on a courthouse pole (abbr.) | 34 |
| Sight on much old Roman statuary | 32 |
| Sight outside the Dorothy Chandler Pavilion | 43 |
| Sight seen through the HP factory windows? | 42 |
| Sight you might see outside of M's office? | 46 |
| Sighter of the Pacific Ocean, 1513 | 34 |
| Sighter of the Pacific, 9/25/1513 | 33 |
| Sighter of the Pacific, Sept. 25, 1513 | 38 |
| Sighting at a punk rock concert, maybe | 38 |
| Sighting from the crow's-nest | 33 |
| Sighting in the Pacific Northwest | 33 |
| Sighting in the Scottish Highlands | 34 |
| Sighting off the California coast | 33 |
| Sightings the U.S.A.F. may investigate | 38 |
| Sights at the dentist's office | 34 |
| Sights in an intensive care unit | 32 |
| Sights in Charleston and Brooklyn | 33 |
| Sights on Third Avenue in the mid-20th century | 46 |
| Sights seen ahead in a traffic jam | 34 |
| Sights, as from the Eiffel Tower | 32 |
| Sightseeing destination, to a May baby? | 39 |
| Sightseeing trip for burglars? Woof! | 36 |
| Siglo de ___ (cultural epoch in Spain) | 38 |
| Siglo de ___ (epoch of Cervantes) | 33 |
| Sign abbr. meaning "founded in" | 41 |
| Sign about a space shortage, briefly | 36 |
| Sign accompanied by "Keep Out" | 40 |
| Sign akin to "For Sale" | 33 |
| Sign at a bicycle shop or boardinghouse | 39 |
| Sign at a neighborhood bar, part 1 | 34 |
| Sign at a store with a hard-to-find item | 40 |
| Sign at an auto repair shop (Part 1) | 36 |
| Sign at an auto repair shop (Part 2) | 36 |
| Sign at an auto repair shop (Part 3) | 36 |
| Sign at the end of a freeway, maybe | 35 |
| Sign at the Three Seasons Hotel? | 32 |
| Sign at the Ukrainian tourism bureau? | 37 |
| Sign either to talk or to be quiet | 34 |
| Sign for a factory with tripled capacity? | 41 |
| Sign for a recovering alcoholic? | 32 |
| Sign for one born on Cinco de Mayo | 34 |
| Sign for tourists visiting the Bolshoi? | 39 |
| Sign glimpsed on televised games | 32 |
| Sign heading with a picture of a dog on it | 42 |
| Sign in some dry cleaners' windows | 38 |
| Sign in Spider-Man's kitchen? | 33 |
| Sign indicating a sold-out performance | 38 |
| Sign it's time to throw food out | 36 |
| Sign it's time to throw something out | 41 |
| Sign language communicator, maybe | 33 |
| Sign language pioneer Abbé de l'___ | 42 |
| Sign leading to a bunch of antlers? | 35 |
| Sign like "Give 'em a brake" | 42 |
| Sign of a clogged toilet, perhaps | 33 |
| Sign of a difficult corporate decision? | 39 |
| Sign of a sloop passing through customs? | 40 |
| Sign of an indifferent homemaker | 32 |
| Sign of being a non-native speaker | 34 |
| Sign of burnout hidden in eight puzzle answers | 46 |
| Sign of family leadership, maybe | 32 |
| Sign of impending trouble, maybe | 32 |
| Sign of impending trouble, perhaps | 34 |
| Sign of impending trouble, to some | 34 |
| Sign of nighttime entertainment? | 32 |
| Sign of parenthood in the mid-1980s | 35 |
| Sign of severe altitude sickness | 32 |
| Sign of spring in four places in this puzzle | 44 |
| Sign of spring, hidden four times in this puzzle | 48 |