| Series set in the California town of Agrestic | 45 |
| Series set on a mysterious island | 33 |
| Series that aired its final episode in May 2010 | 47 |
| Series with an upcoming Episode VII | 35 |
| Series with Capt. Picard, to fans | 33 |
| Series with detective Mac Taylor | 32 |
| Serious problem when planning an air force? | 43 |
| Serious trouble ahead, with "the" | 43 |
| Seriously break the trust of, slangily | 38 |
| Seriously irritate, based on Verdi? | 35 |
| Seriously restrained, as a prisoner | 35 |
| Seriously susceptible to sunburn | 32 |
| Serling of "The Twilight Zone" | 40 |
| Sermon starter or ender, perhaps | 32 |
| Serpent deity group, in Hinduism (in RUN AGAINST) | 49 |
| Serpent on a pharaoh's crown | 32 |
| Serpent's offering in Genesis | 33 |
| Servant for taverns, e.g.: Abbr. | 32 |
| Servant in "The Pink Panther" | 39 |
| Servant in the "Discworld" novels | 43 |
| Servant's supervisor on an estate | 37 |
| Serve that can't be returned | 32 |
| Serve, with ''out'' | 35 |
| Served as a baseball game official | 34 |
| Served in cream sauce and mushrooms | 35 |
| Served in its natural gravy, as roast beef | 42 |
| Served on fire, as cherries jubilee | 35 |
| Served over pasta with sherry and cream sauce | 45 |
| Served over toast, in diner lingo | 33 |
| Served with a certain spaghetti sauce | 37 |
| Served with a creamy cheese sauce | 33 |
| Server in the cafeteria of Mordor? | 34 |
| Server of Duff Beer to Homer Simpson | 36 |
| Server of food that may be steamed, fried or raw | 48 |
| Servers' boss, when followed by d' | 42 |
| Service academy's victory cry? | 34 |
| Service at Staples or FedEx Office | 34 |
| Service entrance location, sometimes | 36 |
| Service group that began as the Jolly Corks | 43 |
| Service org. since the 1850's | 33 |
| Service persons back from a tour of duty | 40 |
| Service pieces for an afternoon party | 37 |
| Service provided at Meineke and Pep Boys | 40 |
| Service providers to Martha's Vineyard, e.g. | 48 |
| Service station feature, briefly | 32 |
| Service station freebie, sometimes | 34 |
| Service that lets you buy a PlayStation quickly? | 48 |
| Service that makes people nervous | 33 |
| Service where there isn't a nearby P.O. | 43 |
| Service whose users look forward to their bills | 47 |
| Service's "The Law of the ___" | 44 |
| Service-academy boss, informally | 32 |
| Serving between appetizer and dessert | 37 |
| Serving dish used on Thanksgiving | 33 |
| Serving in "Nicholas Nickleby" | 40 |
| Serving in Homer Simpson's favorite dinner | 46 |
| Serving of ice in a beer hall drink? | 36 |
| Serving whiz on the tennis court | 32 |
| Servings of mashed potatoes, e.g. | 33 |
| Sesame seed and honey confection | 32 |
| Sesame seed and honey confection (Var.) | 39 |
| Session after a lecture, informally | 35 |
| Session-starting student seatwork | 33 |
| Set an Oscar-winning director at a slant? | 41 |
| Set aside chips for specific poker hands? | 41 |
| Set aside for a particular purpose | 34 |
| Set aside, as by higher authority | 33 |
| Set at the proper level, as a work force | 40 |
| Set at the same time, as watches | 32 |
| Set back to the beginning, as a tape | 36 |
| Set costs of articles before retailing | 38 |
| Set in "Die Fledermaus" | 33 |
| Set of chess moves also called the Ruy Lopez | 44 |
| Set of classes all students must take | 37 |
| Set of drums or first aid supplies | 34 |
| Set of half of the positive integers | 36 |
| Set of large percussion instruments | 35 |
| Set of parts that need assembling | 33 |
| Set of principles we must all live by | 37 |
| Set of questions about yesterday's lesson | 45 |
| Set of recovery rooms, for short | 32 |
| Set of shot glasses for Christmas? | 34 |
| Set of small stairs over a fence | 32 |
| Set of teaching practices introduced in the 1960s | 49 |
| Set of unprepared material, perhaps | 35 |
| Set one's sights on, with "at" | 44 |
| Set the record straight on something personal | 45 |
| Set the VCR for "Soul Train"? | 39 |
| Set things right again, after a body-snatching | 46 |
| Set to drive (with ''up'') | 42 |
| Set up camp (with a hidden fruit) | 33 |
| Set with a sharper picture, briefly | 35 |
| Set young trees among existing ones | 35 |
| Seth MacFarlane, at the 2013 Oscars, e.g. | 41 |
| Seth MacFarlane, at the 2013 Oscars | 39 |
| Seth of "Zack and Miri Make a Porno" | 46 |
| Seth who does "Weekend Update" | 40 |
| Seth's son that he fathered at age 105 | 42 |
| Sethe portrayer in "Beloved" | 38 |
| Seton Hall graduates in programming? | 36 |