| Sedaka's "Next Door to ___" | 41 |
| Sedaris of "Strangers With Candy" | 43 |
| Sedative target, with "the" | 37 |
| Sedgwick in Andy Warhol's short films | 41 |
| Sedgwick of 'The Closer' | 32 |
| Sedgwick of "The Closer" | 34 |
| Sedgwick of Andy Warhol's Factory | 37 |
| Sedgwick portrayed in "Factory Girl" | 46 |
| Sedimentary rocks resembling cemented fish roe | 46 |
| Seductress in the "Odyssey" | 37 |
| See by chance, with "upon" | 36 |
| See if a purchase can be charged | 32 |
| See red, talk a blue streak, etc. | 33 |
| See socially (with "with") | 36 |
| See some friends at the bar, say | 32 |
| Seed covering (or backward, pre-euro money) | 43 |
| Seed drill inventor for whom a band is named | 44 |
| Seed with a flavor like licorice | 32 |
| Seed's protective outer layer | 33 |
| Seed-spiller of the Old Testament | 33 |
| Seeds used in the Vietnamese dish pho | 37 |
| Seeds, before they're ripened | 33 |
| Seedy bar that's really rank? | 33 |
| Seedy bread that sells like hotcakes? | 37 |
| Seedy hangout across the Atlantic? | 34 |
| Seeger's old folk-singing group | 35 |
| Seeing Eye dogs often and briefly | 35 |
| Seeing man as focus of the universe | 35 |
| Seeing two of the same thing, literally | 39 |
| Seek at random, with "for" | 36 |
| Seek immediate medical assistance, in a way | 43 |
| Seek slyly, with "for" | 32 |
| Seek status by mentioning, as a name | 36 |
| Seek support from the Old Dominion State? | 41 |
| Seek the land's highest office | 34 |
| Seeker of certain precious materials | 36 |
| Seeker of perfection; innovator's agenda? | 45 |
| Seeker of subversives: 1938–44 | 37 |
| Seeker of the Seven Cities of Gold | 34 |
| Seeker's target in a kid's game | 39 |
| Seekers of the lost, strayed or stolen | 38 |
| Seeking the right women's tennis attire? | 44 |
| Seeks fair treatment, doctor-style? | 35 |
| Seeks help online, in portmanteau slang | 39 |
| Seeks legal redress with stunning effect? | 41 |
| Seeks the rough age of a fossil, perhaps | 40 |
| Seem less important in comparison | 33 |
| Seemed familiar, to a campanologist? | 36 |
| Seeming displacement, to astronomers | 36 |
| Seeming intersection of earth and sky | 37 |
| Seemingly friendly act of betrayal | 34 |
| Seemingly more-favorable conditions | 35 |
| Seemingly self-contradictory figures of speech | 46 |
| Seemingly unfitting name for Wrigley Field vines | 48 |
| Seems reasonable, with "up" | 37 |
| Seep slowly, as ketchup from a bottle | 37 |
| Seer who understood animals' voices | 39 |
| Seer who was Cassandra's brother | 36 |
| Seer's "revelation" | 33 |
| Sees the point of the discussion? | 33 |
| Seesaw sitter of tongue-twisterdom | 34 |
| Seether "___ and Effect" | 34 |
| Sega competitor in the 16-bit market | 36 |
| Sega Genesis competitor, initially | 34 |
| Sega racing classic with a Ferrari | 34 |
| Segal who wrote "Love Story" | 38 |
| Segal's "Oliver's ___" | 40 |
| Segal's "___ Story" | 33 |
| Seger "The Fire Down ___" | 35 |
| Seger's "Still The ___" | 37 |
| Seger: "___ it Shines" | 32 |
| Segment covered by a test, perhaps | 34 |
| Segment from "The Nutcracker" | 39 |
| Segment of Dante's "Inferno"? | 43 |
| Segments of "Silent Movie"? | 37 |
| Segue to a surprise story ending | 32 |
| Segues in a '50s-'60s sitcom? | 37 |
| Segundo matrimonio result, maybe? | 33 |
| Seigneur de Montaigne's output | 34 |
| Seiji Ozawa led it for nearly 30 yrs. | 37 |
| Seiji ___, longtime Boston Symphony maestro | 43 |
| Seinfeld and Chris Rock, for two | 32 |
| Seinfeld animated film of '07 | 33 |
| Seinfeld dad, on "Seinfeld" | 37 |
| Seinfeld's "sworn enemy" | 38 |
| Seinfeld's eccentric relative | 33 |
| Seinfeld's Uncle Leo portrayer __ Lesser | 44 |
| Seinfeld, Carrey, Rock, collectively | 36 |
| Seismologist rose to new heights? | 33 |
| Seismologist's prefix for center | 36 |
| Seize the opportunity, sunshinewise | 35 |
| Seized an opportunity to gain advantage | 39 |
| Seizes and devours, with "on" | 39 |
| Select "The Karate Kid" Oscar nominee? | 48 |
| Select a 1918 Billy Murray song? | 32 |
| Select a winner in a sweepstakes | 32 |
| Select group, with "the" | 34 |
| Select neighbor, on old controllers | 35 |
| Select one's jousting weapon? | 33 |
| Select the best and leave the rest | 34 |