| Region bordered by the Euphrates | 32 |
| Region bordering the South China Sea | 36 |
| Region colonized by Greeks in 11th century B.C. | 47 |
| Region conquered by Philip II of Macedon | 40 |
| Region from Libya to Afghanistan | 32 |
| Region from the Nile to the Red Sea | 35 |
| Region in Dante's "Inferno" | 41 |
| Region in Ecuador east of the Andes | 35 |
| Region in Robert W. Service's poems | 39 |
| Region including Prince Edward Island | 37 |
| Region including the Arabian Peninsula | 38 |
| Region just south of the Altai mountains | 40 |
| Region known as the Valley of the Moon | 38 |
| Region next to Afghanistan on a Risk board | 42 |
| Region of calms in the northern Atlantic | 40 |
| Region of Greece containing the capital | 39 |
| Region of heavy W.W. II fighting | 32 |
| Region of India known for black tea | 35 |
| Region of Italy that includes Rome | 34 |
| Region of Malaysia in northeastern Borneo | 41 |
| Region of northern South America | 32 |
| Region of simple, quiet pleasure | 32 |
| Region of southern England on the English Channel | 49 |
| Region of southwest Saudi Arabia | 32 |
| Region of Spain (with "La") | 37 |
| Region of Spain, with "La" | 36 |
| Region of the western United States | 35 |
| Region of unexplained disappearances | 36 |
| Region roughly the size of the United States | 44 |
| Region that includes parts of 10 U.S. states | 44 |
| Region west of the Strait of Belle Isle | 39 |
| Region where Riesling wines are made | 36 |
| Region whose capital is Florence | 32 |
| Region whose largest animal resident is the ibex | 48 |
| Region whose residents may have a long commute | 46 |
| Region with a particular weather | 32 |
| Regional air travel brand since 1984 | 36 |
| Regional judicial body that hears appeals: abbr. | 48 |
| Regional setting for almost eight months per yr. | 48 |
| Regions filled with small planets | 33 |
| Register for (with "in") | 34 |
| Register for, with "in": var. | 39 |
| Register key pressed when making change | 39 |
| Register one's dissatisfaction | 34 |
| Register, as for a course (Var.) | 32 |
| Registered one's arrival at work | 36 |
| Registered right to three rings? | 32 |
| Registering the most on the applause-o-meter | 44 |
| Registers for a meditation class? | 33 |
| Registration desk's locale, often | 37 |
| Regressive source of revenue, often | 35 |
| Regret losing some guy during long-winded speech? | 49 |
| Regrets a marsupial's trickery? | 35 |
| Regrettably, easily downloadable things | 39 |
| Regretting yesterday's activity, perhaps | 44 |
| Regular "Laugh-In" feature | 36 |
| Regular "What's My Line?" panelist | 48 |
| Regular at Kelsey's Bar, on TV | 34 |
| Regular character in "Blondie" | 40 |
| Regular girlfriend, in the '50s | 35 |
| Regular guy after a buffet dinner? | 34 |
| Regular Manhattan university transport? | 39 |
| Regular order (with ''the'') | 44 |
| Regular's order (with "the") | 42 |
| Regular's request, with "the" | 43 |
| Regularly paid financial allowance | 34 |
| Regularly, but not too frequently | 33 |
| Regulars, or what they'll have | 34 |
| Regulation targets for Theodore Roosevelt: Abbr. | 48 |
| Regulations against liquor sales, etc. | 38 |
| Regulations against Sunday drinking | 35 |
| Regulations against Sunday drinking, etc. | 41 |
| Regulations that govern lotteries, e.g. | 39 |
| Regulator of some traffic: Abbr. | 32 |
| Regulus' constellation, with "the" | 48 |
| Rehnquist's sign, appropriately | 35 |
| Rehnquist's successor on the high bench | 43 |
| Reich's "The ___ of America" | 42 |
| Reichenbach's electrical force | 34 |
| Reichenbach's hypnotic force | 32 |
| Reid of "American Pie" | 32 |
| Reid of "American Reunion" | 36 |
| Reid of "WKRP in Cincinnati" | 38 |
| Reid often read about in tabloids | 33 |
| Reid succeeded him as Senate minority leader | 44 |
| Reign between the Qin and the Three Kingdoms | 44 |
| Reign noted for magnificent porcelain | 37 |
| Reigned in a Foo Fighters single? | 33 |
| Reigning "Imperial Majesty" | 37 |
| Reigning champion's question to challengers | 47 |
| Reik's "The Secret ___" | 37 |
| Reincarnationists' existences | 33 |
| Reindeer caretakers, traditionally | 34 |
| Reindeer in Disney's "Frozen" | 43 |
| Reindeer landing strip, allegedly | 33 |
| Reiner of "All in the Family" | 39 |
| Reiner's "___ Laughing" | 37 |
| Reinforce, with ''up'' | 38 |
| Reinforced, as a coastline (with "up") | 48 |
| Reinstated athlete's position? | 34 |