| Second-century astronomer and mathematician | 43 |
| Second-commonest blood type: Abbr. | 34 |
| Second-generation Asian-American | 32 |
| Second-generation Japanese American | 35 |
| Second-generation Japanese in the U.S. | 38 |
| Second-generation Japanese-American | 35 |
| Second-generation Japanese/American | 35 |
| Second-generation senator from Indiana | 38 |
| Second-highest course concentration, often | 42 |
| Second-highest in four-part harmony | 35 |
| Second-highest mountain in the contiguous US | 44 |
| Second-highest mountain in the lower 48 states | 46 |
| Second-highest peak in the Cascades | 35 |
| Second-highest voice in a four-part chorus | 42 |
| Second-highest-grossing film of 2003 | 36 |
| Second-in-command in the kitchen | 32 |
| Second-in-command to Captain Kirk | 33 |
| Second-largest Arab emirate in area | 35 |
| Second-largest Central American city | 36 |
| Second-largest city in Kyrgyzstan | 33 |
| Second-largest city in New Hampshire | 36 |
| Second-largest city in Nicaragua | 32 |
| Second-largest city in the 46th state | 37 |
| Second-largest city of Rhode Island | 35 |
| Second-largest city on the Atlantic coast | 41 |
| Second-largest country in Africa by area | 40 |
| Second-largest denomination of Islam | 36 |
| Second-largest Islam denomination | 33 |
| Second-largest island in the Med. | 33 |
| Second-largest lake in North America | 36 |
| Second-largest land animal, briefly | 35 |
| Second-largest Mediterranean island | 35 |
| Second-largest moon in the solar system | 39 |
| Second-largest of the deer family | 33 |
| Second-largest of the Hawaiian islands | 38 |
| Second-largest planet in the solar system | 41 |
| Second-largest Sri Lankan ethnicity | 35 |
| Second-largest U.S. island in area | 34 |
| Second-largest U.S. stock exchange | 34 |
| Second-largest W. Hemisphere country in area | 44 |
| Second-least populous st. capital | 33 |
| Second-most populous Arizona city | 33 |
| Second-most populous nation in Afr. | 35 |
| Second-most populous of the United Arab Emirates | 48 |
| Second-most-massive dwarf planet | 32 |
| Second-oldest country in the Western Hemisphere | 47 |
| Second-oldest General Mills cereal | 34 |
| Second-oldest member of the Jackson 5 | 37 |
| Second-person singular of ''be'' | 48 |
| Second-place finisher's triumph | 35 |
| Second-rate singer's residence | 34 |
| Second-rate untouched grounds (5) | 33 |
| Second-stringer with a good attitude? | 37 |
| Second-to-last letter of the Greek alphabet | 43 |
| Second-to-last word of many fairy tales | 39 |
| Second-year collegians, for short | 33 |
| Second-year collegians, informally | 34 |
| Second-youngest March sister, in literature | 43 |
| Secondary character in Aristophanes? | 36 |
| Secondary landscape object, perhaps | 35 |
| Secondary seascape object, perhaps | 34 |
| Seconds, of a sort, for a ruminant | 34 |
| Secret agent created by a 1938 Pulitzer winner | 46 |
| Secret agent created by John P. Marquand | 40 |
| Secret agent disguised as a clergyman? | 38 |
| Secret agent TV show of the '60s | 36 |
| Secret Chinese society, in the U.S. | 35 |
| Secret dish in "Sweeney Todd" | 39 |
| Secret entrances under carpets, perhaps | 39 |
| Secret formula for making fasteners? | 36 |
| Secret of Glen Bell's success | 33 |
| Secret police before the wall fell | 34 |
| Secret police who fell with the Berlin Wall | 43 |
| Secret Service agent's accessory, at times | 46 |
| Secret Service agent's accouterment | 39 |
| Secret Service agent's weapon | 33 |
| Secret Service agent, until recently | 36 |
| Secret Service's charge: Abbr. | 34 |
| Secret society member, perhaps, briefly | 39 |
| Secret the theme answers contain | 32 |
| Secret weapons of riverboat gamblers | 36 |
| Secret Wish Magic Romance perfume creator | 41 |
| Secret ___ (seasonal office game) | 33 |
| Secret-agent TV show of the '60s | 36 |
| Secretariat's autobiography? | 32 |
| Secretariat's post-racing role | 34 |
| Secretariat's retirement role | 33 |
| Secretariat's role in retirement | 36 |
| Secretaries may collect them: Abbr. | 35 |
| Secretaries of State and Defense | 32 |
| Secretary between Herter and Rogers | 35 |
| Secretary General before Kurt Waldheim | 38 |
| Secretary General Javier Pérez ___ | 37 |
| Secretary of Agriculture (civil rights leader) | 46 |
| Secretary of Agriculture under Clinton | 38 |
| Secretary of Commerce: 1969–72 | 37 |
| Secretary of Defense after Cheney | 33 |
| Secretary of Defense: 1969–72 | 36 |
| Secretary of Defense: 1969–73 | 36 |
| Secretary of Interior: 1961–69 | 37 |