| An enzyme | 9 |
| An EPA concern | 14 |
| An epic clout? | 14 |
| An epicure has a refined one | 28 |
| An epithet of Juno | 18 |
| An equal | 8 |
| An equal number of | 18 |
| An equal share, say | 19 |
| An equilateral parallelogram | 28 |
| An equine color | 15 |
| An ergosphere surrounds it | 26 |
| An Eskimo roll might right one | 30 |
| An essay may be on one | 22 |
| An essayist's pen name | 26 |
| An essayist's work is in it | 31 |
| An essential amino acid | 23 |
| An essential element | 20 |
| An essential ingredient | 23 |
| An essential vitamin | 20 |
| An established custom | 21 |
| An ester used in ointments | 26 |
| An estuary of the Amazon | 24 |
| An eternity | 11 |
| An eternity, seemingly | 22 |
| An Evangelist | 13 |
| An evangelist's first name | 30 |
| An evasive dance before Thanksgiving? | 37 |
| An Eve | 6 |
| An evening in Florence | 22 |
| An evening of TV viewing, e.g. | 30 |
| An evening party | 16 |
| An event to honor the best hospital patient? | 44 |
| An event won by Jesse Owen | 26 |
| An evergreeen | 13 |
| An evergreen | 12 |
| An evil soul's sin? (Anagram) | 33 |
| An evil spirit | 14 |
| An ex of Artie | 14 |
| An ex of Artie and Frank | 24 |
| An ex of Artie, Mickey and Frank | 32 |
| An ex of Ava | 12 |
| An ex of Burt | 13 |
| An ex of Frank | 14 |
| An ex of Marilyn | 16 |
| An ex of Mickey | 15 |
| An ex of Sinatra | 16 |
| An ex of the Donald | 19 |
| An ex of Xavier | 15 |
| An ex-screen star drops an ex-Cub star | 38 |
| An ex-Trump | 11 |
| An exam | 7 |
| An example | 10 |
| An example of change in Russia | 30 |
| An example of Emeril's largesse? | 36 |
| An example would be "Take my wife, please!" | 53 |
| An excess of | 12 |
| An exciting moment on Dec. 31 | 29 |
| An excuse | 9 |
| An exec may have one | 20 |
| An exemplar of neatness | 23 |
| An exercise for Rubinstein | 26 |
| An exiled Yank, perhaps | 23 |
| An exorbitant amount | 20 |
| An expat may take it: Abbr. | 27 |
| An expectant father, e.g. | 25 |
| An expense homeowners don't have | 36 |
| An expert in gods | 17 |
| An expert might sit on one | 26 |
| An expert on E. O'Neill | 27 |
| An expletive | 12 |
| An explosive | 12 |
| An explosive, for short | 23 |
| An explosive: Abbr. | 19 |
| An express might pass one: Abbr. | 32 |
| An expression of disdain | 24 |
| An expression of regret | 23 |
| An extra pair | 13 |
| An extremely long period of time | 32 |
| An extremely long time | 22 |
| An extremity | 12 |
| An eye for an eye to some? | 27 |
| An eye for an eye, but also... | 30 |
| An eye for poetry? | 18 |
| An eye for the poetic? | 22 |
| An eye opener | 13 |
| An eye, ear or nose, e.g. | 25 |
| An F.D.R. measure | 17 |
| An F.D.R. V.P. | 14 |
| An F.D.R./Stalin meeting place | 30 |
| An H.S. dropout may earn one | 28 |
| An honest man | 13 |
| An hors d'oeuvre | 20 |
| An hour after midnight | 22 |
| An hour after noon | 18 |
| An hour before midnight | 23 |
| An hour before noon | 19 |
| An hour in Roma | 15 |
| An hour of prime-time TV, often | 31 |
| An hour's worth of tunes, maybe | 35 |
| An hourglass may set it | 23 |