| Islands west of Key West | 24 |
| Islands west of Portugal | 24 |
| Islands with giant tortoises | 28 |
| Islands: "The ___" | 28 |
| Isle and city in E England | 26 |
| Isle famed for oil refining | 27 |
| Isle identified with Napoleon | 29 |
| Isle in famous a palindrome | 27 |
| Isle in the Bay of Naples | 25 |
| Isle near St. Christopher | 25 |
| Isle not far from Naples | 24 |
| Isle of Arthurian legend | 24 |
| Isle of Capri attraction | 24 |
| Isle of exile for Napoleon | 26 |
| Isle of Man's locale | 24 |
| Isle of Man's waterfront | 28 |
| Isle of Napoleon's exile | 28 |
| Isle of the Inner Hebrides | 26 |
| Isle of Wight location | 22 |
| Isle of Wight settlers | 22 |
| Isle of ___ (English county) | 28 |
| Isle of ___, in England | 23 |
| Isle of ___, in the Irish Sea | 29 |
| Isle of _____, England | 22 |
| Isle off coast of Ireland | 25 |
| Isle off New Caledonia | 22 |
| Isle off the lower boot | 23 |
| Isle on the Gulf of Naples | 26 |
| Isle on which Apollo was born | 29 |
| Isle ruled by Morgan le Fay | 27 |
| Isle used as a base by Xerxes | 29 |
| Isle where Macbeth is buried | 28 |
| Isle where Saint Columba died | 29 |
| Isle ___ (site off England) | 27 |
| Isle ___ National Park | 22 |
| Isles in Malay Archipelago | 26 |
| Islet in a British river | 24 |
| Islets of Langerhans locale | 27 |
| Isley Brothers classic | 22 |
| Isn't on the street | 24 |
| Isn't a benchwarmer | 23 |
| Isn't a natural blonde | 26 |
| Isn't all the same | 22 |
| Isn't an odd one out | 24 |
| Isn't complete without | 26 |
| Isn't delicate with | 23 |
| Isn't doing support work | 28 |
| Isn't exactly opportune | 27 |
| Isn't far from reaching | 27 |
| Isn't feeling good | 22 |
| Isn't feeling up to snuff | 29 |
| Isn't feeling well | 22 |
| Isn't for couples? | 22 |
| Isn't for more than one | 27 |
| Isn't for some people? | 26 |
| Isn't for the uneducated? | 29 |
| Isn't free and clear | 24 |
| Isn't fully upright | 23 |
| Isn't fully vertical | 24 |
| Isn't getting any younger | 29 |
| Isn't going anywhere | 24 |
| Isn't in a big hurry | 24 |
| Isn't in the black | 22 |
| Isn't in the clear? | 23 |
| Isn't just a benchwarmer | 28 |
| Isn't just a licensee | 25 |
| Isn't just guessing | 23 |
| Isn't just theoretical | 26 |
| Isn't likely to succeed | 27 |
| Isn't Nicklaus a card? | 26 |
| Isn't on the fence | 22 |
| Isn't on the level | 22 |
| Isn't on the level? | 23 |
| Isn't on the street? | 24 |
| Isn't out of the running | 28 |
| Isn't perpendicular | 23 |
| Isn't polite with soup | 26 |
| Isn't pressed, in a way | 27 |
| Isn't quite neutral | 23 |
| Isn't quite perpendicular | 29 |
| Isn't quite ready to blow | 29 |
| Isn't quite vertical | 24 |
| Isn't really right | 22 |
| Isn't recalcitrant | 22 |
| Isn't self-contained | 24 |
| Isn't serious about | 23 |
| Isn't shy with an opinion | 29 |
| Isn't straight up with | 26 |
| Isn't straight with | 23 |
| Isn't strict enough, say | 28 |
| Isn't supporting on stage | 29 |
| Isn't that just perfect? | 28 |
| Isn't the wrong way | 23 |
| Isn't uncorrected? | 22 |
| Isn't very visible | 22 |
| Isn't, alternatively | 24 |
| Isn't, nonstandardly | 24 |
| Isn't, the wrong way | 24 |
| Isolate again, as a beat | 24 |
| Isolate during the winter | 25 |