| Popular relief for painful pectorals | 36 |
| Popular restaurant chain, briefly | 33 |
| Popular restaurant chain, familiarly | 36 |
| Popular restaurant chain, for short | 35 |
| Popular retirement city, informally | 35 |
| Popular roadside chain, for short | 33 |
| Popular Russian import, informally | 34 |
| Popular Russian vodka, familiarly | 33 |
| Popular sandwich for kids, for short | 36 |
| Popular science fiction magazine | 32 |
| Popular shopping place these days | 33 |
| Popular singer born in County Donegal | 37 |
| Popular singing show, familiarly | 32 |
| Popular six-second clips since 2013 | 35 |
| Popular song of the '30's | 33 |
| Popular source of quotes, for short | 35 |
| Popular South African language group | 36 |
| Popular spot for kids' houses | 33 |
| Popular St. Valentine's Day gift | 36 |
| Popular Star Trek convention costume | 36 |
| Popular subjects in Renaissance art | 35 |
| Popular Sunshine State vacation destination | 43 |
| Popular teen hangout 50+ years ago | 34 |
| Popular telecommunications device | 33 |
| Popular test animal in medical research | 39 |
| Popular tourist destination of Southeast Asia | 45 |
| Popular tourist spot in western Wyoming | 39 |
| Popular tune for tenor or accordion | 35 |
| Popular TV drama of the '80s | 32 |
| Popular TV drama set in Las Vegas | 33 |
| Popular TV personality (11/20/1932-6/2/2012) | 44 |
| Popular U.S. board game since 1959 | 34 |
| Popular Upper East Side restaurant until 2011 | 45 |
| Popular vacation spot, with "the" | 43 |
| Popular Valentine's Day gift | 32 |
| Popular Valentine's Day items | 33 |
| Popular video game franchise since 2001 | 39 |
| Popular video game of the late 1990s | 36 |
| Popular video game series discontinued in 2011 | 46 |
| Popular way to get around New York City | 39 |
| Popular wedding-cake decorations | 32 |
| Popular whale-watching destination | 34 |
| Popular winter flower in the South | 34 |
| Popular word in German product packaging | 40 |
| Popularity boost due to a certain TV endorsement | 48 |
| Popularizer of "Mule Train" | 37 |
| Population of interest to ornithologists | 40 |
| Population of Strong Badia, on homestarrunner.com | 49 |
| Populist power couple of the 1940s-'50s | 43 |
| Por ___ (for example, in Spanish) | 33 |
| Porcelain-like material used in vases | 37 |
| Porcelainlike material used in vases | 36 |
| Porch on "The Golden Girls" | 37 |
| Porch where succulent plants are grown? | 39 |
| Porcine actress in "A Mighty Wind"? | 45 |
| Porcine comedian who portrayed Jiminy Glick? | 44 |
| Porcine comic who once had her own sitcom? | 42 |
| Porcine constructors, with "The" | 42 |
| Porcine ice skating gold medalist? | 34 |
| Porcupine army's attack command? | 36 |
| Porcupine's quill, for example | 34 |
| Porfirio ___, president of Mexico, 1884-1911 | 44 |
| Pork product used in southern cooking | 37 |
| Pork ___ (source of Canadian bacon) | 35 |
| Porky and Buckwheat's "Sure!" | 43 |
| Porky Pig's home movie presentation? | 40 |
| Porky's penultimate parting word | 36 |
| Porn magazine with a French title | 33 |
| Porn mogul standing next to an X-Man? | 37 |
| Porno for Pyros "Cursed ___" | 38 |
| Pornstar Danielle with 32FF-sized breasts | 41 |
| Porsche-designed monster tank of WWII | 37 |
| Port 'twixt Buffalo and Cleveland | 37 |
| Port au Basque to Bonav-ista Twillingate dir. | 45 |
| Port between Algiers and Tangier | 32 |
| Port between Buffalo and Cleveland | 34 |
| Port between Tangier and Algiers | 32 |
| Port called the Cinderella of the Pacific | 41 |
| Port capital of Hyogo Prefecture | 32 |
| Port captured by Allied forces in 1942 | 38 |
| Port captured by Napoleon in 1799 | 33 |
| Port city built around an old volcano crater | 44 |
| Port city from which Amelia Earhart last flew | 45 |
| Port city in "Casablanca" | 35 |
| Port city in Japan on Osaka Bay | 34 |
| Port city on an arm of the Black Sea | 36 |
| Port city or the lake it's on | 33 |
| Port five miles from the Blarney Stone | 38 |
| Port for a "desert ship" | 34 |
| Port in "The Marines' Hymn" | 41 |
| Port in Scott's "Lord of the Isles" | 49 |
| Port in the eastern Mediterranean | 33 |
| Port in the Ille-et-Vilaine department | 38 |
| Port named after a U.S. president, informally | 45 |
| Port named for a Scandinavian god | 33 |
| Port of Crete that was once its capital | 39 |
| Port of importance in the Crusades | 34 |
| Port on Italy's "heel" | 36 |
| Port on the eastern Mediterranean | 33 |
| Port seized by the Crusaders, 1191 | 34 |