| First major league manager to have 2000 wins and have 2000 hits | 63 |
| First major party female nominee for U.S. vice president | 56 |
| First major U.S. medical school to admit women as well as men | 61 |
| First male on the cover of ''Vogue'' | 52 |
| First man featured on the cover of the U.S. edition of Vogue | 60 |
| First man to win the French Open without dropping a set | 55 |
| First mass-produced American car with pop-up headlights | 55 |
| First multiracial coeducational college in the South | 52 |
| First music video inducted into the National Film Registry | 58 |
| First musical artist to have a #1 album while imprisoned | 56 |
| First N.F.L. player to record 100 receptions in a season | 56 |
| First N.F.L. QB with consecutive 30-touchdown passing seasons | 61 |
| First N.H.L. player to score over 70 goals in a season | 54 |
| First name alphabetically in the Baseball Hall of Fame | 54 |
| First name among ''American Idol'' judges | 57 |
| First name among "The Beverly Hillbillies" cast | 57 |
| First name among "The Simpsons" characters | 52 |
| First name among former ''SNL'' cast members | 60 |
| First name among the ''30 Rock'' cast | 53 |
| First name among the ''American Idol'' judges | 61 |
| First name among the ''Baywatch'' cast | 54 |
| First name among the ''Cheers'' cast | 52 |
| First name among the ''Desperate Housewives'' cast | 66 |
| First name among the ''Friends'' cast | 53 |
| First name among the ''Happy Days'' cast | 56 |
| First name among the ''Hee Haw'' cast | 53 |
| First name among the ''Kill Bill'' cast | 55 |
| First name among the ''Paper Moon'' cast | 56 |
| First name among the ''The Sopranos'' cast | 58 |
| First name among the cast of ''The Graduate'' | 61 |
| First name in ''The Cocoanuts'' cast | 52 |
| First name in ''The Ten Commandments'' cast | 59 |
| First name in ''Who's Who in the Bible'' | 60 |
| First name in "Who's Who in the Bible" | 52 |
| First name in supermodeling, or the magazine that bears her name | 64 |
| First name in the ''All About Eve'' cast | 56 |
| First name in the ''Barney Miller'' cast | 56 |
| First name in the ''Beverly Hills, 90210'' cast | 63 |
| First name in the ''Desperate Housewives'' cast | 63 |
| First name in the ''Doctor Zhivago'' cast | 57 |
| First name in the ''Ocean's Twelve'' cast | 61 |
| First name in the ''Pleasantville'' cast | 56 |
| First name in the ''Pulp Fiction'' cast | 55 |
| First name in the ''Sister Act'' cast | 53 |
| First name in the ''Star Wars'' cast | 52 |
| First name in the "Desperate Housewives" cast | 55 |
| First name in the "Ocean's Thirteen" cast | 55 |
| First name of ''Catwoman'''s star | 53 |
| First name of ''Lestat'''s composer | 55 |
| First name of ''The Texas Troubadour'' | 54 |
| First name of "The King of the High C's" | 54 |
| First name of a ''The Color Purple'' cast member | 64 |
| First name of a "Desperate Housewives" star | 53 |
| First name of Billy Crystal's character on "Soap" | 63 |
| First name of country star Tritt or last name of country star Randy | 67 |
| First name of Football Hall of Famer Crazylegs Hirsch | 53 |
| First name of literature's "Weaver of Raveloe" | 60 |
| First name of Sports Illustrated's 1988 Sportsman of the Year | 65 |
| First name of the #1 player when ATP rankings started in 1973 | 61 |
| First name of the ''Contract with America'' architect | 69 |
| First name of the "Father of Classical Guitar" | 56 |
| First name of the "Goodbye, Columbus" novelist | 56 |
| First name of the creator of Veruca Salt and Augustus Gloop | 59 |
| First name of the first chairman of the Joint Chiefs of Staff | 61 |
| First name of the first female Supreme Court justice | 52 |
| First name of the pitcher nicknamed "Bulldog" | 55 |
| First name of the swimmer dubbed the "Thorpedo" | 57 |
| First name of the title character in "Doonesbury" | 59 |
| First name of the wolf in Disney's "The Big Bad Wolf" | 67 |
| First name on "America's Next Top Model" | 54 |
| First name on the album "Voice of the Xtabay" | 55 |
| First name that's feminine in English and masculine in Italian | 66 |
| First National Leaguer with eight consecutive 100-R.B.I. seasons | 64 |
| First National Leaguer with eight consecutive 100-RBI seasons | 61 |
| First Negro Leaguer inducted into the Baseball Hall of Fame | 59 |
| First newspaper to send war correspondents, with "The" | 64 |
| First NFL quarterback to pass for 5,000 yards in one season | 59 |
| First novel in Cather's "prairie trilogy" | 55 |
| First novel in Christopher Paolini's Inheritance Cycle | 58 |
| First of two groups that may come in handy for this puzzle? | 59 |
| First ones to spot the king's ghost, in "Hamlet" | 62 |
| First opera to premiere at London's Savoy Theatre, 1882 | 59 |
| First Oscar recipient for a non-English-speaking role | 53 |
| First over-all NFL draft pick between Carson and Alex | 53 |
| First part of a Mark Twain quote "The ---" | 52 |
| First part of a riddle, following "What is ...?" | 58 |
| First part of an incomplete stepquote by Rudyard Kipling | 56 |
| First part of Miller's "The Rosy Crucifixion" | 59 |
| First person outside NASA to receive a moon-rock award, 2006 | 60 |
| First person to reach the geographic North Pole, he claimed | 59 |
| First pilot to travel faster than the speed of sound | 52 |
| First pitcher to have defeated all 30 major-league teams | 56 |
| First place mentioned in the Beach Boys' "Kokomo" | 63 |
| First player to win the Hart Trophy three times in a row | 56 |
| First pope to have visited Constantinople while in office | 57 |
| First preposition preceding "pursuit of Happiness" | 60 |
| First president born outside the original 13 colonies | 53 |
| First president buried at Arlington National Cemetery | 53 |
| First president to have a telephone in the White House | 54 |
| First president to throw a ceremonial opening day pitch | 55 |