| 2000 film about a mission to Mars | 33 |
| 2000 essay collection by David Sedaris | 38 |
| 2000 Elton John/Tim Rice musical | 32 |
| 2000 election's point of contention | 39 |
| 2000 Disney movie starring Bruce Willis | 39 |
| 2000 Democratic campaign slogan? | 32 |
| 2000 comedy "Me, Myself & ___" | 44 |
| 2000 Cadbury Schweppes acquisition | 34 |
| 2000 Broadway show featuring music by Elton John | 48 |
| 2000 biopic about James Joyce's love | 40 |
| 2000 best seller on social epidemics | 36 |
| 2000 Best Original Screenplay nominee | 37 |
| 2000 Best New Artist Grammy winner ___ Lynne | 44 |
| 2000 Best New Artist Grammy winner | 34 |
| 2000 Best Foreign Language Film nominee | 39 |
| 2000 Best Costume Design nominee | 32 |
| 2000 Beatles album or its peak chart position | 45 |
| 2000 “mockumentary” about dogs | 38 |
| 2000 and 2004 swimming gold medalist Ian | 40 |
| 2000 All-Star Game and World Series MVP | 39 |
| 2000 "subway series" losers | 37 |
| 2000 #1 hit by Destiny's Child | 34 |
| 20's tennis champion Lacoste | 32 |
| 20's hit "___ Get By" | 35 |
| 20's "All American" | 33 |
| 20 ... (when completed, a military salvo) | 41 |
| 2-in-1 shampoo-conditioner since 1987 | 37 |
| 2,240 pounds (with ''long'') | 44 |
| 2,100-square mile island with six volcanoes | 43 |
| 2,000 pounds of a Chinese soup = | 32 |
| 2, 3 or 4, usually, in miniature golf | 37 |
| 2 P.M.: "Heinous Crime" | 33 |
| 2 or 3, maybe, on the Richter scale | 35 |
| 2 or 3 or 5, e.g. (after using a pull down menu) | 48 |
| 2 or 3 on the Richter scale, maybe | 34 |
| 2 Live Crew "___ in the USA" | 38 |
| 2 Live Crew "___ Horny" | 33 |
| 2 Live Crew "Banned in the ___" | 41 |
| 2 letters + have no doubt + show reverence = ? | 46 |
| 1st to 220th, in Manhattan: Abbr. | 33 |
| 1st Atlantic album by Rush in '89 | 37 |
| 19th/20th-century civil rights leader __ B. Wells | 49 |
| 19th-century writer Sarah ___ Jewett | 36 |
| 19th-century women's rights advocate | 40 |
| 19th-century violinist/composer Louis | 37 |
| 19th-century urban transportation | 33 |
| 19th-century territorial capital | 32 |
| 19th-century Swedish writer Esaias ___ | 38 |
| 19th-century social reformer ___ Coffin Mott | 44 |
| 19th-century Shakespearean actor Edmund | 39 |
| 19th-century queen's tough tests? | 37 |
| 19th-century presidential nickname | 34 |
| 19th-century presidential middle name | 37 |
| 19th-century nun from Lisieux, France | 37 |
| 19th-century novelist with an appropriate name | 46 |
| 19th-century novel set on Tahiti | 32 |
| 19th-century Norwegian mathematician Abel | 41 |
| 19th-century Mexican president Juárez | 40 |
| 19th-century mail delivery service | 34 |
| 19th-century London Magazine essayist | 37 |
| 19th-century literary family name | 33 |
| 19th-century literary family in Massachusetts | 45 |
| 19th-century landscape painter George | 37 |
| 19th-century king of Sweden and Norway | 38 |
| 19th-century journalist/politician ___ Kendall | 46 |
| 19th-century Italian violin virtuoso | 36 |
| 19th-century industrialist Lilly | 32 |
| 19th-century hero of Italian unification | 40 |
| 19th-century Harper's Weekly cartoonist | 43 |
| 19th-century German poet Heinrich | 33 |
| 19th-century fur trade monopolist | 33 |
| 19th-century French book illustrator | 36 |
| 19th-century essayist wielding a vacuum? | 40 |
| 19th-century English philosopher and economist | 46 |
| 19th-century English novelist Charles | 37 |
| 19th-century conductor Hans von -- | 34 |
| 19th-century British prime minister | 35 |
| 19th-century British geologist Sir Charles __ | 45 |
| 19th-century Austrian composer of nine symphonies | 49 |
| 19th-century African-American congressman Joseph | 48 |
| 19th-century abbot and scientist | 32 |
| 19th-/20th-century U.S. portraitist | 35 |
| 19th letter of the Greek alphabet | 33 |
| 19th letter of Greek alphabet: pl. | 34 |
| 19th century writer of inspiring novels | 39 |
| 19th century tale of South Seas travel | 38 |
| 19th century political cartoonist Thomas | 40 |
| 19th century communications pioneer | 35 |
| 19th century Chief Justice Roger ___ | 36 |
| 19th C. art style emphasizing nature | 36 |
| 1999-2001 Broadway musical revue | 32 |
| 1999-2000 "Dame" on Broadway | 38 |
| 1999 World Series runner-up: Abbr. | 34 |
| 1999 U.S. Ryder Cup team captain | 32 |
| 1999 Top 10 hit for Sixpence None the Richer | 44 |
| 1999 Tom Hanks film, with "The" | 41 |
| 1999 Tim Allen/Sigourney Weaver cult comedy | 43 |
| 1999 teammate of Brandi, Briana, et al. | 39 |
| 1999 teammate of Brandi, Briana et al. | 38 |
| 1999 Stanley Cup finals competitor | 34 |