| Initials of Dr. Jekyll's creator | 36 |
| Initials of Jekyll's creator | 32 |
| Initials of Jim Hawkins's creator | 37 |
| Initials of Mr. Hyde's creator | 34 |
| Initials of the Wagner Act: 1935 | 32 |
| Initials often jokingly redefined on T-shirts | 45 |
| Initials on a Cardinal's cap | 32 |
| Initials on a dentist's diploma | 35 |
| Initials on a U.S.S.R. player's jersey | 42 |
| Initials on L'Homme fragrance | 33 |
| Initials on some toothpaste tubes | 33 |
| Initials on the cover of "The Hobbit" | 47 |
| Initials on the New Jersey, e.g. | 32 |
| Initials seen at a checkout counter | 35 |
| Initiates withdrawals of defective products? | 44 |
| Inits. for an armchair quarterback? | 35 |
| Inits. for Judith Anderson, e.g. | 32 |
| Inits. for Kate Middleton, someday | 34 |
| Inits. for Lowe's or Home Depot shoppers | 44 |
| Inits. in '70s and '80s rock | 36 |
| Inits. in 70's-80's rock | 32 |
| Inits. indicating unfinished business | 37 |
| Inits. of a noted "Wizard" | 36 |
| Inits. of an ill-fated ex-Playmate | 34 |
| Inits. of Ben Gunn's creator | 32 |
| Inits. of William and Kate's royal baby | 43 |
| Inits. on a bottle of Parisienne | 32 |
| Inits. on a princess's towels? | 34 |
| Inits. on many uniforms since 2002 | 34 |
| Inits. on most Rolling Stones records | 37 |
| Injured "Matrix" character? | 37 |
| Injured again, as a rotator cuff | 32 |
| Injured baseball players go on them: abbr. | 42 |
| Injured basketball player's preoccupation? | 46 |
| Injured center yearned to resume play? | 38 |
| Injuries sustained at the O.K. Corral, say | 42 |
| Injury around a horse's hoof | 32 |
| Injury found in this grid's upper-left corner | 49 |
| Injury requiring emergency room treatment | 41 |
| Injury rosters, in baseball: abbr. | 34 |
| Injury sometimes caused by an arsonist | 38 |
| Injury sustained before the semis? | 34 |
| Injustice for "The Fugitive" | 38 |
| Ink-lined plane used by lottery commission? | 43 |
| Inlaid furniture decoration (Var.) | 34 |
| Inland duty on commodities: Abbr. | 33 |
| Inland sea on the Kazakhstan border | 35 |
| Inland sea that crosses the border of Uzbekistan | 48 |
| Inland sea whose name means "island" | 46 |
| Inlay style using a mosaic of wood pieces | 41 |
| Inlet of the Coral Sea: Gulf of ____ | 36 |
| Inmate who's never getting out | 34 |
| Inn that doesn't get many guests? | 37 |
| Inner circle (with "the") | 35 |
| Inner circles, in astronomy models | 34 |
| Inner Party member in "1984" | 38 |
| Inner self, in Jungian psychology | 33 |
| Inner walls of fortification ditches | 36 |
| Innermost of Saturn's five major moons | 42 |
| Inning-ending plays, often: Abbr. | 33 |
| Innocent dreams may originate here | 34 |
| Innovation in the 1962 Buick Special | 36 |
| Innovation of the Paleolithic period | 36 |
| Innovation that improved fuel economy | 37 |
| Innovative Broadway producer: 1871–1937 | 46 |
| Innovative chair designer Aarnio | 32 |
| Innovative Chicago football coach | 33 |
| Innovative furniture designer Aarnio | 36 |
| Input for a personnel interviewer | 33 |
| Inquire about, as someone's health | 38 |
| Inquire into relatives' secrets? | 36 |
| Inquiry made while half awake, maybe | 36 |
| Inquiry sent out at the P.O. re a lost letter | 45 |
| Inquisitive 2010 Ringo Starr album? | 35 |
| Inquisitive communications slogan | 33 |
| Inquisitor whose name now means persecutor | 42 |
| Ins. underwriter's credential | 34 |
| Inscription at the end of a book | 32 |
| Inscription of Caesar's time | 32 |
| Inscription on a Wonderland cake | 32 |
| Inscription on stained glass, maybe | 35 |
| Insect bite consequence, perhaps | 32 |
| Insect called a greenfly in Britain | 35 |
| Insect collector's subject (abbr.) | 38 |
| Insect found near ponds or lakes | 32 |
| Insect honored on a 1999 U.S. postage stamp | 43 |
| Insect in "High Hopes" | 32 |
| Insect in the order Siphonaptera | 32 |
| Insect interpreting sacred mysteries? | 37 |
| Insect known for conducting raids | 33 |
| Insect named for the Virgin Mary | 32 |
| Insect sung about in "High Hopes" | 43 |
| Insect swarm's dental problem? | 34 |
| Insect that bit Sleeping Beauty? | 32 |
| Insect that can control the sex of its offspring | 48 |
| Insect that causes sleeping sickness | 36 |
| Insect that may be covered in chocolate | 39 |
| Insect that will take it all back | 33 |
| Insect that's 'praying' | 35 |
| Insect that's an agent to celebrities? | 42 |