| Eponymous 1850s-'70s Mexican president | 42 |
| Eponym of the world's fifth-largest island | 46 |
| Eponym of the trophy for the NFC champion | 41 |
| Eponym of the New York City mayor's mansion | 47 |
| Eponym of the city now known as Istanbul | 40 |
| Eponym of an Australian Open arena | 34 |
| Eponym of an annual Norwegian math prize | 40 |
| Eponym of a Tanglewood concert hall | 35 |
| Eponym of a Southern "-ville" | 39 |
| Eponym of a physics lab near Chicago | 36 |
| Eponym of a Parkinson research center in Phoenix | 48 |
| Eponym of a North Carolina "-ville" | 45 |
| Eponym of a naturalists' society | 36 |
| Eponym of a national forest in New Mexico | 41 |
| Eponym of a major Canadian river | 32 |
| Eponym of a Flushing Meadows tennis stadium | 43 |
| Eponym of a Flushing Meadows stadium | 36 |
| Eponym of a classic Minnesota-brewed beer | 41 |
| Eponym of a Carnegie Hall auditorium | 36 |
| Eponym for an annual literary award since 1919 | 46 |
| Eponym for a Plaza Hotel tea service for kids | 45 |
| Eponym for a campus building, often | 35 |
| Eponym for a Batavia, IL particle physics lab | 45 |
| Epoch when modern mammals appeared | 34 |
| Epoch that saw the dawn of modern mammals | 41 |
| Epoch that saw the advent of mammals | 36 |
| Epoch of mammals' appearance | 32 |
| Epoch in which modern mammals first emerged | 43 |
| Epoch in which modern mammals emerged | 37 |
| Epoch in which mammals became dominant | 38 |
| Epoch in which grazing mammals became widespread | 48 |
| Epoch from two to five million years ago | 40 |
| Epoch from 10 to 2 million years ago | 36 |
| Epoch characterized by widespread glacial ice | 45 |
| Epoch characterized by the rise of mammals | 42 |
| Epoch between Paleocene and Oligocene | 37 |
| Epitomes of obvious differentness | 33 |
| Epitome of dedication, in modern usage | 38 |
| Epitome of cool, with "the" | 37 |
| Epithet of the mother of Romulus and Remus | 42 |
| Epithet of RodrigoDiaz de Vivar | 32 |
| Epithet never actually used by Cagney | 37 |
| Epithet for wife of Philip II of Spain | 38 |
| Epithet for the mouse in "To a Mouse" | 47 |
| Epithet for some Hollywood blondes | 34 |
| Epithet for President Bush, with "the" | 48 |
| Epithet for Pitt, Gladstone or Clay | 35 |
| Epithet for New York City's firefighters | 44 |
| Epithet for Napoleon, with "the" | 42 |
| Epithet for many leaders, with "the" | 46 |
| Epithet for John, with "the" | 38 |
| Epithet for business magnate Hughes? | 36 |
| Epithet for an annoying roommate | 32 |
| Epithet for an "American Idol" loser? | 47 |
| Epithet for a daughter of Henry VIII | 36 |
| Epithet for a 1914–1918 event | 36 |
| Epitaph holder ... or Mick Jagger? | 34 |
| Epitaph Dorothy Parker suggested for herself | 44 |
| Epistemological principle, familiarly | 37 |
| Episodes that may lead to more episodes | 39 |
| Episode of "The Brady Bunch," e.g. | 44 |
| Episcopal priest in charge of a chapel | 38 |
| Epicurus and Democritus, philosophically | 40 |
| Epic work with a “kleos” (glory) theme | 46 |
| Epic with more than 15,000 lines | 32 |
| Epic translated by Alexander Pope | 33 |
| Epic that tells of the Trojan horse | 35 |
| Epic that includes the Teichoscopia | 35 |
| Epic that ends with Hector's funeral | 40 |
| Epic tale that begins with the flight from Troy | 47 |
| Epic tale of Scottish patriot William Wallace | 45 |
| Epic poems adapted for recitation | 33 |
| Epic poem with about 16,000 lines | 33 |
| Epic poem by William Carlos Williams | 36 |
| Epic involving Achilles' wrath | 34 |
| Epic featuring the Catalogue of Ships | 37 |
| Epic Chinese author ___ Guanzhong | 33 |
| Epic blank-verse sequel by John Milton | 38 |
| Epic about Achilles, Hector et al. | 34 |
| Ephron/Kerouac book about rest stop fast food? | 46 |
| Ephron, perhaps, were she a colleen | 35 |
| Ephesians' place in the New Testament | 41 |
| Ephemeral keepsake from a vacation, perhaps | 43 |
| Epcot's "giant golf ball" | 39 |
| EPA pollutant concentration meas. | 33 |
| EPA measure of concern to asthma sufferers | 42 |
| Eoarchean and Neoarchean are two | 32 |
| Enzyme that breaks down genetic material | 40 |
| Enzyme regulating blood fluid and pressure | 42 |
| Environmentally-friendly vehicle | 32 |
| Environmentally-friendly energy source | 38 |
| Environmentally-destructive pesticide | 37 |
| Environmentally sensitive vacation choice | 41 |
| Environmentally minded, for short | 33 |
| Environmentally irresponsible off-roader | 40 |
| Environmentally friendly vehicle | 32 |
| Environmentally friendly Seuss character | 40 |
| Environmentally friendly birthday greeting | 42 |
| Environmentally destructive pesticide | 37 |
| Environmentalists' club name | 32 |