| Opening number of "Hair" | 34 |
| Opening of "A Tale of Two Cities" | 43 |
| Opening of a fuel-burning engine | 32 |
| Opening of a letter to a Baltic capital | 39 |
| Opening of a memorable walrus song | 34 |
| Opening of a sewage-filled pool? | 32 |
| Opening on an environmentalist's agenda? | 44 |
| Opening performance that steals the show, say | 45 |
| Opening routine, when the game is on ice | 40 |
| Opening screen option on many an A.T.M. | 39 |
| Opening to an underground network | 33 |
| Opening used before opening a door | 34 |
| Opening with dexterity or valence | 33 |
| Opening word of "Jabberwocky" | 39 |
| Opening word of "Send in the Clowns" | 46 |
| Opening word of "The Banana Boat Song" | 48 |
| Opening word of "The Waste Land" | 42 |
| Opening word of “Richard III” | 37 |
| Opening word of many an Italian letter | 38 |
| Opening word usually skipped in alphabetizing | 45 |
| Opening words from a TV news reporter | 37 |
| Opening words in a daily journal | 32 |
| Opening words of "A Tale of Two Cities" | 49 |
| Opening words of "Travelin' Man" | 46 |
| Opening words of a 1941 hit song | 32 |
| Opening-night jitters at a famous rock musical? | 47 |
| Openings in the dental profession | 33 |
| Opens a certain type of garment fastener | 40 |
| Opens a tube of toothpaste, e.g. | 32 |
| Opens an envelope at the Oscars, e.g. | 37 |
| Opens up at the doctor's office, perhaps? | 45 |
| Opens up for examination, in a way | 34 |
| Opens, as a change purse, perhaps | 33 |
| Opera "The Golden ---" | 32 |
| Opera "The Tale of ___ Saltan" | 40 |
| Opera ... coloratura ... "Eri tu" | 43 |
| Opera about a hunchbacked jester | 32 |
| Opera about an enslaved Ethiopian girl | 38 |
| Opera about an Ethiopian slave girl | 35 |
| Opera about spellbinding stairs? | 32 |
| Opera based on a Beaumarchais comedy | 36 |
| Opera based on a Shakespeare play | 33 |
| Opera based on two Wedekind plays | 33 |
| Opera boy with 'night visitors' | 39 |
| Opera by today's birthday composer | 38 |
| Opera character who jumps to her death in the end | 49 |
| Opera character who sings "Eri tu" | 44 |
| Opera commissioned by the khedive of Egypt | 42 |
| Opera composer?Donizetti's teacher | 38 |
| Opera fan's opposite of "buffa" | 45 |
| Opera featuring a "grave-digging duet" | 48 |
| Opera featuring a captured princess | 35 |
| Opera featuring Don José and Escamillo | 41 |
| Opera featuring the "Willow Song" | 43 |
| Opera house at Lincoln Center, casually | 39 |
| Opera legend who was close to Onassis | 37 |
| Opera on which "Rent" is based | 40 |
| Opera on which "Rent" was based | 41 |
| Opera performed today, yet neglected | 36 |
| Opera premiere at La Scala in 1887 | 34 |
| Opera premiere: St. Petersburg, 1836 | 36 |
| Opera redone by Elton John and Tim Rice | 39 |
| Opera seen frequently in crosswords | 35 |
| Opera set in Egypt and written by an Italian | 44 |
| Opera set in the age of pharaohs | 32 |
| Opera set in the time of the Pharaohs | 37 |
| Opera set on the banks of the Nile | 34 |
| Opera setting for "Aida" | 34 |
| Opera singer created by Arthur Conan Doyle | 42 |
| Opera singer known as "La Divina" | 43 |
| Opera singer nicknamed "La Divina" | 44 |
| Opera song sung while in the spotlight | 38 |
| Opera song, or a Vegas Strip hotel | 34 |
| Opera star Frances ___: 1883–1952 | 40 |
| Opera subtitled "Wedded Love" | 39 |
| Opera that climaxes with a firing squad | 39 |
| Opera that debuted in Cairo in 1871 | 35 |
| Opera that ends at the Temple of Vulcan | 39 |
| Opera that ends in the Temple of Vulcan | 39 |
| Opera that inspired the T-shirt slogan | 38 |
| Opera that opens on Christmas Eve | 33 |
| Opera that premiered in Cairo in 1871 | 37 |
| Opera that premiered on Christmas Eve of 1871 | 45 |
| Opera title character who dies in a conflagration | 49 |
| Opera title character who drowns | 32 |
| Opera title character who eats a poison leaf | 44 |
| Opera title character who gets dragged into hell | 48 |
| Opera title character who shoots himself | 40 |
| Opera trimmed at both ends by erstwhile actor (9) | 49 |
| Opera with "Ave Maria" | 32 |
| Opera with "O patria mia" | 35 |
| Opera with elephants and Ethiopians | 35 |
| Opera with the aria "Recondita armonia" | 49 |
| Opera with the aria "Vissi d'arte" | 48 |
| Opera with the soprano aria "Ave Maria" | 49 |
| Opera ___ (classical music record label) | 40 |
| Opera ___ (complete works: Lat.) | 32 |
| Opera's "barbiere di qualità " | 46 |
| Opera's "Swedish Nightingale" | 43 |
| Opera's Mario Lanza, for one | 32 |