| ___ up on (studied) | 19 |
| ___ up on (surprise) | 20 |
| ___ up shop | 11 |
| ___ up the flagpole | 19 |
| ___ up to (admit) | 17 |
| ___ up to (approach slyly) | 26 |
| ___ up to (approached) | 22 |
| ___ up to (became genial) | 25 |
| ___ up to (flatter) | 19 |
| ___ up to (indicates) | 21 |
| ___ up with | 11 |
| ___ up with (tolerate) | 22 |
| ___ up, as a horse | 18 |
| ___ up: strengthen | 18 |
| ___ up: surged | 14 |
| ___ upon (comment critically) | 29 |
| ___ upon (find by accident) | 27 |
| ___ upon (meets) | 16 |
| ___ upon (weighed heavily) | 26 |
| ___ upon a time | 15 |
| ___ upon influences | 19 |
| ___ uproar | 10 |
| ___ uproar (tumultuous) | 23 |
| ___ upswing | 11 |
| ___ upswing (improving) | 23 |
| ___ upswing (rising) | 20 |
| ___ Urquelle ("Family Matters" alter ego) | 51 |
| ___ Urundi | 10 |
| ___ Us | 6 |
| ___ use | 7 |
| ___ use (worthless) | 19 |
| ___ usual | 9 |
| ___ Utley, author of "The China Story" | 48 |
| ___ v. Ashcroft (2004 privacy case) | 35 |
| ___ v. Ferguson ("separate but equal" case) | 53 |
| ___ v. United States (classic Supreme Court obscenity case) | 59 |
| ___ v. United States, 1967 decision limiting wiretapping | 56 |
| ___ v. Vitale (landmark Supreme Court case of 1962) | 51 |
| ___ v. Wade | 11 |
| ___ v. Wade (1973 Supreme Court decision) | 41 |
| ___ v. Wade (landmark decision) | 31 |
| ___ vaccine | 11 |
| ___ Vader | 9 |
| ___ Vader (sci-fi guy) | 22 |
| ___ Vader, film villain | 23 |
| ___ vadis | 9 |
| ___ Vaishnavism (Hindu sect) | 28 |
| ___ Valdez | 10 |
| ___ vale (farewell) | 19 |
| ___ Valente (clothing line) | 27 |
| ___ Valjean | 11 |
| ___ Vallarta | 12 |
| ___ Vallarta, Mexico | 20 |
| ___ Valley | 10 |
| ___ Valley ("Back to the Future" locale) | 50 |
| ___ Valley (1960 Olympics site) | 31 |
| ___ Valley (1960 Winter Olympics locale) | 40 |
| ___ Valley (California wine region) | 35 |
| ___ Valley (city near Los Angeles) | 34 |
| ___ Valley (city northwest of Los Angeles) | 42 |
| ___ Valley (home to the Reagan Library) | 39 |
| ___ Valley (Los Angeles suburb) | 31 |
| ___ Valley (Reagan Library city) | 32 |
| ___ Valley (Reagan Library setting) | 35 |
| ___ Valley (Reagan Library site) | 32 |
| ___ Valley (Riverside neighbor) | 31 |
| ___ Valley (San Francisco neighborhood next to The Castro) | 58 |
| ___ Valley (San Francisco neighborhood) | 39 |
| ___ Valley (site of the Ronald Reagan Presidential Library) | 59 |
| ___ Valley (ski resort) | 23 |
| ___ Valley Conference | 21 |
| ___ Valley Conference in college sports | 39 |
| ___ Valley, 2002 Winter Olympics venue | 38 |
| ___ Valley, AZ | 14 |
| ___ Valley, Calif. | 18 |
| ___ Valley, California | 22 |
| ___ Valley, city near L.A. | 26 |
| ___ Valley, German wine region | 30 |
| ___ Valley, Idaho | 17 |
| ___ Valley, San Francisco | 25 |
| ___ Vallis (where the Mars Pathfinder landed) | 45 |
| ___ value | 9 |
| ___ value (car buyer's concern) | 35 |
| ___ value (reasonable price) | 28 |
| ___ value stock | 15 |
| ___ valve | 9 |
| ___ valve (part of an engine) | 29 |
| ___ valve prolapse (heart condition) | 36 |
| ___ valve, in the heart | 23 |
| ___ van Beethoven | 17 |
| ___ van Delft | 13 |
| ___ van Delft, Dutch painter | 28 |
| ___ van der Rohe | 16 |
| ___ Van Duyn, 1991 Pulitzer-winning poet | 40 |
| ___ van Holland, Neth. | 22 |
| ___ Van Huong, Vietnamese Prime Minister: 1965 | 46 |
| ___ Van Kull | 12 |
| ___ Van Winkle | 14 |
| ___ Vance, fictional sleuth | 27 |
| ___ Vance, literary detective | 29 |