| ___ spades | 10 |
| ___ spades (highest card in a deck) | 35 |
| ___ spades (top bridge card) | 28 |
| ___ Spalko, ("Indiana Jones and the Kingdom of the Crystal Skull" villain) | 84 |
| ___ Spalko, Indiana Jones villainess | 36 |
| ___ Spark, creator of Miss Jean Brodie | 38 |
| ___ Sparks, memorable sourpuss | 30 |
| ___ SpÃritus (Cuban city) | 28 |
| ___ speak | 9 |
| ___ speak (as it were) | 22 |
| ___ Speaker | 11 |
| ___ speaking (group recitation) | 31 |
| ___ special | 11 |
| ___ Specter (Pennsylvania senator for 30 years) | 47 |
| ___ Spee | 8 |
| ___ Spee (old German warship) | 29 |
| ___ speed | 9 |
| ___ Speed Wagon (old vehicle) | 29 |
| ___ Speed Wagon (vintage auto) | 30 |
| ___ Speedwagon | 14 |
| ___ Speedwagon ("Keep on Loving You" band) | 52 |
| ___ Speedwagon (1970s-'80s band) | 36 |
| ___ Speedwagon (rock group) | 27 |
| ___ Speedwagon of rock | 22 |
| ___ Speedwagon, rock group | 26 |
| ___ Speedy (photocopying store) | 31 |
| ___ Speedy (rival of Kinko's) | 33 |
| ___ spell | 9 |
| ___ spell (relax) | 17 |
| ___ spell (rest) | 16 |
| ___ spell (took a load off) | 27 |
| ___ spell on | 12 |
| ___ spell over | 14 |
| ___ Spencer, brother of Princess Diana | 38 |
| ___ Spenlow (Dickens girl) | 26 |
| ___ Sperry, aeronautics pioneer | 31 |
| ___ spheroid (football, to sports writers) | 42 |
| ___ Spice (nickname for Victoria Beckham) | 41 |
| ___ Spice (Victoria Beckham) | 28 |
| ___ Spiegel | 11 |
| ___ Spiegel (German magazine) | 29 |
| ___ Spiegel (German newsmagazine) | 33 |
| ___ Spiegel (Hamburger's rag) | 33 |
| ___ Spiegel magazine | 20 |
| ___ spill | 9 |
| ___ Spin (classic toy) | 22 |
| ___ spirit | 10 |
| ___ Spirit (stealth bomber) | 27 |
| ___ spit (kiss) | 15 |
| ___ splicing | 12 |
| ___ splints | 11 |
| ___ splints (jogger's complaint) | 36 |
| ___ split | 9 |
| ___ splitting | 13 |
| ___ sponte | 10 |
| ___ sponte (legal term) | 23 |
| ___ sponte (of its own accord) | 30 |
| ___ sponte (of its own accord, at law) | 38 |
| ___ spoon (cheap cafe): Sl. | 27 |
| ___ Sport (old Pontiac model) | 29 |
| ___ Sportif | 11 |
| ___ Sports Bureau | 17 |
| ___ Sports Bureau (statistics source) | 37 |
| ___ spout (water runoff site) | 29 |
| ___ sprawl | 10 |
| ___ spray | 9 |
| ___ spray (inhaled medication) | 30 |
| ___ spree | 9 |
| ___ spree (rolling) | 19 |
| ___ Spring | 10 |
| ___ Spring (revolution that began in 2010) | 42 |
| ___ Springfield (town eponym on "The Simpsons") | 57 |
| ___ Springs (N.Y. resort) | 25 |
| ___ Springs, Australia | 22 |
| ___ Springs, Fla. | 17 |
| ___ Springs, New York | 21 |
| ___ Sprockets, George Jetson's employer | 43 |
| ___ Sprout of Guided by Voices | 30 |
| ___ Spumante | 12 |
| ___ Spumante (sparkling wine) | 29 |
| ___ Spumante (wine) | 19 |
| ___ Spumante wine | 17 |
| ___ spumanti | 12 |
| ___ Spunkmeyer | 14 |
| ___ Spunkmeyer (cookie company) | 31 |
| ___ Spunkmeyer of cookies | 25 |
| ___ spur | 8 |
| ___ Spy (red-striped apple) | 27 |
| ___ squad | 9 |
| ___ Squad (early hip-hop supergroup) | 36 |
| ___ Squad (support service owned by Best Buy) | 45 |
| ___ Squalor (Lemony Snicket character) | 38 |
| ___ Square | 10 |
| ___ square (honest) | 19 |
| ___ Square (Times Square, once) | 31 |
| ___ Square Cafe (Danny Meyer restaurant) | 40 |
| ___ squares (a statistical method) | 34 |
| ___ squares (statistical method) | 32 |
| ___ squash | 10 |
| ___ squeaky wheel | 17 |