| ___ sienna | 10 |
| ___ sight | 9 |
| ___ sight (fantastic) | 21 |
| ___ sigilli (seal's spot) | 29 |
| ___ Sigma Phi (honor society) | 29 |
| ___ sign (=) | 12 |
| ___ signs | 9 |
| ___ signum | 10 |
| ___ signum (here is the proof) | 30 |
| ___ signum (look at the proof: Lat.) | 36 |
| ___ signum (see the proof) | 26 |
| ___ Sigurdson (Eric Forman's grandmother on "That '70s Show") | 79 |
| ___ Silence, 1989 Kentucky Derby winner | 39 |
| ___ silly question | 18 |
| ___ silly question ... | 22 |
| ___ silver | 10 |
| ___ silver (1890s political issue) | 34 |
| ___ silver platter | 18 |
| ___ Silvia, mother of Romulus and Remus | 39 |
| ___ Simbel | 10 |
| ___ Simbel (Egyptian temple site) | 33 |
| ___ Simbel, Egypt | 18 |
| ___ Simbel, Egypt | 17 |
| ___ Simbel, historic Egyptian site | 34 |
| ___ Simbel, historic site in Egypt | 34 |
| ___ Simbel, Nile landmark | 25 |
| ___ Simbel, on the Nile | 23 |
| ___ Simeon | 10 |
| ___ Simeon, Calif. | 18 |
| ___ simple | 10 |
| ___ Simpson, Southern Open champ: 1985 | 38 |
| ___ Sinatras | 12 |
| ___ since | 9 |
| ___ since (as of) | 17 |
| ___ Sinclair (protagonist of Hesse's "Demian") | 60 |
| ___ sine qua non | 16 |
| ___ singing | 11 |
| ___ Sinha, Sanskrit poet | 24 |
| ___ sinister | 12 |
| ___ sink | 8 |
| ___ sins | 8 |
| ___ sister | 10 |
| ___ Sisters | 11 |
| ___ Sisters (daughters of Atlas) | 32 |
| ___ Sisters (Shakespearean witches) | 35 |
| ___ Sisters of "Macbeth" | 34 |
| ___ Six (Louisiana group who was the focus of 2007 rallies) | 59 |
| ___ Six-Pack | 12 |
| ___ size (cut down) | 19 |
| ___ Skavinsky Skavar | 20 |
| ___ Skelton, chairman of the House Armed Services Committee | 59 |
| ___ Sketch | 10 |
| ___ Sketch (classic drawing toy) | 32 |
| ___ sketch (concise description) | 32 |
| ___ Sketch (drawing toy) | 24 |
| ___ Sketch (popular drawing toy) | 32 |
| ___ Sketch (toy) | 16 |
| ___ Sketch: toy | 15 |
| ___ ski | 7 |
| ___ Ski Valley | 14 |
| ___ Ski Valley (western resort) | 31 |
| ___ Ski Valley, N.M. | 20 |
| ___ skiing | 10 |
| ___ Skip Day | 12 |
| ___ Skip Day (high-school celebration of truancy) | 49 |
| ___ skirt | 9 |
| ___ skirt (luau attire) | 23 |
| ___ sky (altocumulus expanse) | 29 |
| ___ Skye (Donovan's daughter) | 33 |
| ___ Skywalker of "Star Wars" | 38 |
| ___ Slaughter, former Cardinal | 30 |
| ___ slaw | 8 |
| ___ sleep | 9 |
| ___ sleeve (held secretly) | 26 |
| ___ Slim (noted poker player) | 29 |
| ___ slip | 8 |
| ___ slip (certain wardrobe malfunction) | 39 |
| ___ slipper (orchid type) | 25 |
| ___ Slobbovia (remote locale) | 29 |
| ___ Sloper (1915 Grand National winner) | 39 |
| ___ slow boat to China | 22 |
| ___ small world | 15 |
| ___ smasher | 11 |
| ___ smear (annual exam for some) | 32 |
| ___ smile (grin) | 16 |
| ___ Smiley of "Sesame Street" | 39 |
| ___ Smith | 9 |
| ___ Smith (apple variety) | 25 |
| ___ Smith (green apple) | 23 |
| ___ Smith of N.F.L. fame | 24 |
| ___ Smith's pies | 20 |
| ___ Smith, O'Neill hero | 27 |
| ___ Smith, who won the 1972 Wimbledon | 37 |
| ___ smoke | 9 |
| ___ snag (encounters trouble) | 29 |
| ___ snag (experience difficulty) | 32 |
| ___ snag (finds trouble) | 24 |
| ___ snag (have trouble) | 23 |
| ___ snail's pace | 20 |
| ___ Snaps (dog treats) | 22 |