| ___ in the headlights | 21 |
| ___ in the hole | 15 |
| ___ in the neck | 15 |
| ___ in the ocean | 16 |
| ___ in the ocean (poker variety) | 32 |
| ___ in the park | 15 |
| ___ in the right direction | 26 |
| ___ in the room | 15 |
| ___ in the saddle | 17 |
| ___ in the sky | 14 |
| ___ in the sky (empty wish) | 27 |
| ___ in the sun | 14 |
| ___ in the wind | 15 |
| ___ in the wood | 15 |
| ___ in the woods | 16 |
| ___ in the wool | 15 |
| ___ in Thomas | 13 |
| ___ in turkey | 13 |
| ___ in turkey (part of a kindergarten lesson) | 45 |
| ___ in U.S.A. | 13 |
| ___ in Victor | 13 |
| ___ in victory | 14 |
| ___ in volcano | 14 |
| ___ in wait | 11 |
| ___ in wait (lurk) | 18 |
| ___ in wait (ready to ambush) | 29 |
| ___ in xylophone | 16 |
| ___ in years | 12 |
| ___ Inch Nails | 14 |
| ___ incline | 11 |
| ___ incline (tilted) | 20 |
| ___ incognita | 13 |
| ___ incognita (unexplored region) | 33 |
| ___ income | 10 |
| ___ Independent Press Awards | 28 |
| ___ Indian | 10 |
| ___ Indian War | 14 |
| ___ Industrial Region, in Russia | 32 |
| ___ Industries (defense contractor) | 35 |
| ___ Industries (oil giant) | 26 |
| ___ infallibility (Roman Catholic dogma) | 40 |
| ___ infaustus (unlucky day) | 27 |
| ___ infection | 13 |
| ___ inflation (campaign issue) | 30 |
| ___ infra (see below) | 21 |
| ___ inglese (tiered sponge cake dessert from Italy) | 51 |
| ___ inhibitor | 13 |
| ___ iniquity | 12 |
| ___ injection | 13 |
| ___ Injun | 9 |
| ___ Inn | 7 |
| ___ Inn (birthplace of a certain cookie) | 40 |
| ___ insects (varnish resin source) | 34 |
| ___ Inside (store sign) | 23 |
| ___ instant | 11 |
| ___ instant (at once) | 21 |
| ___ instant (immediately) | 25 |
| ___ instant (promptly) | 22 |
| ___ instant (quickly) | 21 |
| ___ instant (right away) | 24 |
| ___ instant (suddenly) | 22 |
| ___ instant (swiftly) | 21 |
| ___ instant (very quickly) | 26 |
| ___ instinct | 12 |
| ___ instincts | 13 |
| ___ Institute (Charles Koch's think tank) | 45 |
| ___ Institute (D.C. think tank) | 31 |
| ___ Institute (UFO-monitoring org.) | 35 |
| ___ Institute for Biological Studies | 36 |
| ___ Institute, California retreat center for alternative education | 66 |
| ___ Institute, in Brooklyn | 26 |
| ___ Institute, org. that makes use of the Allen Telescope Array | 63 |
| ___ instruction | 15 |
| ___ instrument | 14 |
| ___ insult to injury | 20 |
| ___ insurance | 13 |
| ___ integra | 11 |
| ___ intents and purposes | 24 |
| ___ interface | 13 |
| ___ interference (baseball ruling) | 34 |
| ___ International (human rights watchdogs) | 42 |
| ___ International Speedway | 26 |
| ___ International, 1977 Nobel Peace Prize winner | 48 |
| ___ interview | 13 |
| ___ into (assail) | 17 |
| ___ into (assailed) | 19 |
| ___ into (attack strongly) | 26 |
| ___ into (attacks vigorously) | 29 |
| ___ into (attacks) | 18 |
| ___ into (get started) | 22 |
| ___ into (gets by chance) | 25 |
| ___ into (gets going) | 21 |
| ___ into (pries) | 16 |
| ___ into holy matrimony | 23 |
| ___ into tears (started crying) | 31 |
| ___ Intrepid | 12 |
| ___ Invalides (Paris landmark) | 30 |
| ___ Investments (Boston-based financial company) | 48 |
| ___ Invictus (Roman god) | 24 |
| ___ Ionienne | 12 |