| ___ du Vent | 11 |
| ___ du Vent (the Windwards) | 27 |
| ___ du Vent (Windward Islands) | 30 |
| ___ du ventre | 13 |
| ___ du ventre (belly dance) | 27 |
| ___ Duarte Perón | 19 |
| ___ Dubai (world's tallest skyscraper, as of 2009) | 54 |
| ___ Dubos, humanist who said "Think globally, act locally" | 68 |
| ___ Dubos, Pulitzer winner for "So Human an Animal" | 61 |
| ___ duck | 8 |
| ___ duck (Chinese dish) | 23 |
| ___ duck (losing politician serving out a term) | 47 |
| ___ duck (reelection loser) | 27 |
| ___ duck (restaurant dish) | 26 |
| ___ duck (waddles) | 18 |
| ___ due (matured) | 17 |
| ___ Duke (tobacco magnate) | 26 |
| ___ Duke, a.k.a. Hunter S. Thompson | 35 |
| ___ Dunbar (nom de puzzle/anagram of Patrick Blindauer) | 55 |
| ___ dunk | 8 |
| ___ Dunkers (oblong cookies) | 28 |
| ___ Durbeyfield, Hardy heroine | 30 |
| ___ Duren, former pitcher | 25 |
| ___ Duro Canyon, Tex. | 21 |
| ___ dust | 8 |
| ___ dust (so-o-o boring) | 24 |
| ___ Dutch (clothing company) | 28 |
| ___ Dutch clothing | 18 |
| ___ Duyvil, N.Y. | 16 |
| ___ dye | 7 |
| ___ dye (chemical coloring) | 27 |
| ___ dyed (did a coloring job) | 29 |
| ___ Dykstra, former Met | 23 |
| ___ dynamics | 12 |
| ___ E (TV channel) | 18 |
| ___ e bisi, Italian dish | 24 |
| ___ e bisi, Venetian dish | 25 |
| ___ e sempre | 12 |
| ___ e sempre (Italian motto) | 28 |
| ___ e sempre (now and always): It. | 34 |
| ___ E. Coyote | 13 |
| ___ E. Coyote of cartoons | 25 |
| ___ E. Lee | 10 |
| ___ E. Lee: Abbr. | 17 |
| ___ E. Neuman | 13 |
| ___ E. Tee (1992 Kentucky Derby winner) | 39 |
| ___ Eads, engineer who built the world's first steel-truss bridge | 69 |
| ___ eagle | 9 |
| ___ ear | 7 |
| ___ ear (hearkened) | 19 |
| ___ ear (ignores) | 17 |
| ___ ear (listen) | 16 |
| ___ ear (listened) | 18 |
| ___ ear . . . | 13 |
| ___ ear and . . . | 17 |
| ___ ear and . . . (unconcerned) | 31 |
| ___ ear and out . . . | 21 |
| ___ ear and out the other | 25 |
| ___ early age | 13 |
| ___ Early, C.S.A. general | 25 |
| ___ earnings (phrase used when comparing a current and upcoming paycheck) | 73 |
| ___ Earth | 9 |
| ___ earth (track down) | 22 |
| ___ ease | 8 |
| ___ ease (anxious) | 18 |
| ___ ease (edgy) | 15 |
| ___ ease (nervous) | 18 |
| ___ ease (relax someone) | 24 |
| ___ ease (relieve one's mind) | 33 |
| ___ ease (restless) | 19 |
| ___ ease (uncomfortable) | 24 |
| ___ East | 8 |
| ___ Easton Ellis, author of "American Psycho" | 55 |
| ___ easy | 8 |
| ___ easy (eggs order) | 21 |
| ___ eaten | 9 |
| ___ eater | 9 |
| ___ Eban of Israel | 18 |
| ___ ecclesiasticae (church matters) | 35 |
| ___ eclipse | 11 |
| ___ economics | 13 |
| ___ Ed | 6 |
| ___ ed (gym class) | 18 |
| ___ ed class | 12 |
| ___ Ed. | 7 |
| ___ ed. (gym class) | 19 |
| ___ ed. (H.S. course) | 21 |
| ___ edge (countertop option) | 28 |
| ___ Edibles (food shop on "The Facts of Life") | 56 |
| ___ education | 13 |
| ___ education (college and beyond) | 34 |
| ___ eel | 7 |
| ___ effect (1883 physics discovery) | 35 |
| ___ effect (atmospheric heating phenomenon) | 43 |
| ___ effort | 10 |
| ___ effort (award for trying hard) | 34 |
| ___ Egadi (islands off Sicilia) | 31 |
| ___ egg | 7 |
| ___ egg (bomb) | 14 |
| ___ egg (flop) | 14 |