| __ Romana | 9 |
| __ Romeo | 8 |
| __ Romeo (imported auto) | 24 |
| __ Romeo (imported car) | 23 |
| __ Romeo (Italian auto) | 23 |
| __ Romeo (sports car) | 21 |
| __ Romeo Spider | 15 |
| __ Romeo: Italian sports car | 28 |
| __ Romeo: sports car | 20 |
| __ room | 7 |
| __ room (family place) | 22 |
| __ room (place to play) | 23 |
| __ room (play area) | 19 |
| __ room (play space) | 20 |
| __ room: play area | 18 |
| __ root | 7 |
| __ Rosalynn Carter | 18 |
| __ roses | 8 |
| __ Rossi: wine brand | 20 |
| __ Rouge | 8 |
| __ Rouge (Paris nightclub) | 26 |
| __ Royale National Park | 23 |
| __ Royale: Lake Superior national park | 38 |
| __ rug | 6 |
| __ rug: dance | 13 |
| __ rule | 7 |
| __ rule (generally) | 19 |
| __ Sabe | 7 |
| __ Sabe: Lone Ranger nickname | 29 |
| __ Sad, Serbia | 14 |
| __ Said: Suez Canal harbor | 26 |
| __ salad | 8 |
| __ salad (main course) | 22 |
| __ sale | 7 |
| __ salt | 7 |
| __ salts | 8 |
| __ salts (bath additive) | 24 |
| __ salts (drug-store purchase) | 30 |
| __ salts (drugstore buy) | 24 |
| __ salts (medicinal compound) | 29 |
| __ Sam: 49ers mascot | 20 |
| __ Samaritan | 12 |
| __ San Lucas: Baja resort | 25 |
| __ sanctum | 10 |
| __ santo: Spanish graveyard | 27 |
| __ sapiens | 10 |
| __ sauce (Chinese condiment) | 28 |
| __ sauce: seafood serving | 25 |
| __ Sauer: handgun | 17 |
| __ sax | 6 |
| __ say (unfortunately) | 22 |
| __ says (kids' game) | 24 |
| __ scale (hardness measure) | 27 |
| __ scale: talc-to-diamond | 25 |
| __ scan: ID method | 18 |
| __ Schayes, who held the NBA career scoring record when he retired in 1964 | 74 |
| __ schedule (late) | 18 |
| __ scheme | 9 |
| __ scholar | 10 |
| __ school | 9 |
| __ Schwarz | 10 |
| __ Schwarz: 5th Avenue toy store | 32 |
| __ Schwarz: NYC toy store | 25 |
| __ sci | 6 |
| __ sci (college course) | 23 |
| __ sci (college major) | 22 |
| __ sci. | 7 |
| __ score: neonatal evaluation | 29 |
| __ Scotia | 9 |
| __ Scotia, Canada | 17 |
| __ Scott Decision | 17 |
| __ Scott Decision (1857) | 24 |
| __ Scott Forester | 17 |
| __ scout | 8 |
| __ scratch | 10 |
| __ screen: health care test for poisons, drugs, etc. | 52 |
| __ screen: medical test | 23 |
| __ scripta: written law | 23 |
| __ se | 5 |
| __ Sea | 6 |
| __ Sea (Arctic Ocean arm) | 25 |
| __ Sea (Asian lake) | 19 |
| __ Sean Connery | 15 |
| __ search (county clerk's task) | 35 |
| __ season | 9 |
| __ seat | 7 |
| __ Sebastian Bach | 17 |
| __ seeds (bun features) | 23 |
| __ seeds (bun topping) | 22 |
| __ seeds (burger-bun feature) | 29 |
| __ Selassie | 11 |
| __ Selassie (Ethiopian emperor) | 31 |
| __ self-defense | 15 |
| __ sequence | 11 |
| __ sequencing | 13 |
| __ sequitur | 11 |
| __ sequitur: illogical conclusion | 33 |
| __ Series | 9 |
| __ Series (October baseball event) | 34 |
| __ Series: auto races | 21 |