| One of the ASPCA's "Ways to Help" | 47 |
| One of the authors in the game Authors | 38 |
| One of the “Star Trek” series, to fans | 46 |
| One of the Baltimore Ravens' mascots | 40 |
| One of the Beatles' song girls | 34 |
| One of the Big Four record labels | 33 |
| One of the Big Three in credit reports | 38 |
| One of the Big Three of science fiction | 39 |
| One of the biggest fights in boxing history | 43 |
| One of the black keys on a piano | 32 |
| One of the Bobbsey twins of fiction | 35 |
| One of the Bonin Islands, for short | 35 |
| One of the books in the Book of Mormon | 38 |
| One of the Bradys on "The Brady Bunch" | 48 |
| One of the brands of Yum! Brands | 32 |
| One of the brothers of Warner Bros. | 35 |
| One of the buddies of "Bosom Buddies" | 47 |
| One of the Carpenters, in 1970s pop | 35 |
| One of the Carringtons on "Dynasty" | 45 |
| One of the cats in "Cats" | 35 |
| One of the cattle in a cattle drive | 35 |
| One of the Central Provinces: Abbr. | 35 |
| One of the Challenger astronauts | 32 |
| One of the classical architectural orders | 41 |
| One of the co-founders of Wikipedia | 35 |
| One of the Colonial Colleges, informally | 40 |
| One of the compound spots on a leopard | 38 |
| One of the Conners on "Roseanne" | 42 |
| One of the convicted Rosenberg spies | 36 |
| One of the Coreys on "The Two Coreys" | 47 |
| One of the Corleones (FOR ED anag.) | 35 |
| One of the corners at Four Corners Monument | 43 |
| One of the Costanzas, on "Seinfeld" | 45 |
| One of the d's in "3-D" | 37 |
| One of the deepest lakes in the U.S. | 36 |
| One of the Dixie Chicks or the Brontës | 41 |
| One of the Dow Jones Industrials | 32 |
| One of the eight states bordering Tenn. | 39 |
| One of the eight vegetables in V8 | 33 |
| One of the Ewings on "Dallas" | 39 |
| One of the Ewings, on "Dallas" | 40 |
| One of the filmmaking Coen brothers | 35 |
| One of the financial markets, for short | 39 |
| One of the first Buicks to roll off the line? | 45 |
| One of the first people mentioned in Genesis | 44 |
| One of the first ships to arrive in America | 43 |
| One of the first to raise a hand, usually | 41 |
| One of the first TV cartoon serials | 35 |
| One of the first TV superstations | 33 |
| One of the five "Greats" | 34 |
| One of the five basic taste sensations | 38 |
| One of the five Beijing Olympics mascots | 40 |
| One of the five chief cities of the Philistines | 47 |
| One of the Five Civilized Nations | 33 |
| One of the five major circles of latitude | 41 |
| One of the five major taste sensations | 38 |
| One of the five related names in this puzzle | 44 |
| One of the Flagston family, in the funnies | 42 |
| One of the Flagstons, in the funnies | 36 |
| One of the former Barbary States | 32 |
| One of the former Big Three in news | 35 |
| One of the four ancient elements | 32 |
| One of the Four Corners states: Abbr. | 37 |
| One of the four elements of hip hop | 35 |
| One of the four elements, in alchemy | 36 |
| One of the four evangelists, briefly | 36 |
| One of the Four Horsemen of the Apocalypse | 42 |
| One of the four players in "Gauntlet" | 47 |
| One of the four seasons, in France | 34 |
| One of the four states of matter | 32 |
| One of the four suits in the Minor Arcana | 41 |
| One of the friends on "Friends" | 41 |
| One of the girls on 'The Facts of Life' | 47 |
| One of the girls on "The Waltons" | 43 |
| One of the Gospels, in a Spanish Bible | 38 |
| One of the grains in Nutri-Grain | 32 |
| One of the great cities of antiquity | 36 |
| One of the greatest center fielders of all time | 47 |
| One of the heroines of an 1868 novel | 36 |
| One of the highest order of angels | 34 |
| One of the hunters in "The Deer Hunter" | 49 |
| One of the Jacksonville Jaguars's team colors | 49 |
| One of the Jays, Rays, or A's | 33 |
| One of the Jets' Super Bowl heroes | 38 |
| One of the Kennedys, and namesakes | 34 |
| One of the King Sisters of 40's music | 41 |
| One of the L.A. Rams' Fearsome Foursome | 43 |
| One of the leaders on a talk show | 33 |
| One of the little things in life? | 33 |
| One of the losers in the War of the Pacific | 43 |
| One of the Louisiana Purchase negotiators | 41 |
| One of the major leagues (abbr.) | 32 |
| One of the major leagues, briefly | 33 |
| One of the major world religions | 32 |
| One of the Maritime Provinces: Abbr. | 36 |
| One of the Marshall Islands' 29 | 35 |
| One of the Mayos in the Land of Lakes | 37 |
| One of the men on "Two and a Half Men" | 48 |
| One of the mice in "Cinderella" | 41 |
| One of the Mitchells in an old UPN sitcom | 41 |