| One First Lady's maiden name | 32 |
| One fleeing persecution, perhaps | 32 |
| One floundering in strange surroundings | 39 |
| One following a bellwether, maybe | 33 |
| One for the "no" column | 33 |
| One for whom a street may be named | 34 |
| One for whom all roads lead to roam | 35 |
| One for whom all roads lead to roam? | 36 |
| One for whom Apr. is the cruelest month? | 40 |
| One for whom glasses are clinked | 32 |
| One for whom many angles may be right? | 38 |
| One for whom nothing's good enough | 38 |
| One for whom silicosis is an occupational hazard | 48 |
| One for whom the play's the thing | 37 |
| One for whom there's no hope | 32 |
| One for whose benefit a legal suit is brought | 45 |
| One forbidden to kiss for pleasure | 34 |
| One form of a multiform organism | 32 |
| One form of the Egyptian god Set | 32 |
| One found in a zebra crossing, for short | 40 |
| One found in a zebra crossing, maybe | 36 |
| One found just around the block? | 32 |
| One found on a computer screen or movie screen | 46 |
| One frequently taken advantage of | 33 |
| One frequently taking a time out | 32 |
| One from column A, one from column B, etc. | 42 |
| One from the Leaning Tower's city | 37 |
| One from Tripolis, in ancient Greece | 36 |
| One from whom property is transferred | 37 |
| One full of surprises or shocking news, e.g. | 44 |
| One generating a lot of interest? | 33 |
| One getting a single or a double, e.g. | 38 |
| One getting a tan the old-fashioned way | 39 |
| One getting laughs at others' expense | 41 |
| One getting lots of doubles and home runs, say | 46 |
| One getting messages by word of mouth? | 38 |
| One getting on-the-job-training, maybe | 38 |
| One getting one-on-one instruction | 34 |
| One getting out before the storm | 32 |
| One getting same-day medical service, maybe | 43 |
| One getting strokes, in a good way | 34 |
| One getting stuck in a horror movie | 35 |
| One given "unto us," in Isaiah | 40 |
| One given a red-carpet reception | 32 |
| One given away by her father, often | 35 |
| One given to sprees on horseback? | 33 |
| One giving shots on a horse farm? | 33 |
| One giving Starbuck's orders | 32 |
| One goes along the 38th parallel, briefly | 41 |
| One goes through these to get to the majors | 43 |
| One going back and forth to work | 32 |
| One going back and forth to work? | 33 |
| One going from theater to theater? | 34 |
| One going on long Saturday bike rides, maybe | 44 |
| One going over telemarketing lines | 34 |
| One going through a tunnel, perhaps | 35 |
| One going through papers in a safe, say | 39 |
| One going through the exercises? | 32 |
| One going to Afghanistan, probably | 34 |
| One good at forming connections with others | 43 |
| One good turn leading to another? | 33 |
| One great baseball play after another? | 38 |
| One greeted with a "howdy" | 36 |
| One griping about being knocked off | 35 |
| One half of "Mr. Show" | 32 |
| One half of an iconic 1981 Rolling Stone cover | 46 |
| One hanging around at Red Lobster? | 34 |
| One has feathers, the other has scales | 38 |
| One having a ball at the circus? | 32 |
| One having trouble with his sisters? | 36 |
| One heading down a slippery slope | 33 |
| One heading the office of student roasts? | 41 |
| One helped raise Romulus and Remus | 34 |
| One helping with filing, for short | 34 |
| One hidden by Victorian clothing | 32 |
| One hit might result in it, for short | 37 |
| One holding a sign at the airport, e.g. | 39 |
| One holding up a sign at the airport, e.g. | 42 |
| One hopping along the Cape Cod coast? | 37 |
| One hot for cock (in a sexual sense) | 36 |
| One hour of "The Apprentice" per week? | 48 |
| One if by land, two if by sea, e.g. | 35 |
| One if by land, two if by sea, etc. | 35 |
| One illegally using a handicapped space? | 40 |
| One in "another fine mess" | 36 |
| One in a "Flying" circus act | 38 |
| One in a blue state majority: Abbr. | 35 |
| One in a dependent relationship? | 32 |
| One in a high-risk insurance group | 34 |
| One in a line at J.F.K. or La Guardia | 37 |
| One in a midlife crisis, perhaps | 32 |
| One in a multiple birth, briefly | 32 |
| One in a side-by-side food competition | 38 |
| One in a small-claims court case | 32 |
| One in an ethnic enclave, perhaps | 33 |
| One in an express checkout count | 32 |
| One in an extra-large baby carriage, perhaps | 44 |
| One in charge of a ship's rigging | 37 |
| One in charge of breakfast at the Pentagon? | 43 |
| One in charge of discipline, maybe | 34 |