| Obesity drug Orlistat, more familiarly | 38 |
| Obey an "applaud" sign | 32 |
| Obey an octagon-shaped road sign | 32 |
| Obeyed "Down in front!" | 33 |
| Obeyed a cry of "Down in front!" | 42 |
| Obeyed a dentist's directive | 32 |
| Obeyed a doctor holding a tongue depressor | 42 |
| Obeyed Horace Greeley, as a young man? | 38 |
| Obeying doctor's orders, perhaps | 36 |
| Obi-Wan ('Star Wars' role) -- | 37 |
| Obi-Wan ___ of "Star Wars" | 36 |
| Obit for an Indianapolis newspaper? | 35 |
| Object associated with a saint, e.g. | 36 |
| Object at the beginning of a hole | 33 |
| Object behind a fast food counter | 33 |
| Object believed to have magical powers | 38 |
| Object burned in "Citizen Kane" | 41 |
| Object frequently painted by Degas | 34 |
| Object held by some Monet subjects | 34 |
| Object in the right hand of the king of clubs | 45 |
| Object intentionally dropped on the floor | 41 |
| Object labeled with a letter in court | 37 |
| Object of 60's protest: Abbr. | 33 |
| Object of 60's protests: Abbr. | 34 |
| Object of a conquistador's quest | 36 |
| Object of a doctor's office phobia | 38 |
| Object of a graduate's quest | 32 |
| Object of a hunt in a 1984 best seller | 38 |
| Object of a knight's affection | 34 |
| Object of a medieval knight's quest | 39 |
| Object of a misanthrope's malice | 36 |
| Object of a noted 1999 protest in Seattle | 41 |
| Object of a Ponce de León search | 35 |
| Object of a scurrilous attack, maybe | 36 |
| Object of a tax lawyer's search | 35 |
| Object of an eHarmony.com user's search | 43 |
| Object of an Indiana Jones quest | 32 |
| Object of an insult from Gordon Ramsay? | 39 |
| Object of ancient Egyptian veneration | 37 |
| Object of Androcles' beneficence | 36 |
| Object of Cavaradossi's affection | 37 |
| Object of contemplation during omphaloskepsis | 45 |
| Object of curiosity on the first day of school | 46 |
| Object of Ed Grimley's obsession | 36 |
| Object of Emerson's "high respect" | 48 |
| Object of incense burning, maybe | 32 |
| Object of Indiana Jones's first quest | 41 |
| Object of Indiana Jones's quest | 35 |
| Object of Jimmie Buffet's search | 36 |
| Object of Jimmy Buffett's search | 36 |
| Object of Othello's jealousy | 32 |
| Object of Pepe Le Pew's quest | 33 |
| Object of Petrarch's affection | 34 |
| Object of Petrarch's passion | 32 |
| Object of prayers five times a day | 34 |
| Object of Rimsky-Korsakov's flight | 38 |
| Object of scrutiny at airport security | 38 |
| Object of some cable TV "Wars" | 40 |
| Object of the 1981 hit “Woman” | 38 |
| Object of Thomas Paine's scorn | 34 |
| Object of veneration in ancient Egypt | 37 |
| Object of Vronsky's love, in literature | 43 |
| Object of worship in the Basilica di San Pietro | 47 |
| Object often cut in office pranks | 33 |
| Object on the back of a dollar bill | 35 |
| Object on the back of Georgia's quarter | 43 |
| Object on which ropes are belayed | 33 |
| Object retrieved on an Apollo mission | 37 |
| Object rising in a Van Gogh landscape | 37 |
| Object that'll wake a princess | 34 |
| Object thrown at a cheating husband? | 36 |
| Object thrown at a demonstration? | 33 |
| Object under a magnifying glass, maybe | 38 |
| Object used for Halloween pranking? | 35 |
| Object with three round projections | 35 |
| Objected to a shearing, possibly | 32 |
| Objection on the grounds of scruples | 36 |
| Objective case of "thou" | 34 |
| Objective of some two-year plans | 32 |
| Objectives of some night students: Abbr. | 40 |
| Objector to "nattering nabobs" | 40 |
| Objects contemplated during omphaloskepsis | 42 |
| Objects decorated with a black alloy | 36 |
| Objects employed to show everyday life | 38 |
| Objects for "Ryan's Express" | 42 |
| Objects in a phrase about daftness | 34 |
| Objects of computer instructions | 32 |
| Objects of Wayne and Garth's fancy | 38 |
| Objects too small to be specified | 33 |
| Objects with drawers for drawers | 32 |
| Obligation (or where it might fall?) | 36 |
| Obligation payable within a year (37) | 37 |
| Obligations requiring payment in hay? | 37 |
| Obligatory contribution of a sort | 33 |
| Oblique-angled, four-sided figure | 33 |
| Obliterate, with "down" | 33 |
| Oblong appetizer served with crackers | 37 |
| Obnoxious coinage by Rush Limbaugh | 34 |
| Obnoxious Presidential advisers? | 32 |
| Oboes' lower-pitched cousins | 32 |