| What one in need may need | 25 |
| What one is advised not to quit | 31 |
| What one is done with? | 22 |
| What one is not | 15 |
| What one is not? | 16 |
| What one isn't | 18 |
| What one isn't? | 19 |
| What one liquid said to the other liquid? | 41 |
| What one little pig had | 23 |
| What one little piggie had | 26 |
| What one little piggy had | 25 |
| What one may be by virtue of a spot check? | 42 |
| What one may be taken for? | 26 |
| What one may break during exercise | 34 |
| What one may decide to do with a sigh | 37 |
| What one may do to a joint? | 27 |
| What one may do when one speaks up? | 35 |
| What one may reveal on Facebook | 31 |
| What one may see on a Cree's knee | 37 |
| What one may slip into | 22 |
| What one may win by | 19 |
| What one might beg to do | 24 |
| What one might do after a firing | 32 |
| What one might do after looking | 31 |
| What one might do for compliments | 33 |
| What one might do in the forest? | 32 |
| What one might do with one's fancy | 38 |
| What one might get typecast in | 30 |
| What one might go for a spin in? | 32 |
| What one might pick up in a bar | 31 |
| What one might return to after a slump | 38 |
| What one might sink to | 22 |
| What one might sneak out on | 27 |
| What one might stop to do? | 26 |
| What one might swim in | 22 |
| What one must do if the backhoe won't work? | 47 |
| What one must do to be a gourmand | 33 |
| What one must have to solve this puzzle's theme answers | 59 |
| What one needs to get by | 24 |
| What one needs to ride the tram | 31 |
| What one needs to spot this puzzle's theme? | 47 |
| What one of Nigel's amps goes to in "This Is Spinal Tap" | 70 |
| What one of the five Olympic rings represents | 45 |
| What one of the five Olympic rings stands for | 45 |
| What one of the hypocycloids in the Pittsburgh Steelers' logo represents | 76 |
| What one of the little pigs had in "This Little Pig" | 62 |
| What one often sees Homer do to Bart Simpson? | 45 |
| What one places at rocker auction | 33 |
| What one plays pool with? | 25 |
| What one should call | 20 |
| What one should let | 19 |
| What one should take in: Abbr. | 30 |
| What one shouldn't do in a crowded theater | 46 |
| What one slamming on the brakes may come to | 43 |
| What one spouse may want the other to have at the bank | 54 |
| What one star may mean | 22 |
| What one swallow doesn't make | 33 |
| What one takes in | 17 |
| What one takes to advance | 25 |
| What one toils for | 18 |
| What one undecillion contains | 29 |
| What one used to do in Kremlin heat? | 36 |
| What one wears | 14 |
| What one with "bills, bills, bills" has | 49 |
| What one with a good hand might say | 35 |
| What one with a small nest egg enjoys? | 38 |
| What one with the jitters has | 29 |
| What one's got to do on the disco 'round, oh yea | 56 |
| What one's reach should exceed | 34 |
| What one? | 9 |
| What oneirocritics give | 23 |
| What oneirocritics interpret | 28 |
| What OneRepublic does after stopping | 36 |
| What OneRepublic does before they "Stare"? | 52 |
| What online chatters may do | 27 |
| What online shoppers may spend | 30 |
| What only a select few might get | 32 |
| What only Obama and Clinton have, among U.S. Presidents | 55 |
| What only one Best Picture winner has had | 41 |
| What only twin planes can accomplish? | 37 |
| What opening band is on? | 24 |
| What opens and closes safes? | 28 |
| What opens easily? | 18 |
| What opera fans get | 19 |
| What Operation Desert Storm began with | 38 |
| What opinions often do | 22 |
| What opium addicts hit | 22 |
| What opponents take | 19 |
| What opposites are written down on? | 35 |
| What opposites do | 17 |
| What opposites do, they say | 27 |
| What optimistic astronauts do? | 30 |
| What optimists have | 19 |
| What Oriental is to relation | 28 |
| What Orpheus plucked | 20 |
| What orzo looks like | 20 |
| What Oscar Madison wasn't | 29 |
| What Oscar winner's do at the podium | 40 |
| What oscillating fans do | 24 |
| What osmics is the study of | 27 |