| Much too big for one's britches? | 36 |
| Much-advertised exercise program | 32 |
| Much-anticipated books get a lot of them | 40 |
| Much-anticipated Paris debut of 1992 | 36 |
| Much-anticipated spring thing: Abbr. | 36 |
| Much-bombed Romanian city of W.W.II | 35 |
| Much-criticized Congressional spending | 38 |
| Much-criticized Hurricane Katrina responder | 43 |
| Much-debated school subject, for short | 38 |
| Much-derided early 2000s Pontiac SUV | 36 |
| Much-devalued holding, in modern lingo | 38 |
| Much-discussed initials of a 1967 Beatles song | 46 |
| Much-discussed sociopolitical phenomenon | 40 |
| Much-followed ratings, with "the" | 43 |
| Much-hyped NASDAQ event for Facebook | 36 |
| Much-hyped software release of 2007 | 35 |
| Much-maligned imports of the 1980s | 34 |
| Much-medaled professional skateboarder | 38 |
| Much-mistrusted name in news, once | 34 |
| Much-mocked car of the late 1980s | 33 |
| Much-mocked Clintonian rationalization | 38 |
| Much-mocked smooth jazz musician | 32 |
| Much-performed work set in Nagasaki | 35 |
| Much-photographed White House area | 34 |
| Much-put-upon Biblical character | 32 |
| Much-recorded country tune of 1936 | 34 |
| Much-repeated part of binary code | 33 |
| Much-repeated word in air traffic control | 41 |
| Much-seen figure on a security cam | 34 |
| Mud bogger's purchase, briefly | 34 |
| Muddled situation at the bean curd plant? | 41 |
| Muddy footprints, worn patches, cat hair, etc.? | 47 |
| Muddy Waters "Trouble ___" | 36 |
| Muddy Waters' "Got My ___ Working" | 48 |
| Mudville's most famous batter | 33 |
| Mueller-Stahl of "Shine" | 34 |
| Mugger waiting in the wings, maybe | 34 |
| Mughal Empire capital of the 16th-17th century | 46 |
| Muhammad Ali's boxing daughter | 34 |
| Muhammad who refereed the first WrestleMania | 44 |
| Muhammad's footstep-following daughter | 42 |
| Muhammad's last and MacGraw's first | 43 |
| Muhammad's pugilistic daughter | 34 |
| Muhammad's super middleweight daughter | 42 |
| Muhammed Ali went on one in 1989 | 32 |
| Mulberry and Henry Sts., etc., N.Y.C. | 37 |
| Mulberry, in a Dr. Seuss classic | 32 |
| Mulcahy of "MASH," for one | 36 |
| Mulcahy on "M*A*S*H," e.g. | 36 |
| Muldaur's "___ Woman" | 35 |
| Mulder and Scully show for the blind? | 37 |
| Mulder and Scully's paranormal cases | 40 |
| Mulder and Scully's transport? | 34 |
| Mulder of "The X-Files," for one | 42 |
| Mulder's "X-Files" partner | 40 |
| Mulder's partner on "The X-Files" | 47 |
| Mule "on the Erie Canal" | 34 |
| Mule of ''The Erie Canal'' | 42 |
| Mulgrew of "Star Trek: Voyager" | 41 |
| Mullah ___, former Afghan leader | 32 |
| Mullally of "Bee Movie" | 33 |
| Mullally of "Will & Grace" | 40 |
| Mullally on "Will & Grace" | 40 |
| Mullen's "Man of ___" | 35 |
| Multi-award-winning role for Ferrer | 35 |
| Multi-colored garment of a jester | 33 |
| Multi-continent charity concert held on 7/7/07 | 46 |
| Multi-Emmy-winning NBC sportscaster | 35 |
| Multi-faceted home entertainment gadget | 39 |
| Multi-generational baseball surname | 35 |
| Multi-gold speedskater Johann ___ Koss | 38 |
| Multi-Grammy-winning gospel singer | 34 |
| Multi-hyphenated Small Faces hit? | 33 |
| Multi-masted Mediterranean vessel | 33 |
| Multi-octave old school crooner Jackie | 38 |
| Multi-purpose product's benefits | 36 |
| Multi-state area for marlin fishing | 35 |
| Multi-___ (doing things simultaneously) | 39 |
| Multicolored, ball-shaped cereal | 32 |
| Multicountry union using the same currency | 42 |
| Multigenerational baseball surname | 34 |
| Multiheaded beast slain by Hercules | 35 |
| Multiheaded serpent slain by Hercules | 37 |
| Multilingual broadcaster since 1942: Abbr. | 42 |
| Multimillion-selling band from Australia | 40 |
| Multimillionaire expatriate, perhaps | 36 |
| Multinational currency with a common reverse side | 49 |
| Multinational group headquartered in D.C. | 41 |
| Multiplatinum Melissa Etheridge album of 1993 | 45 |
| Multiplayer card game with elements of solitaire | 48 |
| Multiple 2003 Grammy winner Jones | 33 |
| Multiple choice choices, perhaps | 32 |
| Multiple choice options, perhaps | 32 |
| Multiple Emmy winner for "Nick News" | 46 |
| Multiple Grammy-winning violinist | 33 |
| Multiple passport holder's status | 37 |
| Multiple-choice question choice, perhaps | 40 |
| Multiple-company building, to Brits | 35 |
| Multiple-unit complex, for short | 32 |
| Multiplex owner's note to self? | 35 |