| Upstairs neighbor of Ralph and Alice | 36 |
| Upstairs staff | 14 |
| Upstairs storage space | 22 |
| Upstairs storeroom | 18 |
| Upstairs window | 15 |
| Upstanding | 10 |
| Upstanding Chinese feature? | 27 |
| Upstanding guy | 14 |
| Upstanding music? | 17 |
| Upstanding one? | 15 |
| UPSTANDING? | 11 |
| Upstart | 7 |
| Upstart business, casually | 26 |
| Upstart who makes insolent comments | 35 |
| Upstarts | 8 |
| Upstate N. Y. city | 18 |
| Upstate N. Y. county | 20 |
| Upstate N. Y. town | 18 |
| Upstate N. Y. village | 21 |
| Upstate N.Y. campus | 19 |
| Upstate N.Y. city | 17 |
| Upstate N.Y. college | 20 |
| Upstate N.Y. lake | 17 |
| Upstate N.Y. lake group | 23 |
| Upstate N.Y. resort | 19 |
| Upstate N.Y. resort area | 24 |
| Upstate N.Y. sch. | 17 |
| Upstate N.Y. school | 19 |
| Upstate N.Y. town | 17 |
| Upstate New York city | 21 |
| Upstate New York city and spa | 29 |
| Upstate New York city famous for silverware | 43 |
| Upstate New York county | 23 |
| Upstate New York natives | 24 |
| Upstate New York prison | 23 |
| Upstate New York spa | 20 |
| Upstate New York town where I.B.M. was founded | 46 |
| Upstate New York vacation spot | 30 |
| Upstate New York's ___ Canal | 32 |
| Upstate New York's ___ Lake | 31 |
| Upstate New Yorker | 18 |
| Upstate NY city that calls itself the "Lake Trout Capital of the World" | 81 |
| Upstream swimmer | 16 |
| Upsurge | 7 |
| Upsurge in activity | 19 |
| Upsurge in business due to the Broncos? | 39 |
| Upsweep, e.g. | 13 |
| Upswept hairstyle | 17 |
| Upswing | 7 |
| Upswing (abbr.) | 15 |
| Upswing on a chart | 18 |
| Uptempo | 7 |
| Uptempo coda | 12 |
| Upthrusts | 9 |
| Uptick | 6 |
| Upticks | 7 |
| Uptight | 7 |
| Uptight accountant of "The Office" | 44 |
| Uptight motion of the hands | 27 |
| Uptight person | 14 |
| Uptight sort | 12 |
| Uptight state | 13 |
| Uptight type | 12 |
| Uptight, after Freud | 20 |
| Uptight, informally | 19 |
| Uptight, outside polite company | 31 |
| Uptight, slangily | 17 |
| Uptightness | 11 |
| Upton Sinclair masterwork | 25 |
| Upton Sinclair novel | 20 |
| Upton Sinclair novel on which "There Will Be Blood" is based | 70 |
| Upton Sinclair novel that inspired "There Will Be Blood" | 66 |
| Upton Sinclair novel that was the inspiration for "There Will Be Blood" | 81 |
| Upton Sinclair subject | 22 |
| Upton Sinclair title from Matthew | 33 |
| Upton Sinclair's Budd | 25 |
| Upton Sinclair's Mr. Budd | 29 |
| Upton who was the cover girl on SI's 2012 Swimsuit Issue | 60 |
| Upton who wrote "Oil!" | 32 |
| Uptown | 6 |
| Uptown ballroom or Thameside hotel | 34 |
| Uptown blowout | 14 |
| Uptown cracker topper | 21 |
| Uptown cracker-topper | 21 |
| Uptown dir. in N.Y.C. | 21 |
| Uptown dir. in NYC | 18 |
| Uptown Japanese-German eatery? | 30 |
| Uptown shindig | 14 |
| Uptown's dir. in N.Y.C. | 27 |
| Uptown's dir. in New York City | 34 |
| Uptown, in NYC | 14 |
| Upturn | 6 |
| Upturn, in Wall St. parlance | 28 |
| Upturned | 8 |
| Upturned mug? | 13 |
| Upturned, as a box | 18 |
| Upturned, as a carton | 21 |
| Upturned, as a crate | 20 |
| Upvotes | 7 |
| Upward | 6 |