| Big inits. in defense contracting | 33 |
| Big inits. in cellular technology | 33 |
| Big initials on Mother's Day | 32 |
| Big initials in nutritional supplements | 39 |
| Big initials in industrial music | 32 |
| Big initials in conspiracy theories | 35 |
| Big initials in comedy syndication | 34 |
| Big initials among camping enthusiasts | 38 |
| Big Indonesian tourist destination | 34 |
| Big house that's not as big? | 32 |
| Big hit for Bobby Day, back in the day | 38 |
| Big Head Todd : "___ Song" | 36 |
| Big Head Todd "Ann ___ Grandfather" | 45 |
| Big games for the Yanks or Sox, perhaps | 39 |
| Big find at an archaeological dig | 33 |
| Big financial setback, figuratively | 35 |
| Big financial management co. on the NYSE | 40 |
| Big fans of a public prosecutor? | 32 |
| Big fan of Captain Kirk and his crew | 36 |
| Big fan of "Gilligan's Island"? | 45 |
| Big exporter of coconut cream and coconut oil | 45 |
| Big expense in today's filmmaking | 37 |
| Big events in the corporate world | 33 |
| Big employer of inspectors: Abbr. | 33 |
| Big electronics defense contractor | 34 |
| Big East Conference team, for short | 35 |
| Big drinking night, stop #6 (home at last) | 42 |
| Big drinking night, stop #5 (night club) | 40 |
| Big drinking night, stop #4 (college bar) | 41 |
| Big drinking night, stop #3 (tapas bar) | 39 |
| Big drinking night, stop #2 (southwestern bar) | 46 |
| Big drinking night, stop #1 (happy hour) | 40 |
| Big drinker's "secret" | 36 |
| Big dot-com headquartered in San Jose | 37 |
| Big dog: ___ Music Entertainment | 32 |
| Big Declaration of Independence signature | 41 |
| Big Daddy player on 1950s Broadway | 34 |
| Big corporation in copper alloys | 32 |
| Big corp. in the aerospace industry | 35 |
| Big conflict of the 1910s, briefly | 34 |
| Big company located in Times Square | 35 |
| Big cluster of tildes and cedillas? | 35 |
| Big city nearest the Golden Spike | 33 |
| Big city mayor-turned-U.S. senator | 34 |
| Big chunks of concrete or marble | 32 |
| Big chunk of Christmas sales nowadays | 37 |
| Big chunk of a drug company's budget | 40 |
| Big cheese, in more ways than one | 33 |
| Big cheese linked with Big Macs? | 32 |
| Big cheese following the East Run (6) | 37 |
| Big cheese associated with Big Macs? | 36 |
| Big celebration for a high schooler | 35 |
| Big cat appendages for the ages? | 32 |
| Big bulldozer company, for short | 32 |
| Big budget item for "Avatar," briefly | 47 |
| Big Brother's eyeballs, perhaps? | 36 |
| Big Brother's "1984" superstate | 45 |
| Big break for the Catholic church? | 34 |
| Big brand of writing instruments | 32 |
| Big boom maker in 1952, for short | 33 |
| Big Board's Big Brother: Abbr. | 34 |
| Big Board's "big brother" | 39 |
| Big blasts from the past, briefly | 33 |
| Big Bird's mammoth friend, familiarly | 41 |
| Big bird whose chicks are nurtured by the male | 46 |
| Big bird that can't take wing | 33 |
| Big Bend National Park lies along it | 36 |
| Big Ben's setting, for short | 32 |
| Big bash at the community garden? | 33 |
| Big bank held by this puzzle's long answers | 47 |
| Big bang, and it's no theory | 32 |
| Big bang maker, and it's no theory | 38 |
| Big attraction for bargain hunters | 34 |
| Big attraction at the train show? | 33 |
| Big attraction at a natural history museum, maybe | 49 |
| Big attraction at a museum, maybe | 33 |
| Big area of philanthropy, with "the" | 46 |
| Big architectural representation? | 33 |
| Big Apple-bound luggage tag code | 32 |
| Big Apple's favorite bread spread? | 38 |
| Big Apple's 30 Rock occupant | 32 |
| Big Apple's "bravest," for short | 46 |
| Big Apple subway, with "the" | 38 |
| Big Apple subway stop, for short | 32 |
| Big Apple subway line, with "the" | 43 |
| Big Apple sch. whose logo is a torch | 36 |
| Big Apple residents, in headlines | 33 |
| Big Apple paper that ran the first crossword | 44 |
| Big Apple neighborhood west of the East Village | 47 |
| Big Apple neighborhood next to the Bowery | 41 |
| Big Apple neighborhood near the Bowery | 38 |
| Big Apple neighborhood near Greenwich Village | 45 |
| Big Apple museum, with "the" | 38 |
| Big Apple museum, for short, with "the" | 49 |
| Big Apple enforcers, for short (4) | 34 |
| Big Apple cop who's looking to bust Popeye? | 47 |
| Big Apple campus at Washington Sq. | 34 |
| Big Apple attraction, with "the" | 42 |
| Big Apple attraction (with "The") | 43 |
| Big Apple artery, with "the" | 38 |