| Big ___ (André 3000's partner) | 37 |
| Big ___ (André 3000's Outkast partner) | 45 |
| Big ___ ("South Park" character) | 42 |
| Big __: Red Sox slugger's nickname | 38 |
| Big __: nickname for LPGA great JoAnne Carner | 45 |
| Big __: baseball's David Ortiz | 34 |
| Big wrigglers allied to fight off robins? | 41 |
| Big winner in 1937 (with "The") | 41 |
| Big wad in exchange for a C-note | 32 |
| Big tournaments for university teams, informally | 48 |
| Big topic in "An Inconvenient Truth" | 46 |
| Big Time Rush "No ___" | 32 |
| Big Three conference site of 1945 | 33 |
| Big Ten football powerhouse, for short | 38 |
| Big surprise in an Easter basket? | 33 |
| Big supplier to Japanese restaurants | 36 |
| Big supplier of health insurance | 32 |
| Big Super Bowl advertiser, traditionally | 40 |
| Big studio release, in the army? | 32 |
| Big step for a pilot-in-training | 32 |
| Big splash maker of the '60s | 32 |
| Big Southern department store chain | 35 |
| Big source of coll. scholarships | 32 |
| Big solos during death scenes, often | 36 |
| Big soda ___ (NYC public health initiative) | 43 |
| Big sister and dance partner of Fred Astaire | 44 |
| Big shot overseeing metamorphoses? | 34 |
| Big shot in the flexible straw industry? | 40 |
| Big shot in charge of locksmiths? | 33 |
| Big shot after making a big shot, maybe: Abbr. | 46 |
| Big shoe specification in Libya? | 32 |
| Big shock wave producer, briefly | 32 |
| Big section of Bartlett's: Abbr. | 36 |
| Big season at Toys"R"Us | 33 |
| Big season at Toys "R" Us | 35 |
| Big scorer alongside Yao, to fans | 33 |
| Big salmon order for a security firm? | 37 |
| Big retailer of home accessories | 32 |
| Big Red Machine shortstop Concepcion | 36 |
| Big recording artists' awards? | 34 |
| Big push to collect singles bar come-ons? | 41 |
| Big purveyor of language lessons | 32 |
| Big publisher in science fiction | 32 |
| Big production company in 1950s-'60s TV | 43 |
| Big prize on "The Price Is Right" | 43 |
| Big presence in many small towns | 32 |
| Big portion of the Mongol Empire | 32 |
| Big piece in a corner office, perhaps | 37 |
| Big picture from the photo lab (abbr.) | 38 |
| Big part of the Sicilian scenery | 32 |
| Big part of many a family budget | 32 |
| Big part of an Obama caricature? | 32 |
| Big part of a trucker's budget | 34 |
| Big Papi's team, on scoreboards | 35 |
| Big newsstand seller for some magazines | 39 |
| Big newspapers and magazines, etc. | 34 |
| Big newspaper company, informally | 33 |
| Big news in the 40's and 50's | 37 |
| Big news for a starting business: Abbr. | 39 |
| Big New York contract signer of 2007, to fans | 45 |
| Big natural history museum attraction | 37 |
| Big name in world domination via shitty futons | 46 |
| Big name in Worcestershire sauce | 32 |
| Big name in women's apparel since 1949 | 42 |
| Big name in weight-loss supplements | 35 |
| Big name in Web-based correspondence | 36 |
| Big name in unnervingly militaristic toys | 41 |
| Big name in trip planning for young people | 42 |
| Big name in Tinseltown tittle-tattle | 36 |
| Big name in the women's suffrage movement | 45 |
| Big name in the study of gravity | 32 |
| Big name in the newspaper business | 34 |
| Big name in the frozen food aisle | 33 |
| Big name in the fast food business | 34 |
| Big name in the diamond business? | 33 |
| Big name in the condiment business | 34 |
| Big name in Thanksgiving parades | 32 |
| Big name in television production | 33 |
| Big name in talk shows (#1 on the list) | 39 |
| Big name in sweaty soap operas for men | 38 |
| Big name in supplemental insurance | 34 |
| Big name in student encyclopedias | 33 |
| Big name in spreadsheet software | 32 |
| Big name in sports trading cards | 32 |
| Big name in small kitchen appliances | 36 |
| Big name in satellite broadcasting | 34 |
| Big name in San Francisco politics | 34 |
| Big name in reproductive technology | 35 |
| Big name in Renaissance patronage | 33 |
| Big name in publishing [up to 118 pounds] | 41 |
| Big name in pianos and motorcycles | 34 |
| Big name in paperback publishing | 32 |
| Big name in outdoor equipment, for short | 40 |
| Big name in online restaurant reviews | 37 |
| Big name in online merchandising | 32 |
| Big name in online financial services | 37 |
| Big name in online correspondence | 33 |
| Big name in online celebrity gossip | 35 |
| Big name in old rock 'n' roll radio | 43 |
| Big name in nutrient applicators | 32 |