| A smoker may flick it off | 25 |
| A smokeless tobacco | 19 |
| A smoked salmon | 15 |
| A Smith | 7 |
| A smidgen | 9 |
| A smattering of | 15 |
| A smash might smash into it | 27 |
| A smartypants may have a big one | 32 |
| A smaller portion | 17 |
| A smaller number | 16 |
| A smaller amount of | 19 |
| A smaller amount | 16 |
| A small, freshwater fish | 24 |
| A small twig | 12 |
| A small Tom | 11 |
| A small price to pay | 20 |
| A small one makes extinction more likely | 40 |
| A small one is white | 20 |
| A small one helps the indecisive | 32 |
| A small goodbye? | 16 |
| A small finch | 13 |
| A small ending | 14 |
| A small drink of liquor | 23 |
| A small dose: Abbr. | 19 |
| A small dog, for short | 22 |
| A small dog | 11 |
| A small diner might be part of it | 33 |
| A small ante | 12 |
| A small amount | 14 |
| A smack of the lips | 19 |
| A slowpoke may be asked to pick it up | 37 |
| A sloth of _____ | 16 |
| A sloth | 7 |
| A slot machine has one | 22 |
| A sloop has one | 15 |
| A slob makes one | 16 |
| A slipcover might cover it | 26 |
| A slick, with or without pics | 29 |
| A slew | 6 |
| A sleigh puller | 15 |
| A sleeve covers it | 18 |
| A sleeper hit may be on it | 26 |
| A slayer of Ymir | 16 |
| A slave, not waves | 18 |
| A slave, not a wave | 19 |
| A slave to opera? | 17 |
| A slave to crosswords? | 22 |
| A slave of opera | 16 |
| A Slaughter | 11 |
| A slap may invite one | 21 |
| A Skywalker | 11 |
| A sky color | 11 |
| A skulk of _____ | 16 |
| A skin layer | 12 |
| A skein of _____ | 16 |
| A size too small, maybe | 23 |
| A size too small | 16 |
| A size smaller, say | 19 |
| A size of paper | 15 |
| A size of larceny | 17 |
| A size | 6 |
| A sixth-day creation | 20 |
| A sixth-century Dacia settler | 29 |
| A sixth of the way through the hour | 35 |
| A Sitwell | 9 |
| A sitter employs one | 20 |
| A site of the Normandy Invasion | 31 |
| A sister-in-law of Jacob | 24 |
| A sister-in-law of Albany | 25 |
| A sister of Zsa Zsa | 19 |
| A sister of Thalia | 18 |
| A sister of Terpsichore | 23 |
| A sister of Semele | 18 |
| A sister of Pygmalion | 21 |
| A sister of Peter Rabbit | 24 |
| A sister of Melpomene | 21 |
| A sister of Jupiter | 19 |
| A sister of John Boy | 20 |
| A sister of Goneril | 19 |
| A sister of Europa | 18 |
| A sister of Eunomia | 19 |
| A sister of Demeter | 19 |
| A sister of Cordelia | 20 |
| A sister of Clio | 16 |
| A sister of Calliope | 20 |
| A sister of Ares | 16 |
| A Sis or a Bro | 14 |
| A sir | 5 |
| A Siouan | 8 |
| A sinsation | 11 |
| A single, in Stuttgart | 22 |
| A single time | 13 |
| A single stroke under par | 25 |
| A single stroke | 15 |
| A single occasion | 17 |
| A single might get you one: Abbr. | 33 |
| A single might get you one | 26 |
| A single may go this | 20 |
| A single may get you one, briefly | 33 |
| A single is one | 15 |