| A sport of royals | 17 |
| A sport may grab it | 19 |
| A spore is at its core | 22 |
| A sponge might have a big one | 29 |
| A sponge may get this | 21 |
| A splitting, as of atoms | 24 |
| A spiritual | 11 |
| A spirited steed | 16 |
| A spirit raiser? | 16 |
| A spirit | 8 |
| A spire is part of one | 22 |
| A spiral | 8 |
| A spinner in space | 18 |
| A Spinks | 8 |
| A Spice Girl | 12 |
| A spice | 7 |
| A sphere lacks them | 19 |
| A speedster may do it | 21 |
| A speech affliction | 19 |
| A spectral type | 15 |
| A speck with wings | 18 |
| A species constituting a genus | 30 |
| A special sense | 15 |
| A special número | 19 |
| A special happening | 19 |
| A special glow | 14 |
| A special | 9 |
| A speaker might make it | 23 |
| A spat covers it | 16 |
| A sPArkling brightness | 22 |
| A spare one might be lost on a diet | 35 |
| A spar | 6 |
| A Spanish queen and namesakes | 29 |
| A Spanish queen | 15 |
| A Spanish liqueur | 17 |
| A Spanish crowd? | 16 |
| A Spanish 21 deck has none | 26 |
| A Spaniard's home is his ___ | 32 |
| A span of _____ | 15 |
| A spade, e.g. | 13 |
| A space case? | 13 |
| A space between objects or points | 33 |
| A soybean state | 15 |
| A Soviet republic | 17 |
| A Soviet adm. division | 22 |
| A Southern sodbuster ___ | 24 |
| A southern constellation | 24 |
| A Southern belle's esteem for her man? | 42 |
| A Southeast Asian | 17 |
| A south-of-the-border assent | 28 |
| A South Asian capital | 21 |
| A South African capital | 23 |
| A South African | 15 |
| A source of wine or strings for musicians | 41 |
| A source of the Mississippi | 27 |
| A source of tar | 15 |
| A source of tapioca | 19 |
| A source of sugar and syrup | 27 |
| A source of sugar | 17 |
| A source of strength | 20 |
| A source of starch | 18 |
| A source of soft wood | 21 |
| A source of rubber | 18 |
| A source of roe | 15 |
| A source of resin | 17 |
| A source of potassium | 21 |
| A source of oil and flour | 25 |
| A source of oil | 15 |
| A source of mother-of-pearl | 27 |
| A source of mistakes | 20 |
| A source of light | 17 |
| A source of iron | 16 |
| A source of inks and paints | 27 |
| A source of hope | 16 |
| A source of grease | 18 |
| A source of golden fall leaves | 30 |
| A source of cinnamon | 20 |
| A source of caviar | 18 |
| A source of bran | 16 |
| A source of aluminum | 20 |
| A source | 8 |
| A soup basis | 12 |
| A soup base | 11 |
| A sounding together | 19 |
| A sound of relief | 17 |
| A sound of music | 16 |
| A sound from the tower | 22 |
| A sound | 7 |
| A sot he's not | 18 |
| A Sorvino | 9 |
| A sorry state | 13 |
| A sorry lot | 11 |
| A sore loser he isn't | 25 |
| A Sorbonne student | 18 |
| A soprano one has short strings | 31 |
| A soprano may hit it | 20 |
| A soprano can hit it | 20 |
| A sophomore or a junior, e.g. | 29 |
| A song of praise | 16 |
| A song of 1889 | 14 |