| One coulomb per second | 22 |
| One could make sin thin | 23 |
| One could give you a check | 26 |
| One could cost you your queen | 29 |
| One could be on a crib sheet? | 29 |
| One corner in Monopoly | 22 |
| One controlling drones | 22 |
| One contending successfully | 27 |
| One contacted by an executor | 28 |
| One Constantinople ruler | 24 |
| One considering a proposal | 26 |
| One conquered by Pizarro | 24 |
| One connected with: Suffx | 25 |
| One connected with: Suffix | 26 |
| One conferring honor upon | 25 |
| One conditionally freed | 23 |
| One concerned with the nose | 27 |
| One concerned with pitches | 26 |
| One concerned with lines | 24 |
| One concerned with handicaps | 28 |
| One concerned with figures? | 27 |
| One concerned with feet | 23 |
| One concerned with el niño | 29 |
| One concerned with duds? | 24 |
| One concerned with co. money | 28 |
| One concerned with clemency | 27 |
| One concerned with classes | 26 |
| One concerned with bouquets | 27 |
| One concerned with blocking | 27 |
| One concerned with bites | 24 |
| One concerned about wrinkles? | 29 |
| One concerned about charges | 27 |
| One concern of the E.P.A. | 25 |
| One concern of an insurer | 25 |
| One concern of a teacher | 24 |
| One concern of a skipper | 24 |
| One concern of a proofreader | 28 |
| One concern of a grammarian | 27 |
| One concern of a derby bettor | 29 |
| One completes a monument | 24 |
| One completely lacking morals | 29 |
| One committing grave crimes? | 28 |
| One commemorative feast | 23 |
| One coming out, briefly | 23 |
| One coming out of its shell? | 28 |
| One coming down the aisle? | 26 |
| One color of the rainbow | 24 |
| One color in the French flag | 28 |
| One club, two hearts, etc. | 26 |
| One clearing dead leaves | 24 |
| One clapping at a circus? | 25 |
| One choosing a sweater, e.g.? | 29 |
| One cheered in Baltimore | 24 |
| One checking things out | 23 |
| One checking crossings | 22 |
| One cheating on another, e.g. | 29 |
| One charring something | 22 |
| One chained to a desk, say | 26 |
| One chained to a counter | 24 |
| One cause of trembling | 22 |
| One cause of heavy breathing | 28 |
| One cause of food poisoning | 27 |
| One cause of deforestation | 26 |
| One cause of daytime fatigue | 28 |
| One cause of corruption | 23 |
| One cause of blackouts | 22 |
| One cause of a close shave | 26 |
| One caught off base, perhaps | 28 |
| One caught in the headlights | 28 |
| One caught in a police sting | 28 |
| One caught by border patrol | 27 |
| One catching some z's | 25 |
| One catching some waves? | 24 |
| One catching a ram's eye | 28 |
| One catching a lot of waves | 27 |
| One casting aspersions | 22 |
| One cast out of paradise | 24 |
| One carrying on a trade | 23 |
| One carrying off carrion | 24 |
| One carrying handcuffs | 22 |
| One carrying dust, maybe | 24 |
| One carrying a back pack | 24 |
| One carried Sinbad to safety | 28 |
| One captain of the Enterprise | 29 |
| One Capp of the comics | 22 |
| One can stand to lose it | 24 |
| One can stake it or file it | 27 |
| One can be shown to you | 23 |
| One can be loose or tight | 25 |
| One can be called on it | 23 |
| One can be a whole lot | 22 |
| One calling the shots? | 22 |
| One calling the kettle black | 28 |
| One calling technical support | 29 |
| One calling strikes and balls | 29 |
| One calling at peak times? | 26 |
| One called upon to talk? | 24 |
| One called upon to decide | 25 |
| One called to the bar (abbr.) | 29 |
| One by one the klutz _____ | 26 |