| Maj. metropolis of the Show-Me State | 36 |
| Maj. Winchester portrayer on "MASH" | 45 |
| Maj. with credits for studying credit | 37 |
| Majestic animal at the Grand Canyon | 35 |
| Major Adams of "Wagon Train" and others | 49 |
| Major African humanitarian concern of the 2000s | 47 |
| Major ancient construction project | 34 |
| Major artery through San Antonio | 32 |
| Major Baroque composer's monogram | 37 |
| Major Baroque composer's signature | 38 |
| Major brand in heating and air conditioning | 43 |
| Major Canadian short-story writer | 33 |
| Major Côte d'Ivoire export | 33 |
| Major Chicago tourist attraction | 32 |
| Major chunk of Earth's surface | 34 |
| Major city of southwest Colombia | 32 |
| Major city off the coast of China | 33 |
| Major college football's winningest coach | 45 |
| Major company in metallic products | 34 |
| Major component of kidney stones | 32 |
| Major component of Saturn's rings | 37 |
| Major component of the euro symbol | 34 |
| Major country with the longest life expectancy | 46 |
| Major digital satellite service provider | 40 |
| Major division of geological time | 33 |
| Major divisions of geological time | 34 |
| Major export from the islets of Langerhans | 42 |
| Major export of Albania and South Africa | 40 |
| Major export of Brazil and Australia | 36 |
| Major exporter of handmade carpets | 34 |
| Major factor in Korean independence | 35 |
| Major figure in "Paradise Lost" | 41 |
| Major French publisher of reference works | 41 |
| Major German river, to a Frenchman | 34 |
| Major gold-mining area, with "the" | 44 |
| Major govt.-owned power producer | 32 |
| Major highway from Fla. to Calif. | 33 |
| Major Hoople's "drat" | 35 |
| Major Hoople's "whoops" | 37 |
| Major Hoople's exclamation, in the comics | 45 |
| Major Hoople's outburst, in old comics | 42 |
| Major industrial center near Manchester | 39 |
| Major influence in '60s music | 33 |
| Major Internet service provider, for short | 42 |
| Major irritant for American colonists | 37 |
| Major League Baseball commissioner | 34 |
| Major League Baseball commissioner Bud | 38 |
| Major League Baseball family name | 33 |
| Major League Baseball's oldest rookie ever | 46 |
| Major League player before moving to S.F. | 41 |
| Major leaguer in orange and black | 33 |
| Major leaguer or golf instructor | 32 |
| Major leaguer who played in parts of five decades | 49 |
| Major leagues, in baseball lingo | 32 |
| Major leagues, in baseball slang | 32 |
| Major leagues, slangily, with "the" | 45 |
| Major lobbyist against generic drugs | 36 |
| Major Mexican drug cartel, with "los" | 47 |
| Major mix-up in the margarine case? | 35 |
| Major movie on a studio's schedule | 38 |
| Major New York-to-Tennessee route | 33 |
| Major of many a poli sci student | 32 |
| Major org. representing entertainers and athletes | 49 |
| Major part of sumo wrestlin'? | 33 |
| Major piece of cribbage equipment | 33 |
| Major player on '70s and '80s TV | 40 |
| Major portion of oneÂ’s grade, often | 39 |
| Major publisher of romance novels | 33 |
| Major purchaser of McCain ads: Abbr. | 36 |
| Major rd. in Philly or San Francisco | 36 |
| Major recipient of TARP money, which it paid back | 49 |
| Major responsibility for a parent? | 34 |
| Major river to the Mediterranean | 32 |
| Major Russian ballet company, familiarly | 40 |
| Major San Francisco industry, briefly | 37 |
| Major scale in which B is the only natural | 42 |
| Major scale that has C as the seventh note | 42 |
| Major scale that has F as the third note | 40 |
| Major source of the narcotic qat | 32 |
| Major stress factor, it's said | 34 |
| Major tournaments for clergymen? | 32 |
| Major U.S. Spanish-language daily | 33 |
| Major U.S./Mexico border crossing | 33 |
| Major W.W. II Japanese base on New Guinea | 41 |
| Major waterway of Eastern Europe | 32 |
| Major Winchester portrayer David Ogden | 38 |
| Major work from the Latin for "work" | 46 |
| Major-league career leader in at bats | 37 |
| Major-league team member through 2004 | 37 |
| Major-leaguer from Osaka who threw two no-hitters | 49 |
| Major-leaguer with three 60+ home run seasons | 45 |
| Majority of a crowd at a Jonas Brothers concert | 47 |
| Majority of Oprah's audience | 32 |
| Majority of U.S. governors, as of 2009: Abbr. | 45 |
| Majors of "The Six Million Dollar Man" | 48 |
| Make ''all gone'' | 33 |
| Make -- for (try to win at auction) | 35 |
| Make a baseball player sit out the game? | 40 |
| Make a beeline in the direction of | 34 |
| Make a call to see someone nowadays? | 36 |