| Two-man competition | 19 |
| Two-man band? | 13 |
| Two-liter bottle contents, sometimes | 36 |
| Two-liter bottle contents | 25 |
| Two-line verse | 14 |
| Two-letter sequence | 19 |
| Two-letter combinations | 23 |
| Two-letter combination | 22 |
| Two-legged zebra | 16 |
| Two-legged wolves' looks | 28 |
| Two-legged wolf's look | 26 |
| Two-legged support | 18 |
| Two-legged stand | 16 |
| Two-legged sponge | 17 |
| Two-legged salamander | 21 |
| Two-legged meat source | 22 |
| Two-legged measuring instruments | 32 |
| Two-legged measuring device | 27 |
| Two-legged measurer | 19 |
| Two-legged livestock | 20 |
| Two-legged creature | 19 |
| Two-legged | 10 |
| Two-layered gem | 15 |
| Two-layered candy | 17 |
| Two-lanes-into-one highway sign | 31 |
| Two-lane topper, often | 22 |
| Two-lane topper | 15 |
| Two-lane highway, maybe | 23 |
| Two-L llama | 11 |
| Two-l creatures | 15 |
| Two-kind link | 13 |
| Two-kind connector | 18 |
| Two-jawed device | 16 |
| Two-inch stripe wearer: Abbr. | 29 |
| Two-inch putt, e.g. | 19 |
| Two-inch nail | 13 |
| Two-in-one creatures? | 21 |
| Two-in-one | 10 |
| Two-humped camel | 16 |
| Two-hulled vessel, for short | 28 |
| Two-hulled craft | 16 |
| Two-hued sea predator | 21 |
| Two-hr. warning for Cinderella? | 31 |
| Two-horse wager | 15 |
| Two-horse bet | 13 |
| Two-holed feature | 17 |
| Two-headed, three-armed President in the books referenced in this puzzle's theme | 84 |
| Two-headed lady exhibit, e.g. | 29 |
| Two-headed fastener | 19 |
| Two-headed drumsticks | 21 |
| Two-headed calf, for one | 24 |
| Two-hanky film | 14 |
| Two-handled Greek vase | 22 |
| Two-handled cooking vessels | 27 |
| Two-handed sandwich | 19 |
| Two-handed pinochle | 19 |
| Two-handed lunches | 18 |
| Two-handed lunch orders | 23 |
| Two-handed log cutter | 21 |
| Two-handed hoop attempts | 24 |
| Two-handed hammer | 17 |
| Two-handed gesture used for ironic effect | 41 |
| Two-handed game | 15 |
| Two-handed carpenter's tool | 31 |
| Two-handed card game | 20 |
| Two-grade system | 16 |
| Two-generation name in Indiana politics | 39 |
| Two-generation MLB family name | 30 |
| Two-generation groups | 21 |
| Two-generation diamond name | 27 |
| Two-front, as a Coast Guard rescue | 34 |
| Two-for-one? | 12 |
| Two-for-one, for one | 20 |
| Two-for-one, e.g. | 17 |
| Two-for-one event | 17 |
| Two-for-one deal, say | 21 |
| Two-for-one at a leading dating site? | 37 |
| Two-footers | 11 |
| Two-footer? | 11 |
| Two-footer | 10 |
| Two-footed ones | 15 |
| Two-footed livestock | 20 |
| Two-footed creatures | 20 |
| Two-footed creature | 19 |
| Two-footed animal | 17 |
| Two-footed | 10 |
| Two-foot verse | 14 |
| Two-fold | 8 |
| Two-floor apartment | 19 |
| Two-flat key | 12 |
| Two-fisted sandwich | 19 |
| Two-fisted one | 14 |
| Two-fisted lunch | 16 |
| Two-fisted fellows | 18 |
| Two-fisted | 10 |
| Two-finger sign | 15 |
| Two-finger salute | 17 |
| Two-finger gesture | 18 |
| Two-film show | 13 |
| Two-figure sculpture | 20 |