| Lorre's role in "Casablanca" | 42 |
| Los Alamos experiments, in headlines | 36 |
| Los Alamos National Laboratory locale | 37 |
| Los Alamos test subjects, informally | 36 |
| Los Angeles and San Francisco, e.g. | 35 |
| Los Angeles art and design school | 33 |
| Los Angeles attraction (with "the") | 45 |
| Los Angeles attraction, with "the" | 44 |
| Los Angeles bay named for an apostle | 36 |
| Los Angeles County's ___ Beach | 34 |
| Los Angeles district attorney Garcetti | 38 |
| Los Angeles district near Sherman Oaks | 38 |
| Los Angeles indoor football player | 34 |
| Los Angeles locale of a Lloyd Webber musical | 44 |
| Los Angeles museum, with "the" | 40 |
| Los Angeles Opera director beginning in 2000 | 44 |
| Los Angeles Philharmonic summer venue | 37 |
| Los Angeles Sparks general manager Penny | 40 |
| Los Angeles suburb named for a goddess of fruit | 47 |
| Los Angeles suburb next to Torrance | 35 |
| Los Angeles's La ___ Tar Pits | 33 |
| Los Angeles's U.S.S. ___ Museum | 35 |
| Los Angeles's ___ College of Art and Design | 47 |
| Los Angeles's ___ Verdes Peninsula | 38 |
| Los Angeles's ___-Sinai Medical Center | 42 |
| Los Angeles-to-San Bernardino direction | 39 |
| Los Del ___ ("Macarena" band) | 39 |
| Los del ___ ("Macarena" duo) | 38 |
| Los __, city near San Luis Obispo | 33 |
| Los ___ ("La Bamba" band) | 35 |
| Los ___ (Manhattan Project lab site) | 36 |
| Los ___ (Manhattan Project site) | 32 |
| Los ___ (seat of Valencia County, New Mexico) | 45 |
| Los ___ de los Muertos (Mexican holiday) | 40 |
| Lose all one's money in gambling | 36 |
| Lose at a dice game (with "out") | 42 |
| Lose eligibility because of being too old | 41 |
| Lose eligibility on a birthday, say | 35 |
| Lose ground, in a Paul Simon song | 33 |
| Lose money on "Jeopardy!" | 35 |
| Lose money on "Jeopardy!," e.g. | 41 |
| Lose on "Concentration"? | 34 |
| Lose one's nerve at the worst possible moment | 49 |
| Lose one's patience with, maybe | 35 |
| Lose one's sense of direction? | 34 |
| Lose one's shirt, in business | 33 |
| Lose personnel, in military-speak | 33 |
| Lose sleep over (with "about") | 40 |
| Lose steam, with "out" | 32 |
| Lose strength in the backstretch | 32 |
| Lose support, as at campaign's end | 38 |
| Lose weight (with "down") | 35 |
| Lose weight, with "down" | 34 |
| Lose your composure, in junior high-speak | 41 |
| Loser at Châlons-sur-Marne in 451 | 36 |
| Loser at the Battle of Châlons, A.D. 451 | 43 |
| Loser in ''Cinderella Man'' | 43 |
| Loser in a 1962 showdown with J.F.K. | 36 |
| Loser in Brown v. Board of Education | 36 |
| Loser in many product comparisons | 33 |
| Loser in the Battle of Bannockburn, 1314 | 40 |
| Loser in the first World Series, 1903 | 37 |
| Loser in the Seven Years' War: Abbr. | 40 |
| Loser of a footrace with Hippomenes | 35 |
| Loser of the "golden apples" race | 43 |
| Loser to "Cabaret" for Best Musical | 45 |
| Loser to Affirmed in all three Triple Crown races | 49 |
| Loser to Al Pacino for Best Actor of 1992 | 41 |
| Loser to Apollo Creed in their first bout | 41 |
| Loser to Audrey for the 1953 Best Actress Oscar | 47 |
| Loser to Björn in the 1976 Wimbledon final | 45 |
| Loser to Bon Homme Richard: 1779 | 32 |
| Loser to Eisenhower: 1952 and 1956 | 34 |
| Loser to Ghana in the 2010 World Cup | 36 |
| Loser to Happy Feet at the 2007 Oscars | 38 |
| Loser to Israel's Barak in 1999 | 35 |
| Loser to Nastase at the 1972 U.S. Open finals | 45 |
| Loser to paper and winner over scissors | 39 |
| Loser to Penn State: 1982 Sugar Bowl | 36 |
| Loser to Sheridan in the Shenandoah Valley | 42 |
| Loser to Sparta in the Peloponnesian War | 40 |
| Losers in the Battle of Horseshoe Bend | 38 |
| Losers of the Battle of Meloria, 1284 | 37 |
| Losers on "The Apprentice"? | 37 |
| Losers to BOS in the 2010 NBA playoffs | 38 |
| Losers to the 49ers in Super Bowl XXIII | 39 |
| Losers to the Rangers for the 1994 Stanley Cup | 46 |
| Losers to the Yankees in the 1998 Series | 40 |
| Losers, in an anti-drug campaign | 32 |
| Loses control on a snowy road, say | 34 |
| Loses energy, with "down" | 35 |
| Loses focus, with "out" | 33 |
| Loses ignominiously, on a game show | 35 |
| Loses one's footing at the car wash? | 40 |
| Loses weight (with "down") | 36 |
| Loses weight, with "down" | 35 |
| Loses what was originally put down? | 35 |
| Loses, in a way, with "down" | 38 |
| Losing a record deal, for example | 33 |
| Losing at checkers in a thunderstorm? | 37 |