| A skulk of _____ | 16 |
| A sky color | 11 |
| A Skywalker | 11 |
| A slap may invite one | 21 |
| A Slaughter | 11 |
| A slave of opera | 16 |
| A slave to crosswords? | 22 |
| A slave to opera? | 17 |
| A slave, not a wave | 19 |
| A slave, not waves | 18 |
| A slayer of Ymir | 16 |
| A sleeper hit may be on it | 26 |
| A sleeve covers it | 18 |
| A sleigh puller | 15 |
| A slew | 6 |
| A slick, with or without pics | 29 |
| A slipcover might cover it | 26 |
| A slob makes one | 16 |
| A sloop has one | 15 |
| A slot machine has one | 22 |
| A sloth | 7 |
| A sloth of _____ | 16 |
| A slowpoke may be asked to pick it up | 37 |
| A smack of the lips | 19 |
| A small amount | 14 |
| A small ante | 12 |
| A small diner might be part of it | 33 |
| A small dog | 11 |
| A small dog, for short | 22 |
| A small dose: Abbr. | 19 |
| A small drink of liquor | 23 |
| A small ending | 14 |
| A small finch | 13 |
| A small goodbye? | 16 |
| A small one helps the indecisive | 32 |
| A small one is white | 20 |
| A small one makes extinction more likely | 40 |
| A small price to pay | 20 |
| A small Tom | 11 |
| A small twig | 12 |
| A small, freshwater fish | 24 |
| A smaller amount | 16 |
| A smaller amount of | 19 |
| A smaller number | 16 |
| A smaller portion | 17 |
| A smartypants may have a big one | 32 |
| A smash might smash into it | 27 |
| A smattering of | 15 |
| A smidgen | 9 |
| A Smith | 7 |
| A smoked salmon | 15 |
| A smokeless tobacco | 19 |
| A smoker may flick it off | 25 |
| A smoker might bum one | 22 |
| A Smothers brother | 18 |
| A Smurf | 7 |
| A snake charmed her | 19 |
| A snake mackerel | 16 |
| A snake may swallow one whole | 29 |
| A snaky letter? | 15 |
| A snap | 6 |
| A snifter has a short one | 25 |
| A sniggler snares it | 20 |
| A sniggler's a giggler when he snares it | 44 |
| A snooze under a sombrero | 25 |
| A snowflake is one | 18 |
| A soc. sci. | 11 |
| A soccer player | 15 |
| A social | 8 |
| A social gathering | 18 |
| A social grace | 14 |
| A social sci. | 13 |
| A social stratum | 16 |
| A socially correct goose in Boston? | 35 |
| A socially correct goose? | 25 |
| A Society Island | 16 |
| A Socratic dialogue | 19 |
| A sodium carbonate | 18 |
| A soft cheese | 13 |
| A soft drink | 12 |
| A soft drink may have one | 25 |
| A soft place to dance | 21 |
| A soil fertilizer | 17 |
| A solar system "ice giant" | 36 |
| A soldier may swig from it | 26 |
| A soldier might get a medal for it | 34 |
| A soldier working in a mess? | 28 |
| A soldier's gear, for example | 33 |
| A sole might get caught in it | 29 |
| A solid | 7 |
| A solid alcohol | 15 |
| A solid caustic | 15 |
| A solid shaped like a doughnut | 30 |
| A solid-colored billiard ball | 29 |
| A solitary wasp was named after this actress | 44 |
| A solo dinger counts for one | 28 |
| A solo HR earns one | 19 |
| A solo shot gets you one: Abbr. | 31 |
| A somebody | 10 |
| A someday sow | 13 |