| A series of "insurmountable obstacles on the road to imminent disaster," per Tom Stoppard | 99 |
| A series of chirps | 18 |
| A series of curls | 17 |
| A series of disasters | 21 |
| A series of skits | 17 |
| A Serious Man filmmakers | 24 |
| A serious one may be red | 24 |
| A sermon of Buddha | 18 |
| A serous fluid | 14 |
| A servant in "The Taming . . . " | 42 |
| A service break might break one | 31 |
| A service winner | 16 |
| A serving of grog or rum | 24 |
| A Sesame Streeter | 17 |
| A set for ''The White Shadow'' | 46 |
| A set of bks. | 13 |
| A Seton | 7 |
| A setting for "The Student Prince" | 44 |
| A Seven Sisters school | 22 |
| A seven-footer, quite often | 27 |
| A seventh-century date | 22 |
| A seventh-century Irish bishop who became a saint | 49 |
| A Severn feeder | 15 |
| A Sevillian | 11 |
| A sew-and-sew? | 14 |
| A sewer has one | 15 |
| A Sex Pistol | 12 |
| A shade of beige | 16 |
| A shade of blue | 15 |
| A shade of green | 16 |
| A shade of red | 14 |
| A shady group | 13 |
| A shaft | 7 |
| A shake in the grass? | 21 |
| A Shakespeare contemporary | 26 |
| A shaman uses them | 18 |
| A shark may carry one | 21 |
| A shark might give you one | 26 |
| A sharp | 7 |
| A sharp key? | 12 |
| A sharp, by another name | 24 |
| A sharpshooter needs a good one | 31 |
| A Shaw | 6 |
| A Shaw who married a Gardner | 28 |
| A sheep dog | 11 |
| A sheep remark | 14 |
| A sheepdog | 10 |
| A sheik, e.g. | 13 |
| A sheikdom | 10 |
| A sheikhdom | 11 |
| A shelf in a kitchen cabinet? | 29 |
| A shelter | 9 |
| A shepherd shepherds it | 23 |
| A shepherd, originally | 22 |
| A sheriff carries one | 21 |
| A sheriff may be seen in it | 27 |
| A sheriff may round one up | 26 |
| A Sherman Act target | 20 |
| A shift lever changes them | 26 |
| A shiny fabric | 14 |
| A ship deck | 11 |
| A ship from the Middle East, perhaps | 36 |
| A ship may appear on it | 23 |
| A ship remembered | 17 |
| A ship to remember | 18 |
| A ship, to crew members | 23 |
| A shirt tag may tickle it | 25 |
| A shoe may have one | 19 |
| A shoe presses against it | 25 |
| A shogun may tie one on | 23 |
| A shoo-in | 9 |
| A shoot-out, e.g. | 17 |
| A shooter might take it | 23 |
| A shooter takes it off | 22 |
| A shooting star | 15 |
| A shootout might end it | 23 |
| A shopping mall has lots of these | 33 |
| A short amt. of time | 20 |
| A short distance | 16 |
| A short may break one | 21 |
| A short rest, in actors' lingo | 34 |
| A short story, in Sept-Isles | 29 |
| A short, thickset haddock? | 26 |
| A shortening, in more ways than one | 35 |
| A shorthand inventor | 20 |
| A Shoshonean | 12 |
| A shot | 6 |
| A shot in the arm, maybe | 24 |
| A shot in the arm, say | 22 |
| A shot in the dark | 18 |
| A shot is often harmless if it caroms off of one | 48 |
| A shot might indicate it | 24 |
| A show of vanity | 16 |
| A Shriver | 9 |
| A Shropshire ____ | 17 |
| A shutout lowers it | 19 |
| A shuttlecock sails over it | 27 |
| A Siamese twin | 14 |
| A sib | 5 |
| A sib for sis | 13 |