| The shallowest Great Lake | 25 |
| The shaman's poker night spread? | 36 |
| The shame of cities | 19 |
| The shamrock is its symbol | 26 |
| The Shamrock Isle | 17 |
| The Shangri-___ ("Leader of the Pack" group) | 54 |
| The Shangri-___ (1960s pop group) | 33 |
| The Sharks and the Jets, e.g. | 29 |
| The Sharks of Broadway, e.g. | 28 |
| The Sharks, e.g. | 16 |
| The shay's motive power | 27 |
| The Sheik, for one | 18 |
| The sheriff on "The Rifleman" and others | 50 |
| The Shins "___ Needles" | 33 |
| The Shirelles' ''Mama ___'' | 47 |
| The Shirelles' "--- Him on a Sunday" | 50 |
| The Shirelles' "Mama ___" | 39 |
| The shit | 8 |
| The shivers | 11 |
| The shoe department in its flagship store has its own zip code | 62 |
| The shoe __ the other foot | 26 |
| The shopper ___ | 15 |
| The short end | 13 |
| The short-tempered fellow ___ | 29 |
| The shorter you are? | 20 |
| The shortest Beatle | 19 |
| The shortest distances between points | 37 |
| The shortest month? | 19 |
| The shortest of 12: Abbr. | 25 |
| The shortest one has only two verses | 36 |
| The Show Me state | 17 |
| The show's partly completed puzzle (category: hosts) | 56 |
| The shrew in "The Taming of the Shrew" | 48 |
| The Shrew's home | 20 |
| The Shrivers, to Schwarzenegger | 31 |
| The Shroud of Turin and others | 30 |
| The Sickle is in it | 19 |
| The Sierra Club founder | 23 |
| The Sierra Nevada Minarets, e.g. | 32 |
| The Sierras, e.g. | 17 |
| The Sierras, e.g.: Abbr. | 24 |
| The signal with the sound | 25 |
| The signs in the movie "Signs" | 40 |
| The Silence of the ____ | 23 |
| The silent brother | 18 |
| The silent dwarf | 16 |
| The silent Marx | 15 |
| The silent treatment? | 21 |
| The silent type | 15 |
| The silent ___ | 14 |
| The Silk Road Ensemble musician | 31 |
| The Silver Bullet Band leader | 29 |
| The silver screen | 17 |
| The Silver St. | 14 |
| The Silver State | 16 |
| The Silver State (Abbr.) | 24 |
| The Silver State, for short | 27 |
| The Silver State: Abbr. | 23 |
| The simple basics | 17 |
| The Simpson brat | 16 |
| The Simpson kid | 15 |
| The Simpson who once got hooked on crosswords | 45 |
| The Simpsons and Popeye, e.g. | 29 |
| The Simpsons' answer to the Barbie doll | 43 |
| The Simpsons' neighbor | 26 |
| The Simpsons' neighbor Flanders | 35 |
| The Simpsons' neighbor, Flanders | 36 |
| The Simpsons' Snowball II, e.g. | 35 |
| The Simpsons, e.g. | 18 |
| The sin bin | 11 |
| The sincerest of flattery | 25 |
| The Singh-ing golfer | 20 |
| The Singing Cowboy | 18 |
| The singing voice, informally | 29 |
| The single (hyph.) | 18 |
| The sinuses | 11 |
| The situation | 13 |
| The six days of the Creation | 28 |
| The six for a TD | 16 |
| The six of ''Little Nellie Kelly'' | 50 |
| The six of "Little Nellie Kelly" | 42 |
| The six-time champ | 18 |
| The Sixers play in it | 21 |
| The Sixth Amendment prevents trials in it, in most cases | 56 |
| The sixth of Henry VIII | 23 |
| The sixth sense | 15 |
| The Sixties, e.g. | 17 |
| The sixties, for one | 20 |
| The size of ___ (itty-bitty) | 28 |
| The Skagerrak, to the North Sea | 31 |
| The Skatalites' Jackie | 26 |
| The skeptic | 11 |
| The skin is one | 15 |
| The skin is the largest one in humans | 37 |
| The skinny | 10 |
| The Skins Game game | 19 |
| The Skins Game sport | 20 |
| The Skipper's plan, on paper | 32 |
| The skull reminded Hamlet that he ___ | 37 |
| The sky | 7 |