| The One, in "The Matrix" | 34 |
| The ones before us | 18 |
| The ones born in late July | 26 |
| The ones chosen | 15 |
| The ones close by | 17 |
| The ones here | 13 |
| The ones in front of us | 23 |
| The ones mentioned | 18 |
| The ones nearby | 15 |
| The ones not taken | 18 |
| The ones over there | 19 |
| The ones present | 16 |
| The ones right here | 19 |
| The ones right in front of us | 29 |
| The ones that got away? | 23 |
| The ones there | 14 |
| The ones yonder | 15 |
| The Onion: "___ Announces New Version of Magazine Aimed at Adults" | 76 |
| The only "Celebrity Apprentice" participant to appear on a previous "Apprentice" season | 107 |
| The only 1930's boxing champ you need to know for solving crosswords | 72 |
| The only African G20 country: Abbr. | 35 |
| The only author on the Forbes Billionaires list | 47 |
| The only Blues Brother to reappear in "Blues Brothers 2000" | 69 |
| The only British pope | 21 |
| The only chess player you need to know for solving crosswords | 61 |
| The only company authorized to make Monopoly | 44 |
| The only even prime number | 26 |
| The only evil, per Socrates | 27 |
| The only grading letters that appear anywhere in this puzzle (other than the present clue) | 90 |
| The only Guns guitarist | 23 |
| The only horse that beat Man o' War | 39 |
| The only imaginable way for rock to beat scissors? | 50 |
| The only loser in the "Dallas" family? | 48 |
| The only major U.S. city founded by a woman | 43 |
| The only medicine for the miserable, according to Shakespeare | 61 |
| The only movie to be the highest-grossing of the year and still lose money | 74 |
| The only one-syllable state name | 32 |
| The only ones they have to blame? | 33 |
| The only person to have been nominated for an Oscar, a Golden Globe, a Grammy and the Nobel Peace Prize | 103 |
| The only person with the authority to call a strike, for short | 62 |
| The only pieces there are exactly three of in Scrabble | 54 |
| The only player to hit a walk-off home run in a World Series Game 7 | 67 |
| The only recipient of Sports Illustrated's "Sportswoman of the Year" (from 1976) | 94 |
| The only Ron Howard film a crossword solver needs to know | 57 |
| The only royal palace in the U.S. | 33 |
| The only three-letter element | 29 |
| The only U.S. president whose vice president ran against him to succeed him was John .... | 89 |
| The only woman on Time's list of the 20 most influential 20th-century business geniuses | 91 |
| The open | 8 |
| The Open Boat author | 23 |
| The opening of an iris | 22 |
| The opponents | 13 |
| The opportunity to start over | 29 |
| The opposing side | 17 |
| The opposing team | 17 |
| The opposite of a nail-biter | 28 |
| The opposite of failed miserably | 32 |
| The opposite of putting on sale | 31 |
| The opposition | 14 |
| The oppositions | 15 |
| The optimist ... | 16 |
| The optometrist's place? | 28 |
| The optometrist's zero-star review? | 39 |
| The oracle of Apollo, e.g. | 26 |
| The Oracle of ___ (Buffett epithet) | 35 |
| The Oracle of ___ (Warren Buffett sobriquet) | 44 |
| The Orange Bowl is played on it: Abbr. | 38 |
| The orange kind is black | 24 |
| The orange variety is black | 27 |
| The orchestra tunes to one | 26 |
| The orderly universe | 20 |
| The Oregon Trail crossed it | 27 |
| The Oregon Trail? | 17 |
| The Oregon ___ | 14 |
| The Orient | 10 |
| The Orient Express was one | 26 |
| The Orient Express, e.g. | 24 |
| The Orient Express, e.g.: Abbr. | 31 |
| The orig. 13, e.g. | 18 |
| The origin of an invention | 26 |
| The original ''The Office'' network | 51 |
| The original "Damn Yankees" Lola | 42 |
| The original "golden boy"? | 36 |
| The original "It" girl | 32 |
| The original "Slammin' Sammy" | 43 |
| The original decaf | 18 |
| The original Goldfinger? | 24 |
| The original Jefferson Airplane, e.g. | 37 |
| The original Lola, in "Damn Yankees" | 46 |
| The original Miss Saigon | 24 |
| The original Ocean in "Ocean's 11" | 48 |
| The original ones were actors | 29 |
| The original Slammin' Sammy | 31 |
| The original void | 17 |
| The orthopedist ordered a __ | 28 |
| The orthopedist went on stage after a ___ | 41 |
| The Os in Cheerios? | 19 |
| The Oscars and Olympics, say | 28 |
| The Oscars are awarded on it: Abbr. | 35 |
| The Oscars of magazine publishing | 33 |