| The first complete navigation of the Amazon was in search of this | 65 |
| The first Cosby show | 20 |
| The first electric one was used in Paris in the 1870s | 53 |
| The first film it aired was "Gone with the Wind" | 58 |
| The first four-minute mile, e.g.? | 33 |
| The first glossy fabric? | 24 |
| The first H in HRH, perhaps | 27 |
| The first indication that I had one too many last night? | 56 |
| The first installment | 21 |
| The first James Bond film | 25 |
| The first James Bond movie | 26 |
| The First Lady of Song, to fans | 31 |
| The first letter of "cent," e.g. | 42 |
| The first letter of "circle" (but not the fourth) | 59 |
| The first letter of "tsar," in Cyrillic | 49 |
| The first lover | 15 |
| The first man in space | 22 |
| The first man to fly in space twice | 35 |
| The first man, in Maori myth | 28 |
| The first manned Apollo mission | 31 |
| The first martyr, in Islam | 26 |
| The first mes | 13 |
| The first Mr. Shirley Temple | 28 |
| The first Mrs. Arrowsmith | 25 |
| The first Mrs. Copperfield | 26 |
| The first Mrs. Donald Trump | 27 |
| The first Mrs. Richard Wagner | 29 |
| The first Mrs. Soames Forsyte | 29 |
| The first Mrs. Trump | 20 |
| The first Mrs. Woodrow Wilson | 29 |
| The first multimillionaire | 26 |
| The first N in CNN | 18 |
| The first natural number | 24 |
| The first non-British to receive Britain's Dickin Medal for Gallantry was a _____ | 85 |
| The first Norwegian band with a number 1 song in the US | 55 |
| The first O of O-O-O | 20 |
| The first odd prime number | 26 |
| The first of 13: Abbr. | 22 |
| The first of Henry VIII's two Annes | 39 |
| The first of Judy's daughters | 33 |
| The first of Judy's two daughters | 37 |
| The first of many steps | 23 |
| The first of September? | 23 |
| The first of several? | 21 |
| The first of two | 16 |
| The first of Weird Al's 2014 parodies | 41 |
| The first official one was November 11, 1919 | 44 |
| The first one appeared on this date in 1913 | 43 |
| The first one gets you going | 28 |
| The first one opened in Detroit in 1962 | 39 |
| The first one opened on Majorca in 1950 | 39 |
| The first one pointed to? | 25 |
| The first one ruled 1547-84 | 27 |
| The first one was founded in 1824 Eng. to protect carriage horses | 65 |
| The first one was made at what is now Chelsea Market | 52 |
| The first one was performed by Aleksei Leonov on 3/18/1965 | 58 |
| The first one went off in 1952 | 30 |
| The first one, bought by the Bulova Watch Co. for $9, ran on 7/1/1941 | 69 |
| The first ones last | 19 |
| The first or fifth letter of George | 35 |
| The First or Fourteenth, for example | 36 |
| The first or last one can be a doozy | 36 |
| The first part missing in the author's name ___ Vargas ___ | 62 |
| The first people to play crosswords | 35 |
| The first people to try crosswords | 34 |
| The first piece of information ever learned about you during your lifetime, probably | 84 |
| The first place | 15 |
| The first positive non-Fibonacci number | 39 |
| The first prophet of God, in Islam | 34 |
| The first requirement | 21 |
| The first second son | 20 |
| The first shepherd in the Bible | 31 |
| The first sign | 14 |
| The first six inches of a foot-long? | 36 |
| The first sixteen rows, perhaps | 31 |
| The first sound in Gary, but not Gerald | 39 |
| The first st. | 13 |
| The First State (abbr.) | 23 |
| The First State: Abbr. | 22 |
| The first string | 16 |
| The first T in TNT | 18 |
| The first T of AC/DC's "TNT"? | 43 |
| The first talkie, with "The" | 38 |
| The first to go on a strike, usually | 36 |
| The first to hear "Madam, I'm Adam" | 49 |
| The first to stab Caesar | 24 |
| The first to use acne medicine? | 31 |
| The first Tudor Henry | 21 |
| The first two periodic table entries | 36 |
| The first two Tudor kings | 25 |
| The first U.S. National Park | 28 |
| The first voice you hear in "The Wizard of Oz" | 56 |
| The first words of asterisked clues are kinds of them | 53 |
| The first words of the answers to asterisked clues are types of them | 68 |
| The first X of X-X-X | 20 |
| The first X of XXX | 18 |
| The first X-rated Bond film? | 28 |
| The first X? | 12 |
| The first: Abbr. | 16 |
| The fish in John McPhee's "The Founding Fish" | 59 |