| Optometric entrepreneur | 23 |
| Options for tying neckties | 26 |
| Options for reduced fare | 24 |
| Options for a cartoonist | 24 |
| Options during computer woes | 28 |
| Optional part of a suit | 23 |
| Optional Medicare section | 25 |
| Optional kick for Bahr | 22 |
| Option on some sporty cars | 26 |
| Option on some sports cars | 26 |
| Option most likely to succeed | 29 |
| Option in some new autos | 24 |
| Option in Polk's slogan | 27 |
| Option having a virgule | 23 |
| Option given by Howie Mandel | 28 |
| Option from Howie Mandel | 24 |
| Option for WWW surfers | 22 |
| Option for thickening soup | 26 |
| Option for the present | 22 |
| Option for the jet set | 22 |
| Option for the inn crowd? | 25 |
| Option for some surgeries | 25 |
| Option for some long trips | 26 |
| Option for soap or ice cream | 28 |
| Option for reduced fare | 23 |
| Option for one's return | 27 |
| Option for linking PCs | 22 |
| Option for DVD viewing | 22 |
| Option for dressing down | 24 |
| Option for demolishers | 22 |
| Option for a marinara base | 26 |
| Option for a long train trip | 28 |
| Option for a H.S. dropout | 25 |
| Option at the launderer's | 29 |
| Option at Sleepy's | 22 |
| Option after six months, say | 28 |
| Opting not to sunbathe? | 23 |
| Opting not to strike out? | 25 |
| Optimists' storage boxes | 28 |
| Optimists' activity | 23 |
| Optimists keep them alive | 25 |
| Optimistic, as an outlook | 25 |
| Optimistic theater audience? | 28 |
| Optimistic Miller play? | 23 |
| Optimistic expectations | 23 |
| Optimistic and then some | 24 |
| Optimistic about a stock | 24 |
| Optimist: "My ___" | 28 |
| Optimist's worldview | 24 |
| Optimist's view of time | 27 |
| Optimist's statement | 24 |
| Optimist's quality | 22 |
| Optimist's pronouncement | 28 |
| Optimist's hallmark | 23 |
| Optimist's feeling | 22 |
| Optimist's feature | 22 |
| Optimist's comment | 22 |
| Optimist's coloring | 23 |
| Optimist's attribute | 24 |
| Optimist's assertion | 24 |
| Optimism; cheerfulness | 22 |
| Optics device used by Newton | 28 |
| Opticians' products | 23 |
| Optician's selections | 25 |
| Optician's selection | 24 |
| Optician's products | 23 |
| Optician's product | 22 |
| Optician's display | 22 |
| Optician's creation | 23 |
| Optician's concern | 22 |
| Optical-instrument part | 23 |
| Optical products pioneer | 24 |
| Optical illusion illustrator | 28 |
| Optical illusion artist | 23 |
| Optic membrane: Comb. form | 26 |
| Optic activity during sleep | 27 |
| Opted for paper over plastic? | 29 |
| Opted for a new hair color | 26 |
| Opt out of the local union? | 27 |
| Opt not to get carry-out | 24 |
| Opt not to charge, perhaps | 26 |
| Opt for the gold watch? | 23 |
| Opt for a suit and tie | 22 |
| Oprah's TV network | 22 |
| Oprah's production studio | 29 |
| Oprah's Life Lift, e.g. | 27 |
| Oprah's doctor friend | 25 |
| Oprah's best-selling cook | 29 |
| Oprah's best friend | 23 |
| Oprah Winfrey's company | 27 |
| Oprah Winfrey forerunner Phil | 29 |
| Oprah has more than one | 23 |
| Oprah and Dr. Phil, e.g. | 24 |
| Oppressed by the heat? | 22 |
| Oppressed by people in power | 28 |
| Opposition to use of force | 26 |
| Opposition to A.C. flow | 23 |
| Opposition party member | 23 |
| Opposites of thinkers? | 22 |
| Opposites of opposites: Abbr. | 29 |